Materials Horizons,
Journal Year:
2023,
Volume and Issue:
10(11), P. 4903 - 4913
Published: Jan. 1, 2023
Conversion
between
mechanical
and
electrical
cues
is
usually
considered
unidirectional
in
cells
with
cardiomyocytes
being
an
exception.
Here,
we
discover
a
material-induced
external
electric
field
(Eex)
triggers
electro-mechanical
coupling
feedback
loop
other
than
cardiomyocytes,
human
umbilical
vein
endothelial
(HUVECs),
by
opening
their
mechanosensitive
Piezo1
channels.
When
HUVECs
are
cultured
on
patterned
piezoelectric
materials,
the
materials
generate
Eex
(confined
at
cellular
scale)
to
polarize
intracellular
calcium
ions
([Ca2+]i),
forming
built-in
(Ein)
opposing
Eex.
Furthermore,
[Ca2+]i
polarization
stimulates
shrink
cytoskeletons,
activating
channels
induce
influx
of
extracellular
Ca2+
that
gradually
increases
Ein
balance
Such
directs
pre-angiogenic
activities
such
as
alignment,
elongation,
migration
HUVECs.
Activated
dynamics
during
further
modulate
downstream
angiogenesis-inducing
eNOS/NO
pathway.
These
findings
lay
foundation
for
developing
new
ways
stimulation-based
disease
treatment.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(17), P. 8632 - 8712
Published: Jan. 1, 2024
Bioelectronics
is
a
hot
research
topic,
yet
an
important
tool,
as
it
facilitates
the
creation
of
advanced
medical
devices
that
interact
with
biological
systems
to
effectively
diagnose,
monitor
and
treat
broad
spectrum
health
conditions.
Electrical
stimulation
(ES)
pivotal
technique
in
bioelectronics,
offering
precise,
non-pharmacological
means
modulate
control
processes
across
molecular,
cellular,
tissue,
organ
levels.
This
method
holds
potential
restore
or
enhance
physiological
functions
compromised
by
diseases
injuries
integrating
sophisticated
electrical
signals,
device
interfaces,
designs
tailored
specific
mechanisms.
review
explains
mechanisms
which
ES
influences
cellular
behaviors,
introduces
essential
principles,
discusses
performance
requirements
for
optimal
systems,
highlights
representative
applications.
From
this
review,
we
can
realize
based
bioelectronics
therapy,
regenerative
medicine
rehabilitation
engineering
technologies,
ranging
from
tissue
neurological
modulation
cardiovascular
cognitive
functions.
underscores
versatility
various
biomedical
contexts
emphasizes
need
adapt
complex
clinical
landscapes
addresses.
Journal of Orthopaedic Translation,
Journal Year:
2024,
Volume and Issue:
47, P. 191 - 206
Published: June 27, 2024
The
regenerative
capacity
of
bone
is
indispensable
for
growth,
given
that
accidental
injury
almost
inevitable.
Bone
relevant
the
aging
population
globally
and
repair
large
defects
after
osteotomy
(e.g.,
following
removal
malignant
tumours).
Among
many
therapeutic
modalities
proposed
to
regeneration,
electrical
stimulation
has
attracted
significant
attention
owing
its
economic
convenience
exceptional
curative
effects,
various
electroactive
biomaterials
have
emerged.
This
review
summarizes
current
knowledge
progress
regarding
strategies
improving
repair.
Such
range
from
traditional
methods
delivering
via
electroconductive
materials
using
external
power
sources
self-powered
biomaterials,
such
as
piezoelectric
nanogenerators.
Electrical
osteogenesis
are
related
piezoelectricity.
examines
cell
behaviour
potential
mechanisms
electrostimulation
in
healing,
aiming
provide
new
insights
regeneration
biomaterials.
roles
rehabilitating
microenvironment
facilitate
addressing
whereby
cues
mediate
regeneration.
Interactions
between
osteogenesis-related
cells
summarized,
leading
proposals
use
stimulation-based
therapies
accelerate
healing.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 5, 2025
MXene-based
materials
have
attracted
significant
interest
due
to
their
distinct
physical
and
chemical
properties,
which
are
relevant
fields
such
as
energy
storage,
environmental
science,
biomedicine.
MXene
has
shown
potential
in
the
area
of
tissue
regenerative
medicine.
However,
research
on
its
applications
regeneration
is
still
early
stages,
with
a
notable
absence
comprehensive
reviews.
This
review
begins
detailed
description
intrinsic
properties
MXene,
followed
by
discussion
various
nanostructures
that
can
form,
spanning
from
0
3
dimensions.
The
focus
then
shifts
biomaterials
engineering,
particularly
immunomodulation,
wound
healing,
bone
regeneration,
nerve
regeneration.
MXene's
physicochemical
including
conductivity,
photothermal
characteristics,
antibacterial
facilitate
interactions
different
cell
types,
influencing
biological
processes.
These
highlight
modulating
cellular
functions
essential
for
Although
developing,
versatile
structural
attributes
suggest
role
advancing
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Oct. 17, 2024
The
incidence
of
large
bone
defects
caused
by
traumatic
injury
is
increasing
worldwide,
and
the
tissue
regeneration
process
requires
a
long
recovery
time
due
to
limited
self-healing
capability.
Endogenous
bioelectrical
phenomena
have
been
well
recognized
as
critical
biophysical
factors
in
remodeling
regeneration.
Inspired
bioelectricity,
electrical
stimulation
has
widely
considered
an
external
intervention
induce
osteogenic
lineage
cells
enhance
synthesis
extracellular
matrix,
thereby
accelerating
With
ongoing
advances
biomaterials
energy-harvesting
techniques,
electroactive
self-powered
systems
biomimetic
approaches
ensure
functional
recapitulating
natural
electrophysiological
microenvironment
healthy
tissue.
In
this
review,
we
first
introduce
role
bioelectricity
endogenous
electric
field
summarize
different
techniques
electrically
stimulate
Next,
highlight
latest
progress
exploring
hybrid
such
triboelectric
piezoelectric-based
nanogenerators
photovoltaic
cell-based
devices
their
implementation
engineering.
Finally,
emphasize
significance
simulating
target
tissue's
propose
opportunities
challenges
faced
bioelectronics
for
repair
strategies.
Abstract
The
electrical
microenvironment
is
considered
a
pivotal
determinant
in
various
pathophysiological
processes,
including
tissue
homeostasis
and
wound
healing.
Consequently,
extensive
research
endeavors
have
been
directed
toward
applying
electricity
to
cells
tissues
through
external
force
devices
or
biomaterial-based
platforms.
In
addition
situ
electroconductive
matrices,
new
class
of
electroactive
biomaterials
responsive
stimuli
has
emerged
as
focal
point
interest.
These
materials,
response
intrinsic
biochemical
(e.g.,
glucose)
physical
light,
magnetism,
stress),
hold
significant
potential
for
cell
stimulation
regeneration.
this
communication,
we
underscore
distinct
category
biomaterials,
discussing
the
currently
developed
biomaterial
platforms
their
biological
roles
stimulating
during
healing
regeneration
process.
We
also
critically
evaluate
inherent
limitations
challenges
these
while
offering
forward-looking
insights
into
promise
future
clinical
translations.
Graphical
Science and Technology of Advanced Materials,
Journal Year:
2023,
Volume and Issue:
24(1)
Published: Aug. 24, 2023
Osteoporotic-related
fractures
are
among
the
leading
causes
of
chronic
disease
morbidity
in
Europe
and
US.
While
a
significant
percentage
can
be
repaired
naturally,
delayed-union
non-union
surgical
intervention
is
necessary
for
proper
bone
regeneration.
Given
current
lack
optimized
clinical
techniques
to
adequately
address
this
issue,
tissue
engineering
(BTE)
strategies
focusing
on
development
scaffolds
temporarily
replacing
damaged
supporting
its
regeneration
process
have
been
gaining
interest.
The
piezoelectric
properties
bone,
which
an
important
role
homeostasis
regeneration,
frequently
neglected
design
BTE
scaffolds.
Therefore,
study,
we
developed
novel
hydroxyapatite
(HAp)-filled
osteoinductive
poly(vinylidene
fluoride-co-tetrafluoroethylene)
(PVDF-TrFE)
nanofibers
via
electrospinning
capable
replicating
tissue's
fibrous
extracellular
matrix
(ECM)
composition
native
properties.
PVDF-TrFE/HAp
had
biomimetic
collagen
fibril-like
diameters,
as
well
enhanced
surface
properties,
translated
into
better
capacity
assist
mineralization
cell
proliferation.
biological
cues
provided
by
HAp
nanoparticles
osteogenic
differentiation
seeded
human
mesenchymal
stem/stromal
cells
(MSCs)
observed
increased
ALP
activity,
cell-secreted
calcium
deposition
gene
expression
levels
HAp-containing
fibers.
Overall,
our
findings
describe
potential
combining
PVDF-TrFE
developing
electroactive
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: March 5, 2024
Abstract
Electrical
stimulation
(ES)
has
been
described
as
a
promising
tool
for
bone
tissue
engineering,
being
known
to
promote
vital
cellular
processes
such
cell
proliferation,
migration,
and
differentiation.
Despite
the
high
variability
of
applied
protocol
parameters,
direct
coupled
electric
fields
have
successfully
osteogenic
osteoinductive
in
vitro
vivo.
Our
work
aims
study
viability,
differentiation
human
marrow-derived
mesenchymal
stem/stromal
cells
when
subjected
five
different
ES
protocols.
The
protocols
were
specifically
selected
understand
biological
effects
parts
generated
waveform
typical
direct-coupled
stimuli.
In
culture
studies
evidenced
variations
responses
with
field
magnitudes
(numerically
predicted)
exposure
protocols,
mainly
regarding
mineralization
(calcium
contents)
marker
gene
expression
while
maintaining
viability
regular
morphology.
Overall,
our
results
highlight
importance
numerical
guided
experiments
optimize
parameters
towards
improved
osteogenesis
