Bioinspired conductive oriented nanofiber felt with efficient ROS clearance and anti-inflammation for inducing M2 macrophage polarization and accelerating spinal cord injury repair DOI Creative Commons
Qingxia Zhang, Jiahe Zheng, Linlong Li

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 46, P. 173 - 194

Published: Dec. 13, 2024

Language: Английский

3D bioprinted dynamic bioactive living construct enhances mechanotransduction-assisted rapid neural network self-organization for spinal cord injury repair DOI Creative Commons
Jia Yang,

Kunkoo Kim,

Yaosai Liu

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 46, P. 531 - 554

Published: Jan. 8, 2025

Language: Английский

Citations

1

Silk Fibroin-Based Triboelectric Nanogenerators for Energy Harvesting and Biomedical Applications DOI

Ni Gan,

Wei Meng, Qian Zhou

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(8), P. 8407 - 8423

Published: April 4, 2024

Triboelectric nanogenerators (TENGs) developed from eco-friendly natural materials rather than traditional electronic are more favorable for biocompatible applications and use in sustainable life-cycle analysis. Silk fibroin (SF) has emerged as an abundant biomaterial that shows great potential the preparation of TENGs. Silk-based triboelectric (SF-TENGs) have green energy harvesting properties, environmentally friendly, biocompatible, not fully present conventional TENGs, important next generation self-powered devices. In this review, latest progress SF-TENGs, including their applied materials, structural manufacturing processes, application scenarios, is discussed. These SF-TENGs show emerging well smart living medical assistance. addition, value been further explored, possibility main challenges expanding applying to field microneedles (MNs)

Language: Английский

Citations

7

Hydrogel-based therapeutic strategies for spinal cord injury repair: Recent advances and future prospects DOI
Na Li,

Jintao He

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134591 - 134591

Published: Aug. 8, 2024

Language: Английский

Citations

7

Innovative Strategies in 3D Bioprinting for Spinal Cord Injury Repair DOI Open Access

Daniel Youngsuk Kim,

Yanting Liu,

Gyubin Kim

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9592 - 9592

Published: Sept. 4, 2024

Spinal cord injury (SCI) is a catastrophic condition that disrupts neurons within the spinal cord, leading to severe motor and sensory deficits. While current treatments can alleviate pain, they do not promote neural regeneration or functional recovery. Three-dimensional (3D) bioprinting offers promising solutions for SCI repair by enabling creation of complex tissue constructs. This review provides comprehensive overview 3D techniques, bioinks, stem cell applications in repair. Additionally, it highlights recent advancements bioprinted scaffolds, including integration conductive materials, incorporation bioactive molecules like neurotrophic factors, drugs, exosomes, design innovative structures such as multi-channel axial scaffolds. These strategies offer approach optimizing microenvironment, advancing understanding state repair, offering insights into future directions field regenerative medicine.

Language: Английский

Citations

4

Advances of naturally derived biomedical polymers in tissue engineering DOI Creative Commons
Tao Hu, Jie Fang,

Yang Shen

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 20, 2024

The extensive utilization of natural polymers in tissue engineering is attributed to their excellent biocompatibility, degradability, and resemblance the extracellular matrix. These have a wide range applications such as delivering therapeutic medicine, detecting diseases, sensing biological substances, promoting regeneration, treating diseases. This brief review current developments properties uses widely used biomedical derived from nature. Additionally, it explores correlation between characteristics functions these materials different highlights prospective direction for advancement polymer engineering.

Language: Английский

Citations

4

Anisotropic structure of nanofiber hydrogel accelerates diabetic wound healing via triadic synergy of immune-angiogenic-neurogenic microenvironments DOI

Kunkoo Kim,

Jiakuan Yang, Chengli Li

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 64 - 82

Published: Jan. 11, 2025

Language: Английский

Citations

0

Adhesive and Conductive Hydrogels for the Treatment of Myocardial Infarction DOI Open Access

Jialiang Zhao,

Ying Chen, Yuanyuan Qin

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Myocardial infarction (MI) is a leading cause of mortality among cardiovascular diseases. Following MI, the damaged myocardium progressively being replaced by fibrous scar tissue, which exhibits poor electrical conductivity, ultimately resulting in arrhythmias and adverse cardiac remodeling. Due to their extracellular matrix‐like structure excellent biocompatibility, hydrogels are emerging as focal point tissue engineering. However, traditional lack necessary conductivity restore signal transmission infarcted regions. Imparting while also enhancing adhesive properties enables them adhere closely myocardial establish stable connections, facilitate synchronized contraction repair within area. This paper reviews strategies for constructing conductive hydrogels, focusing on application MI repair. Furthermore, challenges future directions developing discussed.

Language: Английский

Citations

0

Composite barrier membrane for bone regeneration: advancing biomaterial strategies in defect repair DOI Creative Commons

Qingbin Han,

Delu Zhao, Xiaohong Wang

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(2), P. 1290 - 1299

Published: Jan. 1, 2025

Preparation of GelMA/HAp/HAM barrier membranes. Bone defect regeneration rat calvaria in vivo .

Language: Английский

Citations

0

Multifunctional hydrogel microspheres regulate the balance of osteoblastic-osteoclastogenesis to treat osteoporotic bone defects by the NFATc1/RANKL/MAPK signaling DOI Creative Commons
Dongping Wang, Jiamin Yang, Chang Liu

et al.

Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112195 - 112195

Published: Feb. 1, 2025

Language: Английский

Citations

0

Spinal Cord Injury Repair Based on Drug and Cell Delivery: from Remodeling Microenvironment to Relay Connection Formation DOI Creative Commons

Wanrong Ma,

Xing Li

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101556 - 101556

Published: Feb. 4, 2025

Spinal cord injury (SCI) presents a formidable challenge in clinical settings, resulting sensory and motor function loss imposing significant personal societal burdens. However, owning to the adverse microenvironment limited regenerative capacity, achieving complete functional recovery after SCI remains elusive. Additionally, traditional interventions including surgery medication have series of limitations that restrict effectiveness treatment. Recently, tissue engineering (TE) has emerged as promising approach for promoting neural regeneration SCI, which can effectively delivery drugs into site cells improve survival differential. Here, we outline main pathophysiology events post injury, further discuss materials common assembly strategies used scaffolds treatment, expound on latest advancements treatment methods based drug cell detail, propose future directions repair with TE highlight potential applications.

Language: Английский

Citations

0