Release of antibiotics from the materials for postosteomyelitic bone defect filling DOI Creative Commons
М. В. Стогов, А. Л. Шастов, Е. А. Киреева

et al.

Genij Ortopedii, Journal Year: 2024, Volume and Issue: 30(6), P. 873 - 880

Published: Dec. 18, 2024

Introduction The search for materials bone defect filling that would provide a release of antibiotics in therapeutic levels over long period is pressing issue the treatment patients with osteomyelitis. purpose work was to compare kinetics antibiotic from based on polyurethane polymers post-osteomyelitic defects. Materials and methods A comparative vitro analysis kinetic cefotaxime, vancomycin, meropenem two performed: one (RK series) other polymethyl methacrylate (PMMA series). In each series, were added original three proportions: polymer/ — 10:1 (group 1); 10:0.5 2), 10:0.25 3). samples incubated 10 ml saline at 37 °C. incubation solution changed daily during first week, then once week. Six group. Results It revealed volume eluted cefotaxime PMMA series higher than RK all concentrations. turn, vancomycin meropenem, it observed only group 1 samples. For groups 0.5 0.25, larger released noted series. found an effective (therapeutic) concentration more prolonged. there prolonged concentrations but smaller Discussion Each material showed its own elution profile them may have indications. RK-based has advantages terms duration doses. Conclusion studied longer PMMA-based material.

Language: Английский

Directional Freeze‐Casting Cryogel Loaded with Quaternized Chitosan Modified Gallium Metal–Organic Frameworks to Capture and Eradicate the Resistant Bacteria for Guided Regeneration in Infected Bone Defects DOI Open Access
Yihao Liu, Kai Yuan, Yixuan Lin

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Abstract Antimicrobial resistance and impaired bone regeneration are the great challenges in treating infected defects. Its recurrent resistant nature, high incidence rate, long‐term hospitalization, medical costs have driven efforts of scientific community to develop new therapies improve situation. Considering complex microenvironment persistent mechanisms mediated by bacteria, it is crucial an implant with enhanced osseointegration sustained effective infection clearance effects. Here, a positively charged quaternized chitosan (QCS) coated gallium‐based metal–organic framework (GaMOF) designed, capture antibiotic‐resistant bacteria (Methicillin‐resistant Staphylococcus aureus , MRSA) as “captor”, rejuvenate Methicillin (Me) via disturbing tricarboxylic acid (TCA) cycle. Then, radially oriented porous cryogel loaded Me QCSGaMOF fabricated directional freeze‐casting method. The structure has effect guiding ingrowth osteogenic cells. In vitro vivo experiments prove advantages as‐prepared Me/QCSGa‐MOF@Cryogel combating

Language: Английский

Citations

1
Baiting bacteria with amino acidic and peptidic corona coated defect-engineered antimicrobial nanoclusters for optimized wound healing DOI Creative Commons
Maonan Wang, Houjuan Zhu,

Yuling Xue

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 42, P. 628 - 643

Published: Sept. 24, 2024

Language: Английский

Citations

4
Artificial Bone Materials for Infected Bone Defects: Advances in Antimicrobial Functions DOI

Di Ying,

Tianshou Zhang, Manlin Qi

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Infected bone defects, caused by bacterial contamination following disease or injury, result in the partial loss destruction of tissue. Traditional transplantation and other clinical approaches often fail to address therapeutic complexities these conditions effectively. In recent years, advanced biomaterials have attracted significant attention for their potential enhance treatment outcomes. This review explores pathogenic mechanisms underlying infected including biofilm formation internalization into cells, which allow bacteria evade host immune system. To control infection facilitate repair, we focus on antibacterial materials regeneration. A detailed introduction is given intrinsically (e.g., metal alloys, oxide materials, carbon-based hydroxyapatite, chitosan, Sericin). The functionality repair can be enhanced through strategies such as incorporation antimicrobial ions, surface modification, combined use multiple treat defects. Key innovations discussed include that release agents, functional contact biomaterials, bioresponsive collectively efficacy. Research translation has also facilitated practical application prevention healing. conclusion, advancements provide promising pathways developing more biocompatible, effective, personalized therapies reconstruct

Language: Английский

Citations

0
Electro‐ and Magneto‐Active Biomaterials for Diabetic Tissue Repair: Advantages and Applications DOI Open Access
Kai Mao, Muxin Yue, Huiping Ma

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Abstract The diabetic tissue repair process is frequently hindered by persistent inflammation, infection risks, and a compromised microenvironment, which lead to delayed wound healing significantly impact the quality of life for patients. Electromagnetic biomaterials offer promising solution enabling intelligent detection wounds through electric magnetic effects, while simultaneously improving pathological microenvironment reducing oxidative stress, modulating immune responses, exhibiting antibacterial action. Additionally, these materials inherently promote regeneration regulating cellular behavior facilitating vascular neural repair. Compared traditional biomaterials, electromagnetic provide advantages such as noninvasiveness, deep penetration, responsiveness, multi‐stimuli synergy, demonstrating significant potential overcome challenges This review comprehensively examines superiority in repair, elucidates underlying biological mechanisms, discusses specific design strategies applications tailored characteristics wounds, with focus on skin bone defect By addressing current limitations pursuing multi‐faceted strategies, hold improve clinical outcomes enhance

Language: Английский

Citations

0
A self-assembly strategy for fabricating tough and magneto-responsive scaffolds to promote osteogenesis with enhanced vascularization DOI
Yi Zhou, Huan Liang, Chao Liu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163129 - 163129

Published: April 1, 2025

Language: Английский

Citations

0
Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1+ Macrophages for Infectious Bone Defect Regeneration DOI
Hao Wu, Changcheng Chen, Jiangfeng Li

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(52), P. 35575 - 35594

Published: Dec. 18, 2024

Infectious bone defects pose significant clinical challenges due to persistent infection and impaired healing. Icam1+ macrophages were identified as crucial previously unrecognized regulators in the repair of defects, where oxidative phosphorylation within this macrophage subset represents a barrier effective regeneration. To address challenge, dual-responsive iron-doped barium titanate (BFTO) nanoparticles synthesized with magnetic ultrasonic properties. These further loaded anti-inflammatory agent curcumin coated engineered mesenchymal stem cell membranes (EMM) modified γ3 peptide, creating BFTO-Cur@EMM specifically designed target macrophages. shown disrupt bacterial biofilms under alternating fields (AMF) activate osteogenic immune responses via low-intensity pulsed ultrasound (LIPUS). Transcriptomic sequencing validation experiments demonstrated that approach activates (OXPHOS) by stimulating JAK2-STAT3 pathway inhibiting MAPK-JNK pathway, thereby promoting polarization toward pro-reparative phenotype enhancing secretion pro-angiogenic cytokines. subsequently integrated into quaternized chitosan (QCS) tricalcium phosphate (TCP) create bioink for three-dimensional (3D) printing anti-infection QT/BFTO-Cur@EMM scaffolds. In vivo studies indicated these scaffolds significantly improved healing infectious without causing thermal damage surrounding tissues. This work highlights potential material targeting an strategy simultaneously controlling

Language: Английский

Citations

3
Efficacy of pH‐Responsive Surface Functionalized Titanium Screws in Treating Implant‐associated S. aureus Osteomyelitis with Biofilms Formation DOI Creative Commons
Hang Zhou, Youliang Ren,

Kaidian Zou

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Abstract Implant‐associated Staphylococcus aureus (S. aureus) osteomyelitis (IASO) leads to high orthopedic implant failure rates due the formation of Staphylococcal abscess community within bone marrow and bacterial colonization in osteocyte lacuno‐canalicular network (OLCN). To address this, antimicrobial peptides (HHC36)‐loaded titania nanotubes (NTs) are developed on titanium screws (Ti‐NTs‐P‐A), which integrate pH‐responsive polymethacrylic acid control HHC36 release for eradicating bacteria IASO. Colony‐forming unit assay confirmed that Ti‐NTs‐P‐A maintained sustainable antibacterial effectiveness, killing over 65% S. even after multiple solution replacements. Notably, exhibit significant behavior bactericidal activity, consistent with phenotype peptides‐killed from scanning electron microscopy. Transcriptome sequencing results reveal interfered ribosome disrupted arginine biosynthesis, is crucial survival acidic environments. In non‐infected model, bone‐implant contact ratio screw 2.3 times clinically used screw. an IASO effectively eradicated OLCN, achieving 80% infection rate desirable osteointegration. Collectively, properties great potential osseointegration

Language: Английский

Citations

1
Release of antibiotics from the materials for postosteomyelitic bone defect filling DOI Creative Commons
М. В. Стогов, А. Л. Шастов, Е. А. Киреева

et al.

Genij Ortopedii, Journal Year: 2024, Volume and Issue: 30(6), P. 873 - 880

Published: Dec. 18, 2024

Introduction The search for materials bone defect filling that would provide a release of antibiotics in therapeutic levels over long period is pressing issue the treatment patients with osteomyelitis. purpose work was to compare kinetics antibiotic from based on polyurethane polymers post-osteomyelitic defects. Materials and methods A comparative vitro analysis kinetic cefotaxime, vancomycin, meropenem two performed: one (RK series) other polymethyl methacrylate (PMMA series). In each series, were added original three proportions: polymer/ — 10:1 (group 1); 10:0.5 2), 10:0.25 3). samples incubated 10 ml saline at 37 °C. incubation solution changed daily during first week, then once week. Six group. Results It revealed volume eluted cefotaxime PMMA series higher than RK all concentrations. turn, vancomycin meropenem, it observed only group 1 samples. For groups 0.5 0.25, larger released noted series. found an effective (therapeutic) concentration more prolonged. there prolonged concentrations but smaller Discussion Each material showed its own elution profile them may have indications. RK-based has advantages terms duration doses. Conclusion studied longer PMMA-based material.

Language: Английский

Citations

0