Current Status and Perspectives of Research on Polymer Hydrogels in the Treatment and Protection of Osteoarthritis DOI
Wanjun Liang, Ruey‐Jen Yang,

Lijing Qin

et al.

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Arthritis is a degenerative disease characterized by chronic cartilage degeneration. It affects hundreds of millions people worldwide and often has serious consequences such as joint pain swelling, limited mobility, deformity. However, conventional treatments still struggle to achieve satisfactory results. Finding more effective for arthritis remains an important clinical challenge. As hydrogels have unique 3D spatial mesh structure, significant material interaction ability, adjustable mechanical properties, good biodegradability, they can provide suitable cellular or tissue microenvironment, their potential in scaffolding effect, lubrication, anti‐inflammatory drug delivery expected be potent therapeutic approach the treatment osteoarthritis. In this review, three aspects hydrogel products osteoarthritis are comprehensively summarized discussed, namely, selection gel design, exploration cross‐linking mechanisms, mechanisms therapy osteoarthritis, focus on advantages limitations applications, which point out direction development strategy innovative field, applied research, transformation.

Language: Английский

Advances of novel hydrogels in the healing process of alveolar sockets DOI

Wu-Liang Yu,

Liwei Hu, Yige Wei

et al.

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 173, P. 214280 - 214280

Published: March 9, 2025

Language: Английский

Citations

0
Composite cryogel of gelatin/nanofibrillated cellulose/partially demineralized chitin with potential for bone tissue engineering DOI

Maryam Sadat Adibhosseini,

Ebrahim Vasheghani‐Farahani, Sameereh Hashemi‐Najafabadi

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142019 - 142019

Published: March 1, 2025

Language: Английский

Citations

0
A Pro-Healing and Antibacterial Bio-Based Hydrogel Barrier for the Prevention of Intestinal Anastomotic Leakage DOI

Yiheng Ju,

Dongjie Zhang,

Huijie Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 5, 2025

Postoperative leakage at the colorectal anastomosis is recognized as a significant and serious complication. Its pathogenic factors are complex, onset process hidden, it often complicated with severe abdominal infection, which leads to sepsis even multiple organ failure. In order develop new type of multifunctional biomaterial can prevent intestinal bacterial translocation, fluid spillage promote healing anastomosis, we prepared temperature-sensitive extracellular matrix hydrogel (ECM) porcine small submucosa (SIS) physically modified by boric acid 4-ARM-PEG-SC raw materials, in avoid infection anastomotic leakage. A series experiments showed that had stable structure, could resist erosion digestive juice physiological range good tissue adhesion mechanical properties, excellent antiexplosion ability self-healing. Combined its injectability, effectively seal anastomosis. vitro effective antidigestion ability, antibacterial cell blood compatibility, well antioxidant anti-inflammatory capabilities. Experiments revealed optimize local microenvironment repair reduce incidence colonic rats promoting key proliferation, facilitating vascular formation curtailing expression pro-inflammatory factors. The findings this study pave way for novel strategies creating materials designed manage

Language: Английский

Citations

0
Current Status and Perspectives of Research on Polymer Hydrogels in the Treatment and Protection of Osteoarthritis DOI
Wanjun Liang, Ruey‐Jen Yang,

Lijing Qin

et al.

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Arthritis is a degenerative disease characterized by chronic cartilage degeneration. It affects hundreds of millions people worldwide and often has serious consequences such as joint pain swelling, limited mobility, deformity. However, conventional treatments still struggle to achieve satisfactory results. Finding more effective for arthritis remains an important clinical challenge. As hydrogels have unique 3D spatial mesh structure, significant material interaction ability, adjustable mechanical properties, good biodegradability, they can provide suitable cellular or tissue microenvironment, their potential in scaffolding effect, lubrication, anti‐inflammatory drug delivery expected be potent therapeutic approach the treatment osteoarthritis. In this review, three aspects hydrogel products osteoarthritis are comprehensively summarized discussed, namely, selection gel design, exploration cross‐linking mechanisms, mechanisms therapy osteoarthritis, focus on advantages limitations applications, which point out direction development strategy innovative field, applied research, transformation.

Language: Английский

Citations

0