Injectable hydrogels with ROS-triggered drug release enable the co-delivery of antibacterial agent and anti-inflammatory nanoparticle for periodontitis treatment

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 12, 2025

Periodontitis, a chronic inflammatory disease caused by bacteria, is characterized localized reactive oxygen species (ROS) accumulation, leading to an response, which in turn leads the destruction of periodontal supporting tissues. Therefore, antibacterial, scavenging ROS, reducing regulating microenvironment, and alleviating alveolar bone resorption are effective methods treat periodontitis. In this study, we developed ROS-responsive injectable hydrogel modifying hyaluronic acid with 3-amino phenylboronic (PBA) reacting it poly(vinyl alcohol) (PVA) form borate bond. addition, encapsulated antibacterial agent minocycline hydrochloride (MH) Fe-Quercetin anti-inflammatory nanoparticles (Fe-Que NPs) for on-demand drug release response periodontitis microenvironment. This (HP-PVA@MH/Fe-Que) exhibited highly properties. Moreover, modulating Nrf2/NF-κB pathway, effectively eliminated ROS promoted macrophage polarization M2 phenotype, inflammation enhancing osteogenic differentiation potential human ligament stem cells (hPDLSCs) Animal studies showed that HP-PVA@MH/Fe-Que significantly reduced loss enhanced factor expression killing bacteria inhibiting inflammation. Thus, had efficient ROS-scavenging, anti-inflammatory, resorption-alleviation abilities, showing excellent application healing.

Language: Английский

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Mesoporous silica micro/nanomotors: A new horizon in biomedical applications and precision medicine

Applied Materials Today, Journal Year: 2025, Volume and Issue: 43, P. 102673 - 102673

Published: March 13, 2025

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A gel track-assisted light-driven micromotor system moving on complex solid substrates for visually targeted biofilm eradication and dental caries prevention

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161844 - 161844

Published: March 1, 2025

Language: Английский

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Cyclodextrin-based self-assembling hydrogel for Photothermal-controlled nitric oxide release in stage-specific treatment of MRSA-induced arthritis

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123578 - 123578

Published: April 1, 2025

Language: Английский

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Advances of functional nanomaterials as either therapeutic agents or delivery systems in the treatment of periodontitis

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 175, P. 214326 - 214326

Published: April 27, 2025

Language: Английский

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Injectable sodium alginate/4-arm polyethylene glycol-lipoic acid double-network hydrogel loading Ca2+-tannic acid nanocomposite treats periodontitis via anti-bacteria, ROS scavenging and osteogenesis

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 307, P. 141841 - 141841

Published: March 8, 2025

Language: Английский

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Therapeutic effects of tripterygium glycosides on periodontitis: Exploring the role of ursolic acid and the RIPK3/NLRP3 signaling pathway

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 146, P. 113903 - 113903

Published: Dec. 26, 2024

Periodontitis, a chronic inflammatory disease, poses challenges in treatment due to its complex etiology. Tripterygium glycosides (TGs), renowned for their immunosuppressive and anti-inflammatory capabilities, present prospective therapeutic option the management of periodontitis. This study delves into efficacy TGs periodontitis reveals fundamental mechanisms involved.

Language: Английский

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