3D tumor cultures for drug resistance and screening development in clinical applications

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 21, 2025

Tumor drug resistance presents a growing challenge in medical practice, particularly during anti-cancer therapies, where the emergence of drug-resistant cancer cells significantly complicates clinical treatment. In recent years, three-dimensional (3D) tumor culture technology, which more effectively simulates vivo physiological environment, has gained increasing attention research and applications. By mimicking cellular microenvironment, 3D technology not only recapitulates cell-cell interactions but also faithfully reproduces biological effects therapeutic agents. Consequently, is emerging as crucial tool biomedical research. We summarize benefits models organoid explore their application realm resistance, screening, personalized therapy, discuss potential prospects challenges transformation, with aim providing insights for optimizing treatment strategies advancing precision therapy.

Language: Английский

A Comprehensive Review on Stimuli-Responsive Nanomaterials: Advancements in Wound Healing and Tissue Regeneration

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Language: Английский

Chitosan microcarriers loaded with functional drug for stimulating osteogenesis and angiogenesis in vitro

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137598 - 137598

Published: Nov. 17, 2024

Language: Английский