Cell Communication and Signaling,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: April 18, 2025
The
canonical
functions
of
vimentin
in
cell
mechanics
and
migration
have
been
recently
expanded
by
the
discovery
new
roles
for
extracellular
(ECV)
immune
responses
to
infection,
injury
cancer.
In
contrast
with
predominantly
filamentous
form
intracellular
vimentin,
ECV
exists
largely
as
soluble
oligomers.
release
from
intact
cells
is
dependent
on
mechanisms
that
regulate
assembly
disassembly
which
are
influenced
discrete
post-translational
modifications.
this
review
we
highlight
processes
promote
conversion
insoluble
filaments
secretion
mechanisms.
Insights
into
regulation
stromal
could
provide
diagnostic
therapeutic
approaches
assessing
controlling
inflammatory
diseases.
Journal of Personalized Medicine,
Journal Year:
2025,
Volume and Issue:
15(4), P. 135 - 135
Published: March 31, 2025
Background:
Traumatic
brain
injury
(TBI)
is
one
of
the
main
causes
death
in
trauma
pathology,
especially
among
youngest
victims.
After
having
evaluated
causality
relationship
between
damage
to
tissue
and
death,
pathologists
should
try
estimate
duration
TBI
death.
Immunohistochemistry
could
be
used
this
field
as
a
personalized
medico-legal
approach.
This
study
aims
evaluate
possible
role
vimentin
p53
markers
assess
vitality
date
TBI.
Methods:
Twelve
cases
deaths
were
selected
(two
women
ten
men,
with
mean
age
46.83
years).
In
seven
cases,
occurred
immediately
after
trauma,
while
others,
some
days.
An
immunohistological
samples
using
anti-p53
anti-vimentin
antibodies
was
performed.
A
semi-quantitative
scale
adopted
grade
immunohistochemical
reaction.
Results:
Our
results
showed
strong
immunoreaction
(X-squared
value
10.971,
p-value
<
0.01),
suggesting
that
expression
enhanced
cases.
Vimentin
more
expressed
when
PTI
longer.
Vimentin-immunoreaction
weaker
than
p53-immunoreaction
(+0.75
vs.
+1.83
values,
respectively)
group
predominantly
including
short
post-traumatic
interval
Conclusions:
The
present
research
limited
by
small
sample
size;
however,
molecules
tested,
p53,
have
shown
great
potential
used,
addition
biological
for
diagnosis
timing
Cell Communication and Signaling,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: April 18, 2025
The
canonical
functions
of
vimentin
in
cell
mechanics
and
migration
have
been
recently
expanded
by
the
discovery
new
roles
for
extracellular
(ECV)
immune
responses
to
infection,
injury
cancer.
In
contrast
with
predominantly
filamentous
form
intracellular
vimentin,
ECV
exists
largely
as
soluble
oligomers.
release
from
intact
cells
is
dependent
on
mechanisms
that
regulate
assembly
disassembly
which
are
influenced
discrete
post-translational
modifications.
this
review
we
highlight
processes
promote
conversion
insoluble
filaments
secretion
mechanisms.
Insights
into
regulation
stromal
could
provide
diagnostic
therapeutic
approaches
assessing
controlling
inflammatory
diseases.
