In Situ Sprayed Self‐Gelling Powder Self‐Assembled by a Pure Molecular Drug from Herbal Extract for Rapid Hemostasis and Neuroprotection in Traumatic Brain Injury

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Immediate hemostasis and effective treatment are foremost for acute intervention in traumatic brain injury (TBI), but the therapeutic tools professional methods often lacking at scene. Self‐gelling powders formed by self‐assembly of pure molecular drugs can quickly deliver hemostatic effects without complications from chemical modifications or additional carriers. However, no clinical have been reported as a self‐gelling powder this purpose. Here, is self‐assembled sodium aescinate (SA), drug already approved treating trauma. To generate SA (SA self‐gel‐P), heated cooled an alkaline solution to form hydrogel, then freeze‐dried ground. The obtained self‐gel‐P has good hydrophilicity. When sprayed onto bleeding site after TBI, it rapidly absorbed blood gel through intermolecular hydrogen bonding, facilitating situ sealing rapid hemostasis. Furthermore, hydrogel released over long period, which helped reduce neuronal death, improve integrity blood‐brain barrier, edema, alleviate neuroinflammation, ultimately promote recovery neurofunction significant toxic side effects. This may serve powerful auxiliary tool pre‐hospital TBI.

Language: Английский

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Application of Self‐Healing Hydrogels in the Treatment of Intervertebral Disc Degeneration

Journal of Biomedical Materials Research Part B Applied Biomaterials, Journal Year: 2025, Volume and Issue: 113(2)

Published: Jan. 22, 2025

ABSTRACT Intervertebral disc degeneration (IDD) is one of the leading causes chronic pain and disability, traditional treatment methods often struggle to restore its complex biomechanical properties. This article explores innovative application self‐healing hydrogels in IDD, offering new hope for repair due their exceptional self‐repair capabilities adaptability. As a key support structure human body, intervertebral discs are damaged by trauma or degenerative changes. Self‐healing not only mimic mechanical properties natural but also when damaged, thereby maintaining stable functionality. reviews mechanisms design strategies and, first time, outlines potential IDD. Furthermore, looks forward future developments field, including intelligent material design, multifunctional integration, encapsulation release bioactive molecules, combinations with tissue engineering stem cell therapy, perspectives IDD treatment.

Language: Английский

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All-Small-Molecule Supramolecular Hydrogel Combining Self-Delivery and ROS-Responsive Release for Inhibiting Tumor Growth and Postoperative Recurrence

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(9), P. 13494 - 13512

Published: Feb. 24, 2025

Supramolecular hydrogels show unprecedented advantages and have attracted widespread attention in biomedical sciences. However, it is challenging for bioactive star molecules, such as celastrol, to meet ideal formation conditions. Here, we report a dynamic covalent method construct dihydrol-type celastrol-phenylenediboronic acid-guanosine (DHcelPBG) supramolecular hydrogel. The DHcelPBG hydrogel can effectively accelerate 4T1 cell apoptosis by modulating the PI3K/Akt signaling pathway. Especially, serve self-delivery platform reactive oxygen species (ROS)-facilitated self-release. An excessive ROS-containing tumor microenvironment promote obtained kill more cells. Meanwhile, also exhibits distinguished degradability biocompatibility. Subsequently, orthotopic model results further demonstrate that remarkably inhibits growth does not damage healthy tissue. In postoperative recurrence model, prevents lung metastasis without causing adverse side effects, resulting an extended lifetime. integrates ROS-responsiveness, localized self-delivery, antitumor activity into one system breast cancer treatment with fewer showing great potential clinical transformation therapy.

Language: Английский

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Self-Assembled Reduction-Responsive Nanoparticles Constructed from Dual Topoisomerase I/Ii Inhibitor for Efficient Breast Cancer Treatment

Published: Jan. 1, 2025

Language: Английский

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Microenvironment-responsive nanoparticles functionalized titanium implants mediate redox balance and immunomodulation for enhanced osseointegration

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101628 - 101628

Published: March 2, 2025

Various pathological conditions (e.g., diabetes, osteoporosis) are accompanied by persistent oxidative stress, which compromises the immune microenvironment and poses substantial challenges for osseointegration. Reactive oxygen species (ROS) play a "double-edged sword" role in bone tissue. Therefore, developing responsive biomaterials to maintain redox balance dynamically is crucial enhanced Herein, microenvironment-responsive coordination nanoparticles (C-Ca-SalB NPs) composed of salvianolic acid B (SalB), catechol-conjugated chitosan (CS-C), Ca2+ constructed further covalently immobilized onto titanium implant surfaces. The resulting implants achieve on-demand antioxidant immunomodulatory effects manner, thus facilitating regeneration under both normal conditions. Under physiological conditions, functionalized display modest properties without affecting balance, while C-Ca-SalB NPs remain relatively stable. However, modified enable rapid decomposition acidic displaying robust ROS-scavenging, anti-inflammatory, osteoinductive capacities, ultimately remodeling into regenerative one. Overall, smart with controlled bioactive agent release this study present comprehensive solution enhancing bone-implant integration, particularly challenging context stress.

Language: Английский

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