Combination of scaffold with adipose-derived mesenchymal stem cell on knee joint cartilage defects: A literature review DOI Open Access
Aliefio Japamadisaw, Kukuh Dwiputra Hernugrahanto, Dwikora Novembri Utomo

et al.

Edelweiss Applied Science and Technology, Journal Year: 2024, Volume and Issue: 8(6), P. 9592 - 9604

Published: Dec. 31, 2024

Knee joint cartilage defects are a significant clinical challenge due to the limited regenerative capacity of articular cartilage, often leading degeneration and osteoarthritis (OA). Conventional treatment methods, such as surgical repair conservative management, frequently fail restore function fully. In recent years, scaffold-based tissue engineering using adipose-derived mesenchymal stem cells (ADMSCs) has emerged promising strategy for regeneration. ADMSCs, known their abundant availability, ease isolation, chondrogenic potential, provide viable cellular source repairing damaged cartilage. When combined with biocompatible scaffolds, ADMSCs can enhance regeneration by promoting cell proliferation, differentiation, extracellular matrix (ECM) formation at injury site. Various scaffold materials, including natural synthetic polymers, have been explored structural support necessary attachment formation. This literature review examines current advancements in application ADMSC-loaded scaffolds knee defects, focusing on biological properties, designs, outcomes preclinical studies. The also addresses challenges, degradation, mechanical migration, that must be optimized successful translation. Overall, this highlights potential ADMSC-based systems offer solution provides insights into future directions improving therapeutic strategies engineering.

Language: Английский

A Comprehensive Review of Stimuli-Responsive Smart Polymer Materials—Recent Advances and Future Perspectives DOI Open Access
Alicja Balcerak, Monika Dzwonkowska-Zarzycka, Janina Kabatc

et al.

Materials, Journal Year: 2024, Volume and Issue: 17(17), P. 4255 - 4255

Published: Aug. 28, 2024

Today, smart materials are commonly used in various fields of science and technology, such as medicine, electronics, soft robotics, the chemical industry, automotive field, many others. Smart polymeric hold good promise for future due to their endless possibilities. This group advanced can be sensitive changes or presence chemical, physical, biological stimuli, e.g., light, temperature, pH, magnetic/electric pressure, microorganisms, bacteria, viruses, toxic substances, review concerns newest achievements area materials. The recent advances designing stimuli-responsive polymers described this paper.

Language: Английский

Citations

8
Inorganic-Based Nanoparticles and Biomaterials as Biocompatible Scaffolds for Regenerative Medicine and Tissue Engineering: Current Advances and Trends of Development DOI Creative Commons
Nabanita Saikia

Inorganics, Journal Year: 2024, Volume and Issue: 12(11), P. 292 - 292

Published: Nov. 11, 2024

Regenerative medicine amalgamates stem cell technology and tissue engineering strategies to replace tissues organs damaged by injury, aging, ailment, and/or chronic conditions leveraging the innate self-healing mechanism of body. The term ‘regenerative medicine’ was coined William A. Haseltine during a 1999 conference on Lake Como. Since its inception in 1968, field has offered clinical benefits for regeneration, repair, restoration bones, skin, cartilage, neural tissue, heart, as well scaffold fabrication. regenerative can vastly benefit from advancements nanoscience technology, particularly fabrication application inorganic-based nanoparticles bionanomaterials. Due tunable intrinsic properties, i.e., size, topography, surface charge, chemical stability, biomaterials have surpassed traditional synthetic materials. Given wide gamut near-future applications inorganic biomaterials, this article gives an overview emerging roles research, engineering, artificial skin cartilage nerve injuries, 3D bioprinting, development new bio-scaffolds. review also addresses challenges related compatibility utilizing current state-of-the-art techniques.

Language: Английский

Citations

4
Advancements in Bone Replacement Techniques–Potential Uses After Maxillary and Mandibular Resections Due to Medication-Related Osteonecrosis of the Jaw (MRONJ) DOI Creative Commons

Judit Bóvári‐Biri,

Judith A Miskei,

Zsanett Kövér

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(2), P. 145 - 145

Published: Jan. 20, 2025

Maxillofacial bone defects can have a profound impact on both facial function and aesthetics. While various biomaterial scaffolds shown promise in addressing these challenges, regenerating this region remains complex due to its irregular shape, intricate structure, differing cellular origins compared other bones the human body. Moreover, significant variable mechanical loads placed maxillofacial add further complexity, especially cases of difficult-to-treat medical conditions. This review provides brief overview medication-related osteonecrosis jaw (MRONJ), highlighting medication-induced adverse reactions associated clinical challenges treating condition. The purpose manuscript is emphasize role biotechnology tissue engineering technologies therapy. By using scaffold materials biofactors combination with autologous cells, innovative solutions are explored for repair damaged bones. ongoing search effective that address improve vitro preparation subsequent regeneration critical. primary spotlight current research trends novel approaches area.

Language: Английский

Citations

0
Betaine enhances SCAPs chondrogenic differentiation and promotes cartilage repair in TMJOA through WDR81 DOI Creative Commons
Meiyue Wang, Zhaoming Wu, Xiaoyu Zheng

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 7, 2025

The cartilage tissue regeneration mediated with mesenchymal stem cells (MSCs) is considered as a viable strategy for temporomandibular joint osteoarthritis (TMJOA). Betaine has been confirmed to modulate the multidirectional differentiation of MSCs, while its effect on chondrogenic Stem Cells from Apical Papilla (SCAPs) unknown. Here, we explored effects and underlying mechanisms betaine SCAPs. was added SCAPs induction. potential assessed using Alcian Blue staining, Sirius Red staining main markers. In vivo were evaluated by rat TMJOA model. RNA-sequencing biological analyses performed select target genes processes involved. mechanism acts further explored. Betain-treated demonstrated stronger in vitro promoted repair vivo. enhanced expression WDR81 during chondrogenesis. overexpression SCAPs, depletion inhibited differentiation. addition, both treatment reduced intracellular reactive oxygen species levels increased mitochondrial membrane promotes provided an effective candidate treatment. may serve drug through mitophagy.

Language: Английский

Citations

0
Grem1 inhibits osteogenic differentiation of MBMSCs in OVX rats through BMP/Smad1/5 signaling pathway DOI Creative Commons
Shanshan Yang,

Min LinHu,

Xiaohua Hu

et al.

Regenerative Therapy, Journal Year: 2025, Volume and Issue: 28, P. 527 - 535

Published: Feb. 8, 2025

Language: Английский

Citations

0
Biomimetic ECM hydrogels loaded with ADSCs and polydopamine nanoparticles for chronic wound healing DOI
Jiaye Li, Fengyuan Wang, Youjun Ding

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160764 - 160764

Published: Feb. 1, 2025

Language: Английский

Citations

0
Multifaceted Exploration of Wood Biomass-Derived Nanomaterials for Biomedicine Approach DOI
K. Anbarasu,

Mary Anjalin Francis,

S. Madhu

et al.

Regenerative Engineering and Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Language: Английский

Citations

0
Protein to biomaterials: Unraveling the antiviral and proangiogenic activities of Ac-Tβ1-17 peptide, a thymosin β4 metabolite, and its implications in peptide-scaffold preparation DOI
Khandoker Asiqur Rahaman,

Md Sofequl Islam Mukim,

Md Lemon Hasan

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 437 - 455

Published: March 19, 2025

Language: Английский

Citations

0
Probiotics and nanoparticle-mediated nutrient delivery in the management of transfusion-supported diseases DOI Creative Commons

Wendao Han,

Nating Xiong,

Li‐Min Huang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 11, 2025

Bone marrow is vital for hematopoiesis, producing blood cells essential oxygen transport, immune defense, and clotting. However, disorders like leukemia, lymphoma, aplastic anemia, myelodysplastic syndromes can severely disrupt its function, leading to life-threatening complications. Traditional treatments, including chemotherapy stem cell transplants, have significantly improved patient outcomes but are often associated with severe side effects limitations, necessitating the exploration of safer, more targeted therapeutic strategies. Nanotechnology has emerged as a promising approach addressing these challenges, particularly in delivery nutraceuticals—bioactive compounds derived from food sources potential benefits. Despite their promise, nutraceuticals face clinical limitations due poor bioavailability, instability, inefficient target sites. Nanoparticles offer viable solution by enhancing stability, absorption, transport bone while minimizing systemic effects. This study explores range disorders, conventional treatment modalities, nanoparticles enhance nutraceutical-based therapies. By improving efficacy, could revolutionize disease management, providing patients effective less invasive options. These advancements represent significant step toward safer efficient approaches, ultimately prognosis overall health.

Language: Английский

Citations

0
Toward the Production of Hydroxyapatite/Poly(Ether-Ether-Ketone) (PEEK) Biocomposites: Exploring the Physicochemical, Mechanical, Cytotoxic and Antimicrobial Properties DOI Open Access

Meirilany Rozeno Costa,

José Adeilton Carvalho Filho,

Carlos Bruno Barreto Luna

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(17), P. 2520 - 2520

Published: Sept. 5, 2024

The development of hydroxyapatite (HAp) and polyether ether ketone (PEEK) biocomposites has been extensively studied for bone repair applications due to the synergistic properties involved materials. In this study, we aimed develop HAp/PEEK using high-energy ball milling, with HAp concentrations (20%, 40%, 60% w/v) in PEEK, evaluate their physicochemical, mechanical, cytotoxicity, antimicrobial potential Tissue Engineering (TE). were characterized by structure, morphology, apparent porosity, diametral compression strength, activity. study results demonstrated that successfully synthesized. C2 biocomposite, containing 40% HAp, stood out optimal distribution particles PEEK matrix, resulting higher strength (246 MPa) a homogeneous microstructure. It exhibited activity against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, no cytotoxicity observed. These make biocomposite promising regenerative medicine applications, combining mechanical bioactivity, biocompatibility.

Language: Английский

Citations

3