Optics Letters,
Journal Year:
2024,
Volume and Issue:
49(24), P. 7230 - 7230
Published: Dec. 2, 2024
Penicillin
G
detection
is
of
great
significance
in
medical
research
and
disease
diagnosis.
Liquid
crystal
(LC),
as
a
branch
sensitive
materials,
has
broad
application
prospect
the
field
biosensing.
Herein,
liquid
crystal-coated
silica
microbubble
resonator
(LC-MBR),
with
high
sensitivity
for
penicillin
detection,
been
proposed
demonstrated.
Whispering
gallery
mode
(WGM)
spectra
Q
factor
exceeding
10
6
were
excited
through
coupling
between
tapered
fiber
LC-MBR.
The
orientation
transition
LC
molecules,
combined
WGM
resonance,
amplified
target
information
triggered
wavelength
blueshifts.
LC-MBR
was
then
applied
pH
achieving
2.51
nm/pH
within
range
3.8–8.5.
This
also
successfully
employed
to
detect
enzymatic
reactions
penicillinase,
limit
×
3
U/mL.
fabricated
sensor
offers
significant
advantages,
including
simple
structure,
improved
stability,
higher
across
wide
range,
making
it
promising
candidate
future
biomedical
applications.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(14)
Published: April 1, 2025
Abstract
Diabetes
is
a
complex
metabolic
disorder
characterized
by
oxidative
stress
and
chronic
inflammation,
necessitating
the
development
of
multifunctional
therapeutic
agents.
This
study
evaluates
in
vitro
silico
antihyperglycemic,
antioxidant,
anti‐inflammatory
activities
four
3‐(4,5‐diaryl‐1
H
‐imidazol‐2‐yl)quinoline‐2‐amine
derivatives
(a–d)
.
Among
them,
compound
(a)
exhibited
strong
antihyperglycemic
activity,
with
significant
α‐amylase
inhibition
(IC
50
=
132.55
±
4.12
µg/mL)
enhanced
glucose
uptake
yeast
cells
126.32
3.48
µg/mL).
Compound
(d)
showed
superior
antioxidant
42–44
properties.
Molecular
docking
against
PPAR‐γ
confirmed
binding
interactions
for
all
compounds,
showing
collectively
better
affinity
(−10
kcal/mol
−11.1
kcal/mol).
Further,
molecular
dynamics
normal
mode
analysis
validated
its
stability
functional
potential.
The
ADMET
predictions
suggested
favorable
pharmacokinetics,
especially
compounds
(b)
findings
suggest
that
has
potential
as
lead
molecule
treatment
moderate
also
shows
promise,
albeit
slightly
lower
bioactivity.
Despite
these
promising
findings,
none
tested
outperformed
efficacy
standard
drugs
any
assays,
indicating
need
further
structural
optimization
to
enhance
their
Optics Letters,
Journal Year:
2024,
Volume and Issue:
49(24), P. 7230 - 7230
Published: Dec. 2, 2024
Penicillin
G
detection
is
of
great
significance
in
medical
research
and
disease
diagnosis.
Liquid
crystal
(LC),
as
a
branch
sensitive
materials,
has
broad
application
prospect
the
field
biosensing.
Herein,
liquid
crystal-coated
silica
microbubble
resonator
(LC-MBR),
with
high
sensitivity
for
penicillin
detection,
been
proposed
demonstrated.
Whispering
gallery
mode
(WGM)
spectra
Q
factor
exceeding
10
6
were
excited
through
coupling
between
tapered
fiber
LC-MBR.
The
orientation
transition
LC
molecules,
combined
WGM
resonance,
amplified
target
information
triggered
wavelength
blueshifts.
LC-MBR
was
then
applied
pH
achieving
2.51
nm/pH
within
range
3.8–8.5.
This
also
successfully
employed
to
detect
enzymatic
reactions
penicillinase,
limit
×
3
U/mL.
fabricated
sensor
offers
significant
advantages,
including
simple
structure,
improved
stability,
higher
across
wide
range,
making
it
promising
candidate
future
biomedical
applications.
