Local Administration of an Anti-Cancer Drug Using Tissue Adhesive Microparticles Based on Hydrophobically Modified Alaska Pollock Gelatin for Post-Surgical Cancer Chemotherapy

Published: Jan. 1, 2025

Language: Английский

Impact of hydrophobic modification on biocompatibility of Alaska pollock gelatin microparticles

Analytical Sciences, Journal Year: 2024, Volume and Issue: 40(11), P. 2053 - 2061

Published: Aug. 9, 2024

This study investigates the impact of hydrophobic modification on immunogenicity, cytotoxicity, and inflammatory response Alaska pollock gelatin (ApGltn) microparticles (MPs). Gelatin, known for its inherent biocompatibility, was modified with decyl group (C10) to explore potential alterations in interaction immune system. Immunogenicity evaluated through measurement material-specific IgM IgG responses, indicating no significant increase post-modification. Cytotoxicity against Caco-2 cell lines NF-κB-mediated LPS-induced inflammation were also assessed, revealing exacerbation by MPs. Furthermore, C10 different types linkage such as secondary amine amide structure did not influence reactivity. These findings suggest that maintains non-immunogenicity biocompatibility MPs, supporting their use biomedical applications.

Language: Английский

Development of a Janus tissue adhesive hemostatic patch based on hydrophobically-modified Alaska pollock gelatin

Biomaterials Advances, Journal Year: 2024, Volume and Issue: unknown, P. 214028 - 214028

Published: Sept. 1, 2024

Language: Английский