Biomimetic Piezoelectric Periosteum‐Bone Integrated Implant Promotes Bone Defect Repair by Remodeling Osteogenic Microenvironment

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Abstract Bone defects caused by trauma, infection, or tumors pose significant clinical challenges, particularly in large with poor healing outcomes. Traditional repair methods often fail to address the complex regenerative microenvironment. This study introduces a novel biomimetic piezoelectric periosteum‐bone bilayer implant designed remodel osteogenic microenvironment and enhance bone defect repair. The comprises an upper electrospun polyvinylidene fluoride‐curcumin‐loaded magnesium metal–organic framework (PVDF‐MOF/Cur, PMC) periosteum scaffold lower hydroxyapatite@gelatin methacrylate (HA@GelMA) (PMC+HA@GelMA, PMCG). In whole PMCG implant, PMC improves properties of PVDF enables sustained drug release via Mg‐MOF loaded Cur. Meanwhile, HA@GelMA facilitates marrow mesenchymal stem cells differentiation regeneration. Additionally, further accelerates promoting neuronal differentiation, as well enhancing angiogenesis regulating macrophage polarization. Transcriptome sequencing reveals that activates key signaling pathways associated angiogenesis, neurogenesis, inflammation regulation, osteogenesis, including HIF‐1α, PI3K‐Akt, JAK‐STAT, TGF‐β pathways. Thus, this work highlights multifunctional capabilities remodify accelerate repair, which offers promising platform for advancing tissue

Language: Английский

A Carbon Nanotube/Pyrrolidonecarboxylic Acid Zinc Sponge for programmed management of Diabetic Wounds: Hemostatic, Antibacterial, Anti-inflammatory, and Healing Properties

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101769 - 101769

Published: April 12, 2025

Wound healing in patients with diabetes is challenging because of chronic inflammation, inadequate vascularization, and susceptibility to infection. Current wound dressings often target specific stages lack comprehensive therapeutic approaches. This study introduces a novel approach using photodetachable sponge scaffold incorporating carbon nanotubes (CNTs), known for their high photothermal conversion efficiency, electrical conductivity, water absorption properties. The incorporated pyrrolidonecarboxylic acid zinc (PC1Z2), compound anti-inflammatory moisturizing properties, which was cross-linked within network CNTs decellularized dermal matrix. resulting shape-memory actively interfaces endogenous electric fields, facilitating signal transmission skin cells accelerating tissue repair. Upon exposure near-infrared (NIR) light, the PC1Z2 enhanced antibacterial efficacy (98 %) through conversion, promoting metabolism at site. Notably, absorbed exudates gradually released Zn2+, effectively reducing inflammation mice. In diabetic rat model, exudates, reduced accelerated granulation formation, angiogenesis, re-epithelialization. innovative dressing shows promise enhancing wounds.

Language: Английский

Collagen-rich porcine acellular dermal matrix-eggshell membrane sponge promotes programmed healing of diabetic wounds through the sustained release of Cu2+/Zn2+

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143545 - 143545

Published: April 26, 2025

Language: Английский