Electro-mechanical coupling directs endothelial activities through intracellular calcium ion deployment DOI
Changhao Li, Peng Yu, Zhengao Wang

et al.

Materials Horizons, Journal Year: 2023, Volume and Issue: 10(11), P. 4903 - 4913

Published: Jan. 1, 2023

Conversion between mechanical and electrical cues is usually considered unidirectional in cells with cardiomyocytes being an exception. Here, we discover a material-induced external electric field (Eex) triggers electro-mechanical coupling feedback loop other than cardiomyocytes, human umbilical vein endothelial (HUVECs), by opening their mechanosensitive Piezo1 channels. When HUVECs are cultured on patterned piezoelectric materials, the materials generate Eex (confined at cellular scale) to polarize intracellular calcium ions ([Ca2+]i), forming built-in (Ein) opposing Eex. Furthermore, [Ca2+]i polarization stimulates shrink cytoskeletons, activating channels induce influx of extracellular Ca2+ that gradually increases Ein balance Such directs pre-angiogenic activities such as alignment, elongation, migration HUVECs. Activated dynamics during further modulate downstream angiogenesis-inducing eNOS/NO pathway. These findings lay foundation for developing new ways stimulation-based disease treatment.

Language: Английский

Electrically stimulated 3D bioprinting of gelatin-polypyrrole hydrogel with dynamic semi-IPN network induces osteogenesis via collective signaling and immunopolarization DOI
Sayan Deb Dutta, Keya Ganguly, Aayushi Randhawa

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 294, P. 121999 - 121999

Published: Jan. 14, 2023

Language: Английский

Citations

47

Bioelectronics for electrical stimulation: materials, devices and biomedical applications DOI
Ya Huang, Kuanming Yao, Qiang Zhang

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(17), P. 8632 - 8712

Published: Jan. 1, 2024

Bioelectronics is a hot research topic, yet an important tool, as it facilitates the creation of advanced medical devices that interact with biological systems to effectively diagnose, monitor and treat broad spectrum health conditions. Electrical stimulation (ES) pivotal technique in bioelectronics, offering precise, non-pharmacological means modulate control processes across molecular, cellular, tissue, organ levels. This method holds potential restore or enhance physiological functions compromised by diseases injuries integrating sophisticated electrical signals, device interfaces, designs tailored specific mechanisms. review explains mechanisms which ES influences cellular behaviors, introduces essential principles, discusses performance requirements for optimal systems, highlights representative applications. From this review, we can realize based bioelectronics therapy, regenerative medicine rehabilitation engineering technologies, ranging from tissue neurological modulation cardiovascular cognitive functions. underscores versatility various biomedical contexts emphasizes need adapt complex clinical landscapes addresses.

Language: Английский

Citations

28

Advances in electroactive biomaterials: Through the lens of electrical stimulation promoting bone regeneration strategy DOI Creative Commons
Songyang Luo, Chengshuo Zhang, Wei Xiong

et al.

Journal of Orthopaedic Translation, Journal Year: 2024, Volume and Issue: 47, P. 191 - 206

Published: June 27, 2024

The regenerative capacity of bone is indispensable for growth, given that accidental injury almost inevitable. Bone relevant the aging population globally and repair large defects after osteotomy (e.g., following removal malignant tumours). Among many therapeutic modalities proposed to regeneration, electrical stimulation has attracted significant attention owing its economic convenience exceptional curative effects, various electroactive biomaterials have emerged. This review summarizes current knowledge progress regarding strategies improving repair. Such range from traditional methods delivering via electroconductive materials using external power sources self-powered biomaterials, such as piezoelectric nanogenerators. Electrical osteogenesis are related piezoelectricity. examines cell behaviour potential mechanisms electrostimulation in healing, aiming provide new insights regeneration biomaterials. roles rehabilitating microenvironment facilitate addressing whereby cues mediate regeneration. Interactions between osteogenesis-related cells summarized, leading proposals use stimulation-based therapies accelerate healing.

Language: Английский

Citations

23

Engineered MXene Biomaterials for Regenerative Medicine DOI

Shengmin Zhang,

Liang Wang, Zhichao Feng

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

MXene-based materials have attracted significant interest due to their distinct physical and chemical properties, which are relevant fields such as energy storage, environmental science, biomedicine. MXene has shown potential in the area of tissue regenerative medicine. However, research on its applications regeneration is still early stages, with a notable absence comprehensive reviews. This review begins detailed description intrinsic properties MXene, followed by discussion various nanostructures that can form, spanning from 0 3 dimensions. The focus then shifts biomaterials engineering, particularly immunomodulation, wound healing, bone regeneration, nerve regeneration. MXene's physicochemical including conductivity, photothermal characteristics, antibacterial facilitate interactions different cell types, influencing biological processes. These highlight modulating cellular functions essential for Although developing, versatile structural attributes suggest role advancing

Language: Английский

Citations

5

Unleashing the Potential of Electroactive Hybrid Biomaterials and Self-Powered Systems for Bone Therapeutics DOI Creative Commons
Shichang Liu, Farid Manshaii, Jinmiao Chen

et al.

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 17(1)

Published: Oct. 17, 2024

The incidence of large bone defects caused by traumatic injury is increasing worldwide, and the tissue regeneration process requires a long recovery time due to limited self-healing capability. Endogenous bioelectrical phenomena have been well recognized as critical biophysical factors in remodeling regeneration. Inspired bioelectricity, electrical stimulation has widely considered an external intervention induce osteogenic lineage cells enhance synthesis extracellular matrix, thereby accelerating With ongoing advances biomaterials energy-harvesting techniques, electroactive self-powered systems biomimetic approaches ensure functional recapitulating natural electrophysiological microenvironment healthy tissue. In this review, we first introduce role bioelectricity endogenous electric field summarize different techniques electrically stimulate Next, highlight latest progress exploring hybrid such triboelectric piezoelectric-based nanogenerators photovoltaic cell-based devices their implementation engineering. Finally, emphasize significance simulating target tissue's propose opportunities challenges faced bioelectronics for repair strategies.

Language: Английский

Citations

14

Biomaterials-enabled electrical stimulation for tissue healing and regeneration DOI Creative Commons
Han‐Sem Kim,

Tanza Baby,

Jung‐Hwan Lee

et al.

Med-X, Journal Year: 2024, Volume and Issue: 2(1)

Published: May 21, 2024

Abstract The electrical microenvironment is considered a pivotal determinant in various pathophysiological processes, including tissue homeostasis and wound healing. Consequently, extensive research endeavors have been directed toward applying electricity to cells tissues through external force devices or biomaterial-based platforms. In addition situ electroconductive matrices, new class of electroactive biomaterials responsive stimuli has emerged as focal point interest. These materials, response intrinsic biochemical (e.g., glucose) physical light, magnetism, stress), hold significant potential for cell stimulation regeneration. this communication, we underscore distinct category biomaterials, discussing the currently developed biomaterial platforms their biological roles stimulating during healing regeneration process. We also critically evaluate inherent limitations challenges these while offering forward-looking insights into promise future clinical translations. Graphical

Language: Английский

Citations

10

Fabrication and characterization of novel polyhydroxybutyrate-keratin/nanohydroxyapatite electrospun fibers for bone tissue engineering applications DOI
Pooriya Sarrami, Saeed Karbasi,

Zohreh Farahbakhsh

et al.

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 220, P. 1368 - 1389

Published: Sept. 15, 2022

Language: Английский

Citations

33

Hydroxyapatite-filled osteoinductive and piezoelectric nanofibers for bone tissue engineering DOI Creative Commons
Frederico Barbosa, Fábio F. F. Garrudo, Paola Sanjuan‐Alberte

et al.

Science and Technology of Advanced Materials, Journal Year: 2023, Volume and Issue: 24(1)

Published: Aug. 24, 2023

Osteoporotic-related fractures are among the leading causes of chronic disease morbidity in Europe and US. While a significant percentage can be repaired naturally, delayed-union non-union surgical intervention is necessary for proper bone regeneration. Given current lack optimized clinical techniques to adequately address this issue, tissue engineering (BTE) strategies focusing on development scaffolds temporarily replacing damaged supporting its regeneration process have been gaining interest. The piezoelectric properties bone, which an important role homeostasis regeneration, frequently neglected design BTE scaffolds. Therefore, study, we developed novel hydroxyapatite (HAp)-filled osteoinductive poly(vinylidene fluoride-co-tetrafluoroethylene) (PVDF-TrFE) nanofibers via electrospinning capable replicating tissue's fibrous extracellular matrix (ECM) composition native properties. PVDF-TrFE/HAp had biomimetic collagen fibril-like diameters, as well enhanced surface properties, translated into better capacity assist mineralization cell proliferation. biological cues provided by HAp nanoparticles osteogenic differentiation seeded human mesenchymal stem/stromal cells (MSCs) observed increased ALP activity, cell-secreted calcium deposition gene expression levels HAp-containing fibers. Overall, our findings describe potential combining PVDF-TrFE developing electroactive

Language: Английский

Citations

20

A review on external physical stimuli with biomaterials for bone repair DOI
T. David Luo, Bowen Tan, Jinfeng Liao

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 153749 - 153749

Published: July 4, 2024

Language: Английский

Citations

8

Direct coupled electrical stimulation towards improved osteogenic differentiation of human mesenchymal stem/stromal cells: a comparative study of different protocols DOI Creative Commons
João C. Silva, Jo�ão Meneses, Fábio F. F. Garrudo

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 5, 2024

Abstract Electrical stimulation (ES) has been described as a promising tool for bone tissue engineering, being known to promote vital cellular processes such cell proliferation, migration, and differentiation. Despite the high variability of applied protocol parameters, direct coupled electric fields have successfully osteogenic osteoinductive in vitro vivo. Our work aims study viability, differentiation human marrow-derived mesenchymal stem/stromal cells when subjected five different ES protocols. The protocols were specifically selected understand biological effects parts generated waveform typical direct-coupled stimuli. In culture studies evidenced variations responses with field magnitudes (numerically predicted) exposure protocols, mainly regarding mineralization (calcium contents) marker gene expression while maintaining viability regular morphology. Overall, our results highlight importance numerical guided experiments optimize parameters towards improved osteogenesis

Language: Английский

Citations

7