Redox‐Responsive Polymeric Nanoparticle for Nucleic Acid Delivery and Cancer Therapy: Progress, Opportunities, and Challenges DOI Open Access
Lei Xu, Yuan Cao,

XU Ya

et al.

Macromolecular Bioscience, Journal Year: 2023, Volume and Issue: 24(3)

Published: Aug. 13, 2023

Abstract Cancer development and progression of cancer are closely associated with the activation oncogenes loss tumor suppressor genes. Nucleic acid drugs (e.g., siRNA, mRNA, DNA) widely used for therapy due to their specific ability regulate expression any cancer‐associated However, nucleic negatively charged biomacromolecules that susceptible serum nucleases cannot cross cell membrane. Therefore, delivery tools required facilitate intracellular drugs. In past few decades, a variety nanoparticles (NPs) designed developed therapy. particular, polymeric NPs in response abnormal redox status cells have garnered much more attention as potential redox‐triggered nanostructure dissociation rapid release this review, important genes or signaling pathways regulating briefly introduced recent redox‐responsive is systemically summarized. The future NPs‐mediated challenges clinical translation also discussed.

Language: Английский

Multi-targeting inulin-based nanoparticles with cannabidiol for effective prevention of ulcerative colitis DOI Creative Commons
Xuan Zhang,

Xia Gao,

Xiangzhou Yi

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 25, P. 100965 - 100965

Published: Jan. 21, 2024

Language: Английский

Citations

6
ROS-scavenging microgels containing PTPσ receptor modulatory peptides synergistically alleviate inflammation and promote functional recovery post stroke DOI
Weiwei Zheng,

Kefei Zhao,

Liang Song

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 483, P. 149225 - 149225

Published: Feb. 2, 2024

Language: Английский

Citations

5
ROS-responsive charge reversal mesoporous silica nanoparticles as promising drug delivery system for neovascular retinal diseases DOI Creative Commons
Ahmed M. Elbedwehy, Jun Wu,

Hee-Kyung Na

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 373, P. 224 - 239

Published: July 17, 2024

Intravitreal injection of biodegradable implant drug carriers shows promise in reducing the frequency for neovascular retinal diseases. However, current intravitreal ocular devices have limitations adjusting release rates individual patients, thereby affecting treatment effectiveness. Accordingly, we developed mesoporous silica nanoparticles (MSNs) featuring a surface that reverse its charge response to reactive oxygen species (ROS) efficient delivery humanin peptide (HN) epithelial cells (ARPE-19). The MSN core, designed with pore size 2.8 nm, ensures high HN loading capacity 64.4% (w/w). We fine-tuned external MSNs by incorporating 20% Acetyl-L-arginine (Ar) create partial positive charge, while 80% conjugated thioketal (TK) methoxy polyethylene glycol (mPEG) act as ROS gatekeeper. Ex vivo experiments using bovine eyes revealed immobilization Ar-MSNs-TK-PEG (mean zeta potential: 2 mV) negatively charged vitreous. oxidative stress reversed -25 mV mPEG loss, facilitating diffusion impeded HN. In vitro studies showed ARPE-19 effectively internalize HN-loaded Ar-MSNs-TK, subsequently releasing peptide, which offered protection against stress-induced apoptosis, evidenced reduced TUNEL and caspase3 activation. inhibition neovascularization was further validated an oxygen-induced retinopathy (OIR) mouse model.

Language: Английский

Citations

5
Rosmarinic Acid Prevents Cisplatin-Induced Liver and Kidney Injury by Inhibiting Inflammatory Responses and Enhancing Total Antioxidant Capacity, Thereby Activating the Nrf2 Signaling Pathway DOI Creative Commons
Yifei Xiang, Min Ji, Liqin Wu

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(22), P. 7815 - 7815

Published: Nov. 13, 2022

Drug-induced liver and kidney damage is an emergent clinical issue that should be addressed. Rosmarinic acid (RA) has obvious anti-inflammatory antioxidant effects, so we evaluated the effects of RA pretreatment on serum tissues cisplatin (CP)-treated mice explored possible mechanisms. The results showed effectively downregulated serum, liver, levels ALT, AST, BUN, CRE inflammatory factors IL-1β, IL-6, TNF-α, simultaneously enhanced total capacity kidney. significantly reduced MPO, MDA, NO in tissue, inhibited mRNA expression TNF-α activated Nrf2 signaling pathway, upregulated downstream target genes. Our findings show could prevent alleviate acute injury caused by CP.

Language: Английский

Citations

22
Redox‐Responsive Polymeric Nanoparticle for Nucleic Acid Delivery and Cancer Therapy: Progress, Opportunities, and Challenges DOI Open Access
Lei Xu, Yuan Cao,

XU Ya

et al.

Macromolecular Bioscience, Journal Year: 2023, Volume and Issue: 24(3)

Published: Aug. 13, 2023

Abstract Cancer development and progression of cancer are closely associated with the activation oncogenes loss tumor suppressor genes. Nucleic acid drugs (e.g., siRNA, mRNA, DNA) widely used for therapy due to their specific ability regulate expression any cancer‐associated However, nucleic negatively charged biomacromolecules that susceptible serum nucleases cannot cross cell membrane. Therefore, delivery tools required facilitate intracellular drugs. In past few decades, a variety nanoparticles (NPs) designed developed therapy. particular, polymeric NPs in response abnormal redox status cells have garnered much more attention as potential redox‐triggered nanostructure dissociation rapid release this review, important genes or signaling pathways regulating briefly introduced recent redox‐responsive is systemically summarized. The future NPs‐mediated challenges clinical translation also discussed.

Language: Английский

Citations

12