Recent advances and future prospects of engineered exosomes as advanced drug and gene delivery systems

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106696 - 106696

Published: Feb. 6, 2025

Language: Английский

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Injectable Nanocomposite Hydrogel for Accelerating Diabetic Wound Healing Through Inflammatory Microenvironment Regulation

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1679 - 1696

Published: Feb. 1, 2025

Background: A paramount issue in the realm of chronic wound healing among diabetic patients is pervasive inflammatory response that persistently thwarts angiogenesis, thereby precipitating protracted delays process such wounds. Employing zeolitic imidazolate framework-8 (ZIF-8) as a drug delivery platform, integrated within temperature-sensitive injectable hydrogel, presents an intriguing strategy for closure various irregular wounds, modulation responses, and promotion angiogenesis. Methods: Herein, ZIF-8 loaded with curcumin (Cur) combined methylcellulose/carboxymethyl chitosan (MCC) thermosensitive hydrogel was described. The assessment encompassed properties, pH-responsive release, antimicrobial activity, ROS scavenging capabilities MCC@ZIF-8@Cur hydrogel. series studies were conducted to explore its biocompatibility, pro-angiogenic effects, macrophage M2 polarization induction. Additionally, full-thickness skin defect model rat established investigate hydrogel's multifaceted efficacy facilitating repair, mitigating fostering Results: possess attribute being capable situ formation (gelation temperature ≥ 28 °C), establishing effective physical barrier multitude profiles. incorporation ZIF-8@Cur confers exceptional antibacterial properties capability eliminate reactive oxygen species (ROS). Moreover, continuously releases Cur Zn 2+ , inflammation, inducing macrophages, promoting This creates favorable immune microenvironment conducive regeneration, accelerating In vivo have demonstrated markedly accelerated ratio rats group compared Control ( p < 0.001). By 14th day healing, achieved remarkable 97.22%, considerably surpassing (72.98%), showcasing potential treating Conclusion: findings demonstrate successful creation exhibits capabilities. effectively suppresses modulates macrophages towards phenotype, promotes thus regeneration. These attributes collectively augur promising prospects applications Keywords: wound, microenvironment, polarization, angiogenesis

Language: Английский

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Dissolving microneedles: drug delivery and disease treatment

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114571 - 114571

Published: Feb. 1, 2025

Language: Английский

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Targeted delivery of extracellular vesicles: the mechanisms, techniques and therapeutic applications

Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)

Published: Nov. 21, 2024

Abstract Extracellular vesicles (EVs) are cell-derived with a phospholipid bilayer measuring 50–150 nm in diameter demonstrated therapeutic potentials. Limitations such as the natural biodistribution (mainly concentrated liver and spleen) short plasma half-life of EVs present significant challenges to their clinical translation. In recent years, growing research indicated that engineered enhanced targeting lesion sites have markedly promoted efficacy. However, there is dearth systematic knowledge on advances engineering for targeted delivery. Herein, we provide an overview mechanisms, techniques, translations applications. Enrichment at may be achieved through recognition tissue markers, pathological changes, circumvention mononuclear phagocyte system (MPS). Alternatively, external stimuli, including magnetic fields ultrasound, also employed. EV techniques fulfill functions includes genetic engineering, membrane fusion, chemical modification physical modification. A comparative statistical analysis was conducted elucidate discrepancies between diverse size, morphology, stability, efficacy vitro vivo. Additionally, summary registered trials utilizing from 2010 2023 has been provided, full discussion perspectives. This review provides comprehensive mechanisms associated delivery applications advocate further explorations accelerate

Language: Английский

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Anisotropic structure of nanofiber hydrogel accelerates diabetic wound healing via triadic synergy of immune-angiogenic-neurogenic microenvironments

Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 64 - 82

Published: Jan. 11, 2025

Language: Английский

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The efficacy of platelet-derived extracellular vesicles in the treatment of diabetic wounds: a systematic review and meta-analysis of animal studies

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Jan. 15, 2025

Language: Английский

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Microneedle hierarchical structure construction for promoting multi-stage wound healing

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125474 - 125474

Published: March 1, 2025

Language: Английский

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Multifunctional Dual-Layer Microneedles Loaded with Selenium-Doped Carbon Quantum Dots and Astilbin for Ameliorating Diabetic Wound Healing

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101739 - 101739

Published: April 1, 2025

Language: Английский

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Porcine pericardial decellularized matrix bilayer patch containing adipose stem cell-derived exosomes for the treatment of diabetic wounds

Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101398 - 101398

Published: Dec. 10, 2024

Language: Английский

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