Microenvironment‐Responsive Injectable Thermosensitive Hydrogel Incorporating Nanozymes for Synergistic Breast Cancer Therapy and Postsurgical Adjuvant Treatment DOI
Peng Hu, Na Feng, Shuang Zhao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Abstract Tumor recurrence and wound infection present significant challenges to patient recovery following surgery, underscoring the need for effective therapeutic strategies improve prognosis by mitigating these complications. This study introduces novel synthesis methods honeycomb‐like CuMnOx nanozymes CuO 2 nanoflowers with multienzymatic activity pH‐responsive properties. The enzymatic activities of can be regulated pH changes in tumor or microenvironments, while overcome limitation insufficient endogenous H O release ROS weakly acidic conditions. To realize their synergistic effects, nanozymes, along photothermal agent IR820, are co‐assembled into low‐melting point agarose solution, forming a thermosensitive nanozyme‐based hydrogel (CuMnOx@CuO @IR820 hydrogel, CMCI Gel), which facilitates controlled drug delivery exerts enhanced efficiency under low‐temperature therapy (LTPTT, <48 °C). In vitro vivo studies demonstrated that Gel effectively ablated cells range bacteria, including drug‐resistant bacteria like MRSA . Furthermore, it reduces inflammation, promotes vascular regeneration collagen deposition, accelerates healing. injectability thermosensitivity allow localized treatment, minimizing systemic side effects. Overall, benefits highlight as promising adjunctive prevent postsurgery infection.

Language: Английский

Metabolomic exploration of the effect of tetrodotoxin on metabolism in Takifugu rubripes ovaries DOI

Y S Lu,

Teng Teng,

Zhecheng Zhao

et al.

Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742389 - 742389

Published: March 1, 2025

Language: Английский

Citations

0
Non‐Porous Hydrogel Scaffolds for Locoregional Chemotherapy: A One‐Pot Synthesis Approach DOI Creative Commons
Sadık Kağa, Gizem Fatma Erguner

Macromolecular Materials and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Abstract Although surgery is common in the treatment of solid tumors cancer, risk recurrence after operation high malignant tumors. This study focuses on fabricating doxorubicin‐loaded, non‐porous POEGMEMA (Poly(oligo(ethylene glycol) methyl ether methacrylate)) and PLGA (Poly(D,L‐lactide‐co‐glycolide))/POEGMEMA scaffolds for locoregional chemotherapy. Polymer synthesis, hydrogel formation, drug‐loading processes are performed using a one‐pot approach. The were characterized by mechanical, swelling, degradation, release tests. 10% content, causes PLGA/POEGMEMA to give 2.5 times lower swelling ratio sixfold higher compression stress than scaffolds. Also, addition an increase biodegradation half‐life POEGMEMA‐based While exhibit degradation‐dependent profile, burst due their water uptake ratio. behavior antiproliferative effect (viable cells: 5–10%) against HT‐29 MCF‐7 cancer cells short term. In contrast, controlled sustained profile shows 50–60%) dependent scaffold platform allows tuning physical functional properties deal with diverse physiological conditions at region tumor

Language: Английский

Citations

0
Microenvironment‐Responsive Injectable Thermosensitive Hydrogel Incorporating Nanozymes for Synergistic Breast Cancer Therapy and Postsurgical Adjuvant Treatment DOI
Peng Hu, Na Feng, Shuang Zhao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Abstract Tumor recurrence and wound infection present significant challenges to patient recovery following surgery, underscoring the need for effective therapeutic strategies improve prognosis by mitigating these complications. This study introduces novel synthesis methods honeycomb‐like CuMnOx nanozymes CuO 2 nanoflowers with multienzymatic activity pH‐responsive properties. The enzymatic activities of can be regulated pH changes in tumor or microenvironments, while overcome limitation insufficient endogenous H O release ROS weakly acidic conditions. To realize their synergistic effects, nanozymes, along photothermal agent IR820, are co‐assembled into low‐melting point agarose solution, forming a thermosensitive nanozyme‐based hydrogel (CuMnOx@CuO @IR820 hydrogel, CMCI Gel), which facilitates controlled drug delivery exerts enhanced efficiency under low‐temperature therapy (LTPTT, <48 °C). In vitro vivo studies demonstrated that Gel effectively ablated cells range bacteria, including drug‐resistant bacteria like MRSA . Furthermore, it reduces inflammation, promotes vascular regeneration collagen deposition, accelerates healing. injectability thermosensitivity allow localized treatment, minimizing systemic side effects. Overall, benefits highlight as promising adjunctive prevent postsurgery infection.

Language: Английский

Citations

0