Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(26)
Published: May 15, 2023
Abstract
The
application
of
medical
implants
has
greatly
improved
the
survival
rate
and
life
quality
patients.
Nevertheless,
in
recent
years,
there
are
increasing
cases
implant
dysfunction
or
failure
because
bacterial
infections.
Despite
significant
improvements
biomedicine,
still
serious
challenges
treatment
implant‐related
With
formation
biofilms
development
resistance,
these
limitations
lead
to
a
low
efficacy
conventional
antibiotics.
To
address
challenges,
it
is
urgent
exploit
innovative
strategies
for
Based
on
ideas,
environment‐responsive
therapeutic
platforms
with
high
selectivity,
drug
minor
dose‐limiting
toxicity
have
attracted
widespread
attention.
By
using
exogenous/endogenous
stimuli,
antibacterial
activity
therapeutics
can
be
activated
demand
exhibit
remarkable
effects.
Exogenous
stimuli
include
photo,
magnetism,
microwave,
ultrasound.
Endogenous
mainly
pathological
characteristics
infections
such
as
acidic
pH,
anomalous
temperature,
abnormal
enzymatic
activities.
In
this
review,
progress
spatiotemporally
controlled
release/activation
systematically
summarized.
Afterward,
opportunities
emerging
highlighted.
Finally,
hoped
that
review
will
offer
novel
ideas
techniques
combat
Journal of Materials Research and Technology,
Journal Year:
2023,
Volume and Issue:
27, P. 122 - 152
Published: Sept. 27, 2023
Titanium
(Ti)
and
its
alloys
are
commonly
used
implant
materials
in
orthopedics
due
to
their
good
corrosion
resistance,
mechanical
properties,
biocompatibility.
However,
the
inherent
biological
inertness
of
Ti
surface
leads
insufficient
osseointegration
antibacterial
ability,
which
may
result
failure.
Hydroxyapatite
(HA)
is
currently
most
widely
material
biomedical
field.
It
one
bioactive
coating
because
chemical
structural
similarity
natural
bone.
At
present,
many
techniques
deposit
HA
as
a
on
implants.
The
stability
important
factor
determining
success
implant.
In
addition,
biofunctional
ions
have
been
introduced
into
coatings
enhance
functional
performance.
This
article
aims
present
crystal
structure
characteristics
principle
doping
HA.
preparation
methods
for
deposition
discuss
advantages
limitations.
doped
improve
properties
bone
integration
also
reviewed.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
27, P. 288 - 302
Published: April 18, 2023
New
antimicrobial
strategies
are
urgently
needed
to
meet
the
challenges
posed
by
emergence
of
drug-resistant
bacteria
and
bacterial
biofilms.
This
work
reports
facile
synthesis
dynamic
covalent
nano-networks
(aDCNs)
composing
antibiotics
bearing
multiple
primary
amines,
polyphenols,
a
cross-linker
acylphenylboronic
acid.
Mechanistically,
iminoboronate
bond
drives
formation
aDCNs,
facilitates
their
stability,
renders
them
highly
responsive
stimuli,
such
as
low
pH
high
H2O2
levels.
Besides,
representative
A1B1C1
networks,
composed
polymyxin
B1(A1),
2-formylphenylboronic
acid
(B1),
quercetin
(C1),
inhibit
biofilm
Escherichia
coli,
eliminate
mature
biofilms,
alleviate
macrophage
inflammation,
minimize
side
effects
free
polymyxins.
Excellent
eradication
inflammation
amelioration
efficiency
networks
also
observed
in
peritoneal
infection
model.
The
synthesis,
excellent
performance,
biocompatibility
these
aDCNs
potentiate
much-needed
alternative
current
pipelines.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2378 - 2378
Published: Feb. 17, 2024
Statins,
widely
prescribed
for
lipid
disorders,
primarily
target
3-hydroxy-3-methylglutaryl-coenzyme
A
(HMG-CoA)
reductase
competitively
and
reversibly,
resulting
in
reduced
low-density
lipoprotein
cholesterol
(LDL-C).
This
mechanism
proves
effective
lowering
the
risk
of
lipid-related
diseases
such
as
ischemic
cerebrovascular
coronary
artery
diseases.
Beyond
their
established
use,
statins
are
under
scrutiny
potential
applications
treating
bone
The
focus
research
centers
mainly
on
simvastatin,
a
lipophilic
statin
demonstrating
efficacy
preventing
osteoporosis
aiding
fracture
defect
healing.
Notably,
these
effects
manifest
at
elevated
doses
(20
mg/kg/day)
statins,
posing
challenges
systematic
administration
due
to
limited
affinity.
Current
investigations
explore
intraosseous
delivery
facilitated
by
specialized
carriers.
paper
outlines
various
carrier
types,
characterizing
structures
underscoring
statins'
local
treatments
Journal of Functional Biomaterials,
Journal Year:
2023,
Volume and Issue:
15(1), P. 15 - 15
Published: Dec. 30, 2023
Biomimetic
dental
implants
are
regarded
as
one
of
the
recent
clinical
advancements
in
implant
surface
modification.
Coatings
with
varying
thicknesses
and
roughness
may
affect
surface’s
chemical
inertness,
cell
adhesion,
antibacterial
characteristics.
Different
coatings
mechanical
changes
have
been
studied
to
improve
osseointegration
decrease
peri-implantitis.
The
medication
increases
energy,
leading
enhanced
proliferation
growth
factors,
and,
consequently,
a
rise
process.
This
review
provides
comprehensive
update
on
numerous
biomimetic
used
characteristics
their
applications
two
main
categories:
coating
osseointegration,
including
hydroxyapatite
layer
nanocomposites,
factors
(BMPs,
PDGF,
FGF),
extracellular
matrix
(collagen,
elastin,
fibronectin,
chondroitin
sulfate,
hyaluronan,
other
proteoglycans),
for
anti-bacterial
performance,
covering
drug-coated
(antibiotic,
statin,
bisphosphonate),
antimicrobial
peptide
(GL13K
human
beta
defensins),
polysaccharide
(natural
chitosan
its
coupling
agents)
metal
elements
(silver,
zinc,
copper).
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
33, P. 223 - 241
Published: Nov. 17, 2023
Postoperative
anatomical
reconstruction
and
prevention
of
local
recurrence
after
tumor
resection
are
two
vital
clinical
challenges
in
osteosarcoma
treatment.
A
three-dimensional
(3D)-printed
porous
Ti6Al4V
scaffold
(3DTi)
is
an
ideal
material
for
reconstructing
critical
bone
defects
with
numerous
advantages
over
traditional
implants,
including
a
lower
elasticity
modulus,
stronger
bone-implant
interlock,
larger
drug-loading
space.
Simvastatin
multitarget
drug
anti-tumor
osteogenic
potential;
however,
its
efficiency
unsatisfactory
when
delivered
systematically.
Here,
simvastatin
was
loaded
into
3DTi
using
thermosensitive
poly
(lactic-co-glycolic)
acid
(PLGA)-polyethylene
glycol
(PEG)-PLGA
hydrogel
as
carrier
to
exert
anti-osteosarcoma
effects.
Newly
constructed
simvastatin/hydrogel-loaded
(Sim-3DTi)
comprehensively
appraised,
newfound
mechanism
explained.
Specifically,
defect
model
rabbit
condyles,
Sim-3DTi
exhibited
enhanced
osteogenesis,
in-growth,
osseointegration
compared
alone,
greater
morphogenetic
protein
2
expression.
In
our
nude
mice
model,
loading
reduced
volume
by
59%-77
%
without
organic
damage,
implying
good
activity
biosafety.
Furthermore,
induced
ferroptosis
upregulating
transferrin
nicotinamide
adenine
dinucleotide
phosphate
oxidase
levels
both
Future Pharmacology,
Journal Year:
2024,
Volume and Issue:
4(1), P. 3 - 16
Published: Jan. 5, 2024
Staphylococcus
aureus
is
a
causative
agent
of
nosocomial
infections
and
its
antibiotic-resistant
strains
give
cause
for
concern.
Solutions
are
being
explored
to
improve
treatment
these
infections,
including
repositioning
drugs
such
as
statins
using
nanoparticles
with
antimicrobial
properties.
This
study
evaluated
the
effects
simvastatin
(SIM)
biologically
synthesized
silver
(bio-AgNPs)
in
isolate
form
combination
assays
minimum
inhibitory
concentration
(MIC),
an
vitro
biofilm
model,
association
antimicrobials
against
clinical
S.
aureus.
Bio-AgNPs
showed
53.8
±
1.23
nm
mean
diameter
standard
deviation,
0.23
polydispersity
index,
−25.66
2.19
mV
potential
deviation.
Transmission
electron
microscopy
confirmed
formation
nanoparticles,
presence
Ag0
AgCl.
were
sensitive
bio-AgNPs
SIM,
showing
31.88–187.5
74.66–149.32
μM
concentrations,
respectively.
The
assay
2.0
fractional
indices
(i.e.,
indifferent
strains)
0.32
values
ATCC
29213
strain
(synergy).
Biofilm
inhibition
isolated
SIM
decreased
4×
⅛
MICs
no
synergism
association.
These
findings
evince
that
at
subinhibitory
concentrations
can
serve
agents
biofilm.
