Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 14, 2024

Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against

Language: Английский

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Biomimetic reactive oxygen/nitrogen nanoscavengers inhibit “ferroptosis storm” and modulate immune targeting for acute kidney injury

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 59 - 76

Published: Jan. 8, 2025

Language: Английский

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Ferrostatin-1 inhibits osteoclast differentiation and prevents osteoporosis by suppressing lipid peroxidation

Journal of Orthopaedic Surgery and Research, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 30, 2025

Language: Английский

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Targeting ferroptosis: opportunities and challenges of mesenchymal stem cell therapy for type 1 diabetes mellitus

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 4, 2025

Abstract Type 1 diabetes mellitus (T1DM) is characterized by progressive β-cell death, leading to loss and insufficient insulin secretion. Mesenchymal stem cells (MSCs) transplantation currently one of the most promising methods for replacement therapy. However, recent studies have shown that ferroptosis not only key mechanisms but also reasons extensive cell death within a short period time after MSCs transplantation. Ferroptosis new type regulated (RCD) iron-dependent accumulation lipid peroxides. Due weak antioxidant capacity β-cells, they are susceptible cytotoxic stimuli such as oxidative stress (OS), therefore ferroptosis. Transplanted extremely perturbations in their microenvironment, especially OS, which can weaken induce through In pathophysiological process T1DM, large amount reactive oxygen species (ROS) produced, causing OS. Therefore, targeting may be way protect β-cells improve therapeutic effect This review reviews research related MSCs, summarizes developed strategies help inhibit study aims understand mechanism transplantation, emphasize importance protecting improving survival function transplanted provide direction therapy T1DM future.

Language: Английский

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Advances in Ferroptosis Research: A Comprehensive Review of Mechanism Exploration, Drug Development, and Disease Treatment

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 334 - 334

Published: Feb. 26, 2025

In recent years, ferroptosis, as an emerging modality of programmed cell death, has captured significant attention within the scientific community. This comprehensive review meticulously canvasses pertinent literature past few spanning multiple facets. It delves into intricate mechanisms underpinning tracks evolution its inducers and inhibitors, dissects roles in a diverse array diseases, well resultant therapeutic implications. A profound exploration is conducted functional ferroptosis-related molecules, intracellular pathways, metabolic cascades, signaling transduction routes. Novel ferroptosis inhibitors are introduced detail, covering their design blueprints, synthetic methodologies, bioactivity profiles. Moreover, exhaustive account provided regarding involvement malignancies, neurodegenerative disorders, cardiovascular ailments, other pathologies. By highlighting pivotal status potential regimens various this aspires to furnish thorough reference framework for future investigations clinical translations domain.

Language: Английский

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Ferrostatin-1 inhibits tracheal basal cell ferroptosis to facilitate the rapid epithelization of 3D-printed tissue-engineered tracheas

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 24, 2025

Tracheal replacement is a promising approach for treating tracheal defects that are caused by conditions such as stenosis, trauma, or tumors. However, slow postoperative epithelial regeneration often leads to complications, infection and granulation tissue formation. Ferroptosis, which an iron-dependent form of regulated cell death, limits the proliferation basal cells (TBCs), essential epithelialization tissue-engineered tracheas (TETs). This study explored potential ferrostatin-1 (FER-1), ferroptosis inhibitor, increase TBC accelerate 3D-printed TETs. TBCs were isolated from rabbit bronchial mucosal tissues cultured in vitro. Ferroptosis was induced at passage 2, shown increased reactive oxygen species (ROS) levels, Fe2⁺ accumulation, decreased ATP contents, mitochondrial damage. treated with FER-1 (1 μM) 48 h inhibit ferroptosis. The effects on ROS morphology measured. For vivo experiments, FER-1-treated seeded onto polycaprolactone (PCL) scaffolds, implanted into rabbits injury. Epithelial formation evaluated 6 months after surgery. treatment significantly reduced marker levels vitro; is, ameliorated structures, levels. viability inhibition. In vivo, group received scaffolds exhibited accelerated TET compared control groups. These results suggest inhibiting improves function, leading more efficient repair. Ferrostatin-1 effectively inhibits cells, promoting their proliferation. faster tracheas, offering strategy improving reconstruction outcomes reducing complications Future studies needed further investigate molecular mechanisms underlying its clinical applications.

Language: Английский

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Natural products protect against spinal cord injury by inhibiting ferroptosis: a literature review

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 3, 2025

Spinal cord injury (SCI) is a severe traumatic condition that frequently results in various neurological disabilities, including significant sensory, motor, and autonomic dysfunctions. Ferroptosis, recently identified non-apoptotic form of cell death, characterized by the accumulation reactive oxygen species (ROS), intracellular iron overload, lipid peroxidation, ultimately culminating death. Recent studies have demonstrated ferroptosis plays critical role pathophysiology SCI, contributing significantly to neural demise. Three key cellular enzymatic antioxidants such as glutathione peroxidase 4 (GPX4), suppressor protein 1 (FSP1), dihydroorotate dehydrogenase (DHODH), been elucidated crucial components defense against ferroptosis. Natural products, which are bioactive compounds mostly derived from plants, garnered considerable attention for their potential therapeutic effects. Numerous reported several natural products can effectively mitigate death alleviate SCI symptoms. This review summarizes fifteen containing (-)-Epigallocatechin-3-gallate (EGCG), Proanthocyanidin, Carnosic acid, Astragaloside IV, Trehalose, 8-gingerol, Quercetin, Resveratrol, Albiflorin, Alpha-tocopherol, Celastrol, Hispolon, Dendrobium Nobile Polysaccharide, Silibinin, Tetramethylpyrazine shown promise treating inhibiting Additionally, this provides an overview mechanisms involved these proposes perspectives guide future research directions.

Language: Английский

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Multifunctional hydrogels loaded with tellurium nanozyme for spinal cord injury repair

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101339 - 101339

Published: Nov. 12, 2024

Language: Английский

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Current multi-scale biomaterials for tissue regeneration following spinal cord injury

Neurochemistry International, Journal Year: 2024, Volume and Issue: 178, P. 105801 - 105801

Published: July 5, 2024

Language: Английский

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Physicochemical Property Effects on Immune Modulating Polymeric Nanoparticles: Potential Applications in Spinal Cord Injury

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13357 - 13374

Published: Dec. 1, 2024

Nanoparticles (NPs) offer promising potential as therapeutic agents for inflammation-related diseases, owing to their capabilities in drug delivery and immune modulation. In preclinical studies focusing on spinal cord injury (SCI), polymeric NPs have demonstrated the ability reprogram innate cells. This reprogramming results redirecting cells away from site, downregulating pro-inflammatory signaling, promoting a regenerative environment post-injury. However, fully understand mechanisms driving these effects maximize efficacy, it is crucial assess NP interactions with review examines how physicochemical properties of influence modulation system. To achieve this, delves into roles played by SCI investigates various cellular subsequent Key such size, surface charge, molecular weight, shape/morphology, functionalization, polymer composition are thoroughly examined. Furthermore, establishes connections between immunomodulatory functions NPs. Ultimately, this suggests that leveraging could serve strategy treating potentially other inflammatory diseases.

Language: Английский

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