The emerging role of honeysuckle flower in inflammatory bowel disease

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 28, 2025

Crohn's disease (CD) and ulcerative colitis (UC), referred to as inflammatory bowel (IBD), pose considerable challenges in treatment because they are chronic conditions that easily relapse. The occurrence of IBD continues rise developing countries. Nonetheless, the existing therapies for have limitations fail address needs patients thoroughly. There is an increasing need new, safe, highly effective alternative medications patients. Traditional Chinese Medicine (TCM) employed drug development management due its wide-range biological activities, minimal toxicity, limited side effects. Extensive research has shown certain TCM exhibits significant therapeutic benefits treatments. Honeysuckle (Lonicera japonica) was used clinical settings IBD. Bioactive metabolites L. japonica, such luteolin, quercetin, cyanidin, chlorogenic acid (CGA), caffeic (CA), saponin, exhibit managing honeysuckle flower a potential candidate anti-inflammatory, immune system-regulating, antioxidant qualities. This paper reviews It discusses fundamental mechanism japonica bioactive prevention

Language: Английский

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Unraveling the Impact of Micro- and Nano-sized Polymethyl methacrylate on Gut Microbiota and Liver Lipid Metabolism: Insights from Oral Exposure Studies

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126157 - 126157

Published: March 1, 2025

Language: Английский

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Synergistic Anti-Inflammatory Effects of Pomegranate Peel–Hawthorn Combinations in Ulcerative Colitis: Network Pharmacology Prediction and Experimental Validation

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 243 - 243

Published: April 1, 2025

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by complex pathogenesis involving dysregulated immunity and gut microbiota imbalance, demanding innovative therapeutic strategies. This study investigates the synergistic potential of pomegranate peel–hawthorn combinations their active constituents (ellagic acid maslinic acid) through an integrative approach combining network pharmacology, in vitro/in vivo experiments, analysis. Network pharmacology identified 61 shared targets (p < 0.05 for pathway enrichment) revealed complementary mechanisms: peel primarily modulated AGE-RAGE/PI3K-Akt pathways, while hawthorn targeted IL-17/NF-κB signaling. Experimental validation demonstrated potent anti-inflammatory effects (combination index 1), with optimal reducing nitric oxide production 52.35% (herbal extracts, p 0.05) 74.4% (active monomers, 0.05). In DSS-induced UC mice, combinatorial therapies significantly suppressed pro-inflammatory cytokines (TNF-α: 204.78 vs. 446.52 pg/mL group, 0.05; IL-6: 33.19 64.86 pg/mL, 0.05), restored colonic SOD activity (72.31 50.10 U/mg·prot 0.01), alleviated histopathological damage, outperforming monotherapeutics. Gut analysis recovery α-diversity indices normalized Bacteroidota/Bacillota ratios. Mechanistically, MAPK/NF-κB signaling cascades, p-p38/p38 0.01 group) p-ERK1/2/ERK1/2 phosphorylation. These findings establish that formulations exert multi-modal inhibition mitigation oxidative stress, restoration microbiota, offering scientifically validated management rooted traditional medicine principles.

Language: Английский

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Recent advances in tea and other plant polyphenol biomaterials for antibacterial and disease treatment

Beverage Plant Research, Journal Year: 2025, Volume and Issue: 5(1), P. 0 - 0

Published: Jan. 1, 2025

Language: Английский

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NUDT1 aggravates intestinal epithelial barrier injury through oxidative stress in ulcerative colitis

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114634 - 114634

Published: April 10, 2025

Language: Английский

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