Bacteria-tumor symbiosis destructible novel nanocatalysis drug delivery systems for effective tumor therapy DOI

Jing Zang,

Yin Fang, Ziyuan Liu

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: 20(3), P. 305 - 318

Published: Dec. 30, 2024

Colorectal cancer (CRC) is a significant threat to human health. The dynamic equilibrium between probiotics and pathogenic bacteria within the gut microbiota crucial in mitigating risk of CRC. An overgrowth harmful microorganisms gastrointestinal tract can result an excessive accumulation bacterial toxins carcinogenic metabolites, thereby disrupting delicate balance microbiota. This disruption may lead alterations microbial composition, impairment mucosal barrier function, potential promotion abnormal cell proliferation, ultimately contribute progression Recently, research has indicated that intestinal presence Fusobacterium nucleatum (Fn) significantly influences onset, progression, metastasis Consequently, interaction CRC cells Fn presents promising strategy against Nanomaterials have been extensively utilized therapy infection control, demonstrating substantial treating bacteria-associated tumors. review begins by elucidating mechanisms occurrence CRC, with particular emphasis on clarifying intricate relationship Subsequently, we highlight strategies utilize nanomaterials disrupt association Overall, this offers valuable insight guidance for leveraging therapy.

Language: Английский

L‐Arginine‐Modified Selenium Nanozymes Targeting M1 Macrophages for Oral Treatment of Ulcerative Colitis DOI Open Access
Shuaiwen Li, Zihui Chen, Minyu Wang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Ulcerative colitis (UC) involves persistent inflammation in the colon and rectum, with excessive reactive oxygen species (ROS) accumulation. This ROS buildup damages colonic epithelial cells disrupts intestinal flora, worsening disease progression. Current antioxidant therapies are limited due to their instability gut lack of targeting, hindering precise intervention at lesion site. study prepares an L-Arginine-modified selenium nanozyme (Se-CA) for targeted oral treatment UC. Se-CA specifically targets M1-type macrophages sites by binding cationic amino acid transporter protein 2 on surface macrophages. In vitro studies show that scavenges nitrogen (RNS) artificial gastric fluids, inhibits iron death cells. mice model ulcerative colitis, administration is effective through its anti-inflammatory properties, inhibition regulation flora. conclusion, this work provides new insights into

Language: Английский

Citations

0
Classification of Nanomaterial Drug Delivery Systems for Inflammatory Bowel Disease DOI Creative Commons
Haichen Wang, Feifei Zhou, Mengdan Shen

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1383 - 1399

Published: Feb. 1, 2025

Abstract: Inflammatory bowel disease (IBD), including Crohn's and ulcerative colitis, primarily arises from defects in the colonic barrier, imbalances of gut microbiota, immune response issues. These complex causes make it difficult to achieve a complete cure. Patients with IBD frequently experience recurrent abdominal pain bloody diarrhea, while severe cases may result intestinal obstruction, perforation, cancer. Lifelong maintenance therapy thus be needed manage these symptoms; however, traditional drugs, such as 5-aminosalicylic acid, glucocorticoids, immunosuppressants, biological agents, are often associated problems poor solubility, instability, ineffective targeting, well causing serious side effects non-target tissues. Nanomaterial drug delivery systems (NDDS) have recently shown great promise optimizing distribution, solubility through biocompatible coatings, enhancing bioavailability via PEGylation reducing effects. formulations can enhance drug's pharmacokinetics by modifying its properties, improve ability cross barriers, boost bioavailability. In addition, NDDS enable targeted delivery, increase local concentrations, efficacy, reduce effects, protecting active molecules recognition protease degradation. The clinical use for treating IBD, requires further research. This review summarizes classification concludes that, despite ongoing challenges, represent an effective treatment approach IBD. summary, therapeutic agents specific cells or tissues, thereby improving efficacy. effectively surmount facilitating efficient sites, which is crucial attaining optimal outcomes. contributes deeper understanding how physicochemical properties influence pharmacological behavior vivo expedite their translation. Keywords: inflammatory disease, nanomaterials, nano-delivery systems, nanomedicine applications

Language: Английский

Citations

0
A Dual-Polysaccharide (Carboxylated Chitosan-Carboxymethyl Cellulose Sodium) Gastrointestinal Dynamic Response in Situ Hydrogel for Optimized Oral Targeted Ibd Therapy DOI
Yuchen Zhang,

Kailai Liu,

Yunhe Zheng

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
CaGA nanozymes inhibit oxidative stress and protect mitochondrial function in ulcerative colitis therapy DOI
Liting Lin, Qingrong Li, Yang Yan

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Multifunctional Double-Loaded Oral Nanoplatform for Computed Tomography Imaging-Guided and Integrated Treatment of Inflammatory Bowel Disease DOI

Yaoting He,

Ziyang Jin,

Yifan Wang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Excessive reactive oxygen species, disruption of the epithelial barrier, immune dysregulation, and gut microbiota imbalance are key factors driving onset inflammatory bowel disease (IBD) complicating its treatment. Prompt diagnosis diseases precise delivery therapeutic agents to inflamed intestinal sites offer promising targeted strategies for effectively treating IBD. Here, a barium sulfate-based nanoplatform (BaSO4@PDA@CeO2/DSP, BPCD) synergistic nanozymes drugs was developed. With enhanced colonic retention after oral drug delivery, this enables effective targeting CT imaging guidance address multiple contributing A comprehensive effect achieved through action cerium oxide with optimized Ce3+/Ce4+ ratio sustained release dexamethasone sodium phosphate. Benefiting from superior gastrointestinal stability, is highly in IBD by alleviating oxidative stress, modulating macrophage polarization balance, flora composition, repairing barrier. BPCD inhibits development mechanisms has biocompatibility, emerging as practical alternative traditional therapies.

Language: Английский

Citations

0
Longitudinal Multi-Omics Analysis of the Gut-Liver Axis: Unraveling the Molecular Mechanisms of Metabolic Homeostasis Regulation by Pd@Pt Nanozymes DOI Creative Commons
Yanan Wang,

Nan Cheng,

Qí Zhāng

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101685 - 101685

Published: March 19, 2025

Language: Английский

Citations

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A Cerium Nanocluster for Effective Alleviation of Inflammatory Bowel Disease by Scavenging RONS and Regulating Gut Microbiome DOI Creative Commons
Dan Yang, Rong Wang, Lei Zhao

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101705 - 101705

Published: March 1, 2025

Language: Английский

Citations

0
“Three-birds, one-stone” biomimetic nanozyme system based on oxygen vacancy structure-regulated cascade reaction for inflammatory bowel disease DOI
Tianliang Li, Zhaoming Wang, Zhijie Wang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162172 - 162172

Published: April 1, 2025

Language: Английский

Citations

0
Regulation of signaling pathways by metal and metal-doped nanozymes in inflammatory bowel disease: A therapeutic perspective DOI
Mydhili Govindarasu,

Jomon George Joy,

Garima Sharma

et al.

Nano Today, Journal Year: 2025, Volume and Issue: 63, P. 102747 - 102747

Published: April 7, 2025

Language: Английский

Citations

0
A Nanosystem Alleviates Severe Acute Pancreatitis via Reactive Oxygen Species Scavenging and Enhancing Mitochondrial Autophagy DOI Creative Commons
Liying Wang,

Zerui Gao,

Mengxiang Tian

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Severe acute pancreatitis (SAP) is a life-threatening condition characterized by excessive reactive oxygen species (ROS) production and impaired mitochondrial function, resulting from disrupted autophagic flux. Current clinical treatment for SAP fails to address the comprehensively, with targeting only single pathogenesis. Herein, we report an innovative acid-responsive biomimetic nanozyme. This system features hollow Prussian blue (PB) core, serving as ROS scavenger encapsulated within porous ZIF-8 shell, enabling efficient delivery of celastrol that activates Encased in macrophage membrane, this selectively targets inflamed pancreatic tissues readily internalized acinar cells. dual-scavenging mechanism effectively attenuates inflammatory cytokine levels restores homeostasis three distinct mouse models. Overall, study presents promising synergistic strategy dual scavenging damaged mitochondria ROS, offering novel therapeutic approach SAP.

Language: Английский

Citations

0