Novel hollow ultrasound-triggered ZnFe2O4-Bi2MoO6 S-scheme heterojunction for efficient ferroptosis-based tumor therapy DOI
Wenting Li,

Zhuoran Yang,

Chunyu Yang

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 683, P. 132 - 146

Published: Dec. 10, 2024

Language: Английский

Multifunctional glycyrrhizic acid-loaded nanoplatform combining ferroptosis induction and HMGB1 blockade for enhanced tumor immunotherapy DOI Creative Commons
Xianyi Sha, Chuanbing Wang, Yan Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 19, 2025

Inducing ferroptotic cell death has been recognized as a promising approach in cancer therapy. However, ferroptosis can provoke tumor infiltration by myeloid-derived suppressor cells (MDSCs) through HMGB1 secretion, causing suppressive immune response. On the other hand, also occurs due to its non-selective properties, which compromise anti-tumor immunity. To address these challenges, two-pronged is proposed, encompassing selectively triggered and blockade, aimed at eliciting systemic immunity alleviating immunosuppression. Herein, GSH-specific driven nanoplatform composed of uniform FeOOH nanospindles coated with tetrasulfide bond-bridged mesoporous organosilica (DMOS) shell, loaded inhibitor, glycyrrhizic acid (GA). This endowed high glutathione (GSH) depletion efficiency exhibits highly efficient Fe2+ ROS generation capacity, promotes accumulation LPO subsequently induces ferroptosis. Concurrently, inhibition release counteracts immunosuppressive effects within microenvironment. innovative effectively suppresses growth 4T1 tumors notably enhancing therapeutic outcomes checkpoint blockade across experimental data. The collective findings indicate potential reliable strategy for boosting ferroptosis-mediated favorable safety profiles.

Language: Английский

Citations

0
Therapeutic application of nanosystems-based metalloptosis for enhanced tumor radiotherapy DOI

Meili Chen,

Ling Chen,

Kun Mao

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 536, P. 216666 - 216666

Published: April 10, 2025

Language: Английский

Citations

0
Calcium peroxide functionalized mesoporous polydopamine nanoparticles triggered calcium overload for synergistic tumor gas/photothermal therapy DOI
Zhen Liu, Wei Hu, Yingying Cai

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 690, P. 137332 - 137332

Published: March 14, 2025

Language: Английский

Citations

0
Novel hollow ultrasound-triggered ZnFe2O4-Bi2MoO6 S-scheme heterojunction for efficient ferroptosis-based tumor therapy DOI
Wenting Li,

Zhuoran Yang,

Chunyu Yang

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 683, P. 132 - 146

Published: Dec. 10, 2024

Language: Английский

Citations

0