Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
37, P. 549 - 562
Published: May 6, 2024
Zinc
(Zn)
alloys
have
demonstrated
significant
potential
in
healing
critical-sized
bone
defects.
However,
the
clinical
application
of
Zn
implants
is
still
hindered
by
challenges
including
excessive
release
zinc
ions
(Zn
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(5), P. 3283 - 3294
Published: May 10, 2024
Medical
implants
are
constantly
facing
the
risk
of
bacterial
infections,
especially
infections
caused
by
multidrug
resistant
bacteria.
To
mitigate
this
problem,
gold
nanoparticles
with
alkyl
bromide
moieties
(Au
NPs-Br)
on
surfaces
were
prepared.
Xenon
light
irradiation
triggered
plasmon
effect
Au
NPs-Br
to
induce
free
radical
graft
polymerization
2-(dimethylamino)ethyl
methacrylate
(DMAEMA),
leading
formation
poly(DMAEMA)
brush-grafted
NPs
NPs-
Journal of Functional Biomaterials,
Journal Year:
2025,
Volume and Issue:
16(2), P. 61 - 61
Published: Feb. 11, 2025
Osteogenic
differentiation
is
a
complex
process,
and
its
analysis
requires
several
biomarkers.
Allied
with
this,
there
are
no
standardized
bioassays
to
monitor
the
activity
of
simvastatin
in
osteogenesis
vitro.
Therefore,
identifying
most
efficient
sensitive
may
enhance
quality
vitro
studies,
bridging
gap
vivo
findings,
saving
time
resources,
benefiting
community.
This
systematic
review
aimed
determine
bioassay
for
simvastatin's
osteogenic
vitro,
terms
sensitivity.
In
studies
evaluating
undifferentiated
mesenchymal
cells
treated
were
considered
eligible.
References
selected
two-phase
process.
Electronic
databases
grey
literature
screened
up
September
2023.
The
Office
Health
Assessment
Translation
(OHAT)
tool
was
used
assess
risk
bias.
Certainty
cumulative
evidence
evaluated
using
Grading
Recommendations,
Assessment,
Development,
Evaluation
(GRADE)
criteria.
Data
analyzed
considering
extracellular
matrix
mineralization,
alkaline
phosphatase,
expression
potential
target
genes,
such
as
bone
morphogenetic
protein-2
(BMP-2),
collagen
type
I,
Runt-related
transcription
factor
2,
osterix,
osteocalcin,
osteopontin.
Fourteen
included.
A
"probably
low"
or
"definitely
bias
assigned
included
studies.
concentration
ranged
from
0.1
nM
10
µM.
Considering
minimum
4-fold
increase,
caused
robust
mineralization
four
(4.0-,
4.4-,
5.0-,
39.5-fold).
Moreover,
substantially
increased
BMP-2
three
(4-,
11-,
19-fold).
determining
(high
certainty
level).
These
findings
provide
approach
that
can
reliability
comparability
research
optimizing
resources
field
regeneration.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 28, 2025
Implant-associated
infections
pose
significant
challenges
due
to
bacterial
resistance
antibiotics.
Recent
research
highlights
the
potential
of
immobilizing
antimicrobial
peptides
(AMPs)
onto
implants
as
an
alternative
conventional
antibiotics
for
prevention
infection.
While
various
AMP
immobilization
methodologies
have
been
investigated,
they
lack
responsiveness
biological
cues.
This
study
proposes
enzyme-responsive
coating
orthopedic
devices
using
KR-12,
derived
from
Cathelicidin
LL-37,
coupled
with
Human
Elastin-Like
Polypeptide
(HELP)
a
biomimetic
and
stimuli-responsive
linker,
while
mimicking
extracellular
matrix
(ECM).
During
implantation,
these
customized
interfaces
encounter
innate
immune
response
triggering
elastase
release,
which
degrades
HELP
biopolymers,
enabling
controlled
release
KR-12.
After
coupling
KR-12
titanium
surfaces,
activity
against
four
pathogenic
strains
(Staphylococcus
aureus,
Staphylococcus
epidermidis,
Escherichia
coli,
Pseudomonas
aeruginosa)
was
assessed,
revealing
inhibition
ratio
adhesion
colonization
exceeding
92%
all
tested
strains,
compared
surfaces
functionalized
only.
It
is
thought
that
enhanced
improved
mobility
when
HELP.
Furthermore,
prepared
coatings
boosted
proliferation
human
osteoblasts,
confirming
cytocompatibility.
These
findings
suggest
smart
combine
functions
AMPs
HELP's
properties
use
in
variety
settings,
including
medical
devices.
