Iron oxide nanoparticles: The versatility of the magnetic and functionalized nanomaterials in targeting drugs, and gene deliveries with effectual magnetofection

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105838 - 105838

Published: June 3, 2024

Language: Английский

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Application of 3D, 4D, 5D, and 6D bioprinting in cancer research: what does the future look like?

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(19), P. 4584 - 4612

Published: Jan. 1, 2024

Recent advancements pertaining to the application of 3D, 4D, 5D, and 6D bioprinting in cancer research are discussed, focusing on important challenges future perspectives.

Language: Английский

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Label-Free and Rapid Microfluidic Design Rules for Circulating Tumor Cell Enrichment and Isolation: A Review and Simulation Analysis

ACS Omega, Journal Year: 2025, Volume and Issue: 10(7), P. 6306 - 6322

Published: Feb. 11, 2025

Enriching and isolating circulating tumor cells (CTCs) have attracted significant interest due to their important role in early cancer diagnosis prognosis, allowing for minimally invasive approaches providing vital information about metastasis at the cellular level. This review comprehensively summarizes recent developments microfluidic devices CTC enrichment isolation. The advantages limitations of several are discussed, design specifications highlighted. We also developed a set methodologies rules label-free microfluidics such as spiral, deterministic lateral displacement (DLD) dielectrophoresis (DEP) allow researchers develop systematically effectively, promoting rapid research on design, fabrication, experimentation.

Language: Английский

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Modeling the dynamics of circulating tumor cell clusters inside a microfluidic channel

Biomicrofluidics, Journal Year: 2025, Volume and Issue: 19(1)

Published: Jan. 1, 2025

Circulating tumor cells are central to metastasis, a particularly malign spread of cancer beyond its original location. While rare, there is growing evidence that the clusters circulating significantly more harmful than individual cells. Microfluidic platforms constitute core cell cluster research, allowing detection, analysis, and treatment. In this work, we propose new mathematical model apply it simulate dynamics aggregates inside microfluidic channel with external flow fluid. We leverage our previous interactions varying clustering affinities introduce explicit bonds between makeup cluster. show have visible impact on they enable reproduction known deformation patterns. Furthermore, demonstrate these sensitive bond properties, as well initialization conditions. believe modeling framework represents valuable mesoscopic formulation an clusters, common in both nature applications.

Language: Английский

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Microfluidic Device for Both Active and Passive Cell Separation Techniques: A Review

Sensors and Actuators Reports, Journal Year: 2024, Volume and Issue: unknown, P. 100277 - 100277

Published: Dec. 1, 2024

Language: Английский

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Advances in nanobubbles for cancer theranostics: Delivery, imaging and therapy

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 226, P. 116341 - 116341

Published: June 5, 2024

Language: Английский

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