Metabolic Acidity/H2O2 Dual‐Cascade‐Activatable Molecular Imaging Platform toward Metastatic Breast Tumor Malignancy DOI

Kun Dou,

Jiao Lu, Yanlong Xing

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Abstract Fluorescence imaging in the second near‐infrared window (NIR‐II) is crucial for accurate tumor diagnosis, offering superior resolution and penetration capabilities. Current NIR‐II probes are limited by either being “always on” or responding to one stimulus, leading low signal‐to‐noise ratios potential false positives. We introduced a dual‐lock‐controlled probe, HN‐PBA , activated both H 2 O acidic environment. This dual response ensures bright fluorescence at sites, higher tumor‐to‐normal tissue (T/NT) compared conventional only . strategy allows precise identification removal of primary metastatic tumors, achieving T/NT (24.3/6.4 orthotopic lung metastasis, respectively). Our probe also effectively detected foci as small as≤0.7 mm showed capability lesion localization clinical breast cancer specimens. dual‐stimuli‐responsive could aid future diagnostic design.

Language: Английский

Intelligent gold nanocluster for effective treatment of malignant tumor via tumor-specific photothermal–chemodynamic therapy with AIE guidance DOI Creative Commons

Feng Liu,

Tianfeng Yang,

Xiaowei Chang

et al.

National Science Review, Journal Year: 2024, Volume and Issue: 11(5)

Published: March 21, 2024

ABSTRACT Precise and efficient therapy of malignant tumors is always a challenge. Herein, gold nanoclusters co-modified by aggregation-induced-emission (AIE) molecules, copper ion chelator (acylthiourea) tumor-targeting agent (folic acid) were fabricated to perform AIE-guided tumor-specific synergistic with great spatio-temporal controllability for the targeted elimination metastasis inhibition tumors. During therapy, functional (AuNTF) would rapidly accumulate in tumor tissue due enhanced permeability retention effect as well folic acid-mediated targeting, which was followed endocytosis cells. After that, overexpressed ions cells trigger aggregation these intracellular AuNTF via chelation process that not only generated photothermal situ damaging primary tumor, but also led deficiency inhibit its metastasis. Moreover, reduced cuprous along chelation, further catalysed excess H2O2 produce cytotoxic reactive oxygen species, resulting additional chemodynamic antitumor efficiency. The activated AIE molecules present fluorescence, imaged therapeutic area real-time monitoring this allowed us near-infrared radiation at correct time point location achieve optimal therapy. Both vitro vivo results revealed strong elimination, effective high survival rate tumor-bearing mice after treatment using nanoclusters, indicating strategy could offer promising approach

Language: Английский

Citations

11
Ti3C2Tx MXene quantum dots coated hollow manganese dioxide nanoparticles for tumor combination therapy and magnetic resonance imaging DOI
Linwei Li,

Zihan Xing,

Tao Liao

et al.

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 39, P. 102171 - 102171

Published: June 24, 2024

Language: Английский

Citations

11
Dimethylcurcumin and Copper Sulfate-Loaded Silk Nanoparticles for Synergistic Therapy against Breast Cancer DOI
Bo Zhang, Yonghong Deng, Defeng Xu

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Dimethylcurcumin (ASC-J9) is an organic active pharmaceutical ingredient with anti-inflammatory, antioxidant, and antitumor effects. However, its application has been significantly hindered by poor solubility in aqueous solutions, a short vivo half-life, low bioavailability after oral administration, limited accumulation absorption target areas. Nano-drug delivery systems can serve as drug carriers to enhance delivery, addressing these challenges improved efficacy reduced adverse In this study, microfluidic swirl mixer used prepare silk fibroin composite nanoparticles containing ASC-J9 copper sulfate (CuS), the effects of different process parameters on (SNPs) were explored optimized. The synthesized ASC-J9-CuS@SNPs exhibited mean particle diameter 180 ± 10 nm PDI 0.20 0.03. Two-dimensional/three-dimensional (2D/3D) cell experiments showed that nanomaterials have excellent biocompatibility activity noticeable cancer specificity. effectively controlled tumor growth without causing damage blood cells vital organs. Both vitro demonstrated anticancer effect was enhanced photo thermotherapy. current study provides promising strategy for using nanocarriers breast therapy.

Language: Английский

Citations

0
Metabolic Acidity/H2O2 Dual‐Cascade‐Activatable Molecular Imaging Platform toward Metastatic Breast Tumor Malignancy DOI Open Access

Kun Dou,

Jiao Lu, Yanlong Xing

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Fluorescence imaging in the second near-infrared window (NIR-II) is crucial for accurate tumor diagnosis, offering superior resolution and penetration capabilities. Current NIR-II probes are limited by either being "always on" or responding to one stimulus, leading low signal-to-noise ratios potential false positives. We introduced a dual-lock-controlled probe, HN-PBA, activated both H

Language: Английский

Citations

2
H2O2‐Activatable Liposomal Nanobomb Capable of Generating Hypoxia‐Irrelevant Alkyl Radicals by Photo‐Triggered Cascade Reaction for High‐Performance Elimination of Biofilm Bacteria DOI
Ke Yang, Li Wang, Jinyi Chen

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 18, 2024

Abstract High H 2 O levels are widely present at the infection sites or in biofilm microenvironment. Herein, hemin with peroxidase‐like catalytic activity and its substrate, 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS), simultaneously introduced into a liposomal nanoparticle containing thermosensitive 2,2′‐azobis[2‐(2‐imidazolin‐2‐yl) propane] dihydrochloride (AIBI)‐loaded bovine serum albumin (BAG), rationally constructing an ‐activatable nanobomb (Lipo@BHA) for combating biofilm‐associated bacterial infections high performance. In presence of , can catalyze conversion ABTS oxidized form (ABTS· + ) strong near‐infrared (NIR) absorption, which produces photonic hyperpyrexia to cause decomposition AIBI oxygen‐independent alkyl radicals (·R) nitrogen (N microbubbles. The former not only directly damage cells but also significantly accelerates oxidization ABTS· augmenting photothermal‐triggered generation ·R. Interestingly, released N induce transient cavitation rupture lysosomal improve permeability, thereby enhancing antibiofilm effect Lipo@BHA. proposed Lipo@BHA exhibits satisfactory multi‐mode combination antibacterial properties. Through endogenous ‐activated cascade reaction, achieves remarkable hypoxia‐irrelevant ·R therapy wound low cytotoxicity good vivo biosafety. Therefore, this work presents versatile strategy biofilm‐specific therapeutic applications.

Language: Английский

Citations

1
Oncogenic miRNAs dependent photothermal-immunotherapy enhanced by on-demand manipulation of immunosuppressive microenvironment using engineered gold nanoparticles for effective treatment of primary and metastatic tumor DOI
Li Chen, Yu Hu, Wenyun Mu

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156958 - 156958

Published: Oct. 1, 2024

Language: Английский

Citations

1
Metabolic Acidity/H2O2 Dual‐Cascade‐Activatable Molecular Imaging Platform toward Metastatic Breast Tumor Malignancy DOI

Kun Dou,

Jiao Lu, Yanlong Xing

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Abstract Fluorescence imaging in the second near‐infrared window (NIR‐II) is crucial for accurate tumor diagnosis, offering superior resolution and penetration capabilities. Current NIR‐II probes are limited by either being “always on” or responding to one stimulus, leading low signal‐to‐noise ratios potential false positives. We introduced a dual‐lock‐controlled probe, HN‐PBA , activated both H 2 O acidic environment. This dual response ensures bright fluorescence at sites, higher tumor‐to‐normal tissue (T/NT) compared conventional only . strategy allows precise identification removal of primary metastatic tumors, achieving T/NT (24.3/6.4 orthotopic lung metastasis, respectively). Our probe also effectively detected foci as small as≤0.7 mm showed capability lesion localization clinical breast cancer specimens. dual‐stimuli‐responsive could aid future diagnostic design.

Language: Английский

Citations

0