Journal of Neural Engineering,
Journal Year:
2024,
Volume and Issue:
21(4), P. 041001 - 041001
Published: July 23, 2024
Abstract
Peripheral
nerve
injury
(PNI)
represents
a
serious
clinical
and
public
health
problem
due
to
its
high
incurrence
poor
spontaneous
recovery.
Compared
autograft,
which
is
still
the
best
current
practice
for
long-gap
peripheral
defects
in
clinics,
use
of
polymer-based
biodegradable
guidance
conduits
(NGCs)
has
been
gaining
momentum
as
an
alternative
guide
repair
severe
PNI
without
need
secondary
surgery
donor
tissue.
However,
simple
hollow
cylindrical
tubes
can
barely
outperform
autograft
terms
regenerative
efficiency
especially
critical
sized
PNI.
With
rapid
development
tissue
engineering
technology
materials
science,
various
functionalized
NGCs
have
emerged
enhance
regeneration
over
past
decades.
From
aspect
scaffold
design
considerations,
with
specific
focus
on
polymers,
this
review
aims
summarize
recent
advances
by
addressing
onerous
demands
biomaterial
selections,
structural
designs,
manufacturing
techniques
that
contributes
biocompatibility,
degradation
rate,
mechanical
properties,
drug
encapsulation
release
efficiency,
immunomodulation,
angiogenesis,
overall
potential
NGCs.
In
addition,
several
commercially
available
along
their
regulation
pathways
applications
are
compared
discussed.
Lastly,
we
discuss
challenges
future
directions
attempting
provide
inspiration
ideal
completely
cure
defects.
MedComm – Biomaterials and Applications,
Journal Year:
2024,
Volume and Issue:
3(1)
Published: Feb. 3, 2024
Abstract
The
management
of
peripheral
nerve
injuries
is
an
important
concern
due
to
the
their
incidence
lesions
and
inappropriate
regeneration
that
follows
severe
injuries,
which
ultimately
reduces
lives
patients
with
this
condition.
Different
strategies
have
been
investigated
repair
improvement
motor
sensory
regeneration.
Although
autograft
remains
gold
standard
technique,
emerging
number
research
articles
concerning
conduit
use
reported
in
last
few
years.
Nerve
conduits
aim
overcome
disadvantages,
but
they
satisfy
some
requirements
be
suitable
for
repair.
A
universal
ideal
does
not
exist
since
properties
evaluated
case
by
case;
nevertheless,
because
high
biocompatibility
biodegradability,
natural‐based
biomaterials
great
potential
used
produce
guides.
many
characteristics
synthetic
biomaterials,
are
preferable
extraction
sources;
indeed,
these
obtained
from
different
renewable
sources
or
food
waste,
thus
reducing
environmental
impact
enhancing
sustainability
comparison
ones.
This
review
highlights
recent
progress
development
derivatives
injuries.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101503 - 101503
Published: Feb. 6, 2025
Peripheral
nerve
injuries
are
a
prevalent
global
issue
that
has
garnered
great
concern.
Although
autografts
remain
the
preferred
clinical
approach
to
repair,
their
efficacy
is
hampered
by
factors
like
donor
scarcity.
The
emergence
of
guidance
conduits
as
novel
tissue
engineering
tools
offers
promising
alternative
strategy.
This
review
aims
interpret
and
commercialization
from
both
laboratory
perspectives.
To
enhance
comprehension
situations,
this
article
provides
comprehensive
analysis
approved
United
States
Food
Drug
Administration.
It
proposes
initial
six
months
post-transplantation
critical
window
period
for
evaluating
efficacy.
Additionally,
study
conducts
systematic
discussion
on
research
progress
conduits,
focusing
biomaterials
add-on
strategies
pivotal
regeneration,
supported
literature
analysis.
conduit
materials
prospective
optimal
thoroughly
discussed.
strategies,
together
with
distinct
obstacles
potentials
deeply
analyzed.
Based
above
evaluations,
development
path
manufacturing
strategy
envisioned.
conclusion
promoting
summarized
follows:
1)
optimization
fundamental
means;
2)
phased
application
additional
emphasized
direction;
3)
additive
techniques
necessary
tools.
As
result,
findings
provide
academic
practitioners
valuable
insights
may
facilitate
future
endeavors
conduits.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 3, 2025
Abstract
After
injury,
the
imbalance
of
regeneration
microenvironment
caused
by
inflammation,
oxidative
stress,
insufficient
neurovascularization,
and
inadequate
energy
supply
affects
nerve
regeneration.
Drug‐delivery
conduits
play
a
role
in
repairing
regenerative
microenvironment.
However,
traditional
drugs
often
fail
to
cross
blood‐nerve
barrier
lack
multifunctionality,
limiting
effectiveness
conduit
therapy.
Therefore,
it
is
necessary
construct
multifunctional
that
regulate
timely
effectively.
Herein,
photo‐responsive
hydrogen
sulfide
(H
2
S)
composite
conduit,
artificially
controlled
H
S
release,
developed.
A
new
structure
zinc‐citric
acid
organic
metal
framework
(Zn‐CA
MOFs)
utilized
improve
its
drug
loading
rate,
achieving
joint
regulation
Zn
2+
.
In
addition,
RGD
modification
polyester
amide
(P(CL‐MMD‐MAC)‐RGD))
combined
with
aligned
used
performance
conduit.
Relevant
results
demonstrate
can
inflammatory
response
stress
promote
mitochondrial
function
recovery
angiogenesis.
Furthermore,
cell
adhesion
guide
directed
migration.
Overall,
this
study
provides
method
combining
gas
neurotransmitters
ions
microenvironment,
accelerate
regeneration,
restore
motor
function.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: March 28, 2025
The
management
of
bone
defects,
particularly
in
aging
populations,
remains
a
major
clinical
challenge.
immune
microenvironment
plays
an
important
role
the
repair
defects
and
favorable
environment
can
effectively
promote
defects.
However,
is
closely
associated
with
chronic
low-grade
systemic
inflammation,
which
adversely
affects
healing.
Persistent
inflammation
critically
regulates
through
all
stages.
This
review
explores
potential
3D-printed
bioceramic
scaffolds
defect
repair,
focusing
on
their
capacity
to
modulate
counteract
effects
aging.
not
only
provide
structural
support
for
regeneration
but
also
serve
as
effective
carriers
anti-osteoporosis
drugs,
offering
novel
therapeutic
strategy
treating
osteoporotic
By
regulating
improving
response,
may
significantly
enhance
context
age-related
degeneration.
approach
underscores
advanced
biomaterials
addressing
dual
challenges
dysregulation,
promising
avenues
development
treatments
elderly.
We
hope
concepts
discussed
this
could
offer
strategies
suggest
future
optimization
scaffolds.
