Electrochemically Deposited Polypyrrole–Glycine Coatings Incorporating Gentamicin on Magnesium Alloys: A Multifunctional Strategy for Enhanced Implant Durability and Biocompatibility DOI

M Nithishkumar,

Mohan Raj R,

Raj V

et al.

Published: May 9, 2025

Abstract Orthopedic surgeries are often complicated by infections like osteomyelitis, challenging treatment outcomes. Traditional methods, including systemic antibiotics and surgery, inadequate, leading to prolonged increased morbidity. Magnesium (Mg) its composites promising implant materials due their biodegradability compatibility with bone. However, rapid degradation in physiological conditions require corrosion-resistant surface modifications. Surface coatings, such as polymeric improve the mechanical biological properties of Mg-based implants. Additionally, drug delivery systems gentamicin-loaded coatings offer targeted infection control bone healing. This study explores formation magnesium oxide (MgO) on alloys through electrodeposition, followed electrochemical polymerization polypyrrole (PPy) glycine (Gly), subsequent loading gentamicin sulfate (GS) develop multifunctional coatings. Characterization AT-FTIR, XRD, FE-SEM, EDX confirms coatings' properties. These show excellent strength, corrosion resistance, antimicrobial effects, biocompatibility. In vitro, PPy-Gly-3-coated MgO promote osteoblast adhesion proliferation.

Language: Английский

Tannic Acid-Loaded Inorganic-Organic Coating on Magnesium Bone Nails for Enhanced Antibacterial, Anti-inflammatory and Corrosion Resistance DOI Creative Commons

Sirui Xu,

Chuanyao Dong,

Xiaolin Yu

et al.

Journal of Materials Research and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Biomimetic hydrogel periodontal membrane coating with mechanical compatibility for dental implant DOI

Yong Shao,

Tingting Kong, Yujun Zhang

et al.

Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 105959 - 105959

Published: Feb. 1, 2025

Language: Английский

Citations

0
Enhanced corrosion resistance of magnesium alloy via surface transfer of microwave-synthesized, non-toxic, and ultra-smooth nitrogen-doped amorphous carbon thin film DOI Creative Commons

Adarsh Rai,

Mateusz Szczerba, Joanna Karbowniczek

et al.

Applied Surface Science, Journal Year: 2025, Volume and Issue: unknown, P. 162847 - 162847

Published: March 1, 2025

Language: Английский

Citations

0
Biological and antibacterial evaluation of Ag-loaded chitosan-coated TiO2 nanotubular surface on Ti6Al4V implants DOI
Konduru Ashok Kumar Raju, Amit Biswas

Journal of Industrial and Engineering Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Decoupling of Density-Dependent Migration/Proliferation Dichotomy on Surface Potential Gradient DOI
Zejun Chen, Lingqing Dong

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

The reciprocal connection between cell migration and proliferation relies on the intertwined contributions from substrate-associated intercellular cues in microenvironment. However, how cells perceive substrates, make contact with their neighbors, switch phenotypes under different trade-off conditions are still not fully understood. Here, we designed a distinct heterogeneous electric surface potential gradient of piezoelectric biomaterials to decouple density-dependent migration/proliferation dichotomy. We found that accelerated both individual collective but reduced through G0/G1 cycle arrest via integrin/cytoskeleton signaling axis low density. Interestingly, initial density encodes proliferative independent substrate feature. While high density, ceased mainly E-cadherin/β-catenin axis. Taken together, these results shed light underlying mechanism cell-material cell-cell cross-links also provide new paradigm materiobiology.

Language: Английский

Citations

0
Electrochemically Deposited Polypyrrole–Glycine Coatings Incorporating Gentamicin on Magnesium Alloys: A Multifunctional Strategy for Enhanced Implant Durability and Biocompatibility DOI

M Nithishkumar,

Mohan Raj R,

Raj V

et al.

Published: May 9, 2025

Abstract Orthopedic surgeries are often complicated by infections like osteomyelitis, challenging treatment outcomes. Traditional methods, including systemic antibiotics and surgery, inadequate, leading to prolonged increased morbidity. Magnesium (Mg) its composites promising implant materials due their biodegradability compatibility with bone. However, rapid degradation in physiological conditions require corrosion-resistant surface modifications. Surface coatings, such as polymeric improve the mechanical biological properties of Mg-based implants. Additionally, drug delivery systems gentamicin-loaded coatings offer targeted infection control bone healing. This study explores formation magnesium oxide (MgO) on alloys through electrodeposition, followed electrochemical polymerization polypyrrole (PPy) glycine (Gly), subsequent loading gentamicin sulfate (GS) develop multifunctional coatings. Characterization AT-FTIR, XRD, FE-SEM, EDX confirms coatings' properties. These show excellent strength, corrosion resistance, antimicrobial effects, biocompatibility. In vitro, PPy-Gly-3-coated MgO promote osteoblast adhesion proliferation.

Language: Английский

Citations

0