From defense to offense: antimicrobial peptides as promising therapeutics for cancer DOI Creative Commons
Hadi Zare‐Zardini, Elham Saberian, Andrej Jenča

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Oct. 9, 2024

Antimicrobial peptides (AMPs), naturally occurring components of innate immunity, are emerging as a promising new class anticancer agents. This review explores the potential AMPs novel AMPs, with broad-spectrum antimicrobial activity, exhibit several characteristics that make them attractive candidates for cancer therapy, including selectivity cells, and immunomodulatory effects. Analysis dataset activity reveals their effectiveness is influenced by various structural properties, net charge, length, Boman index, hydrophobicity. These properties contribute to ability target disrupt cell membranes, interfere intracellular processes, modulate immune response. The highlights frontier in treatment, offering hope more effective less toxic therapies. demonstrate therapy through multiple mechanisms, direct cytotoxicity, response modulation, targeting tumor microenvironment, evidenced extensive preclinical studies animal models showing regression, metastasis inhibition, improved survival rates. show significant therapeutics microenvironment targeting, results from early-phase clinical trials. Future research should focus on optimizing AMP developing delivery strategies, exploring synergistic combination therapies fully realize treatments, while addressing challenges related stability, delivery, toxicity.

Language: Английский

From defense to offense: antimicrobial peptides as promising therapeutics for cancer DOI Creative Commons
Hadi Zare‐Zardini, Elham Saberian, Andrej Jenča

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Oct. 9, 2024

Antimicrobial peptides (AMPs), naturally occurring components of innate immunity, are emerging as a promising new class anticancer agents. This review explores the potential AMPs novel AMPs, with broad-spectrum antimicrobial activity, exhibit several characteristics that make them attractive candidates for cancer therapy, including selectivity cells, and immunomodulatory effects. Analysis dataset activity reveals their effectiveness is influenced by various structural properties, net charge, length, Boman index, hydrophobicity. These properties contribute to ability target disrupt cell membranes, interfere intracellular processes, modulate immune response. The highlights frontier in treatment, offering hope more effective less toxic therapies. demonstrate therapy through multiple mechanisms, direct cytotoxicity, response modulation, targeting tumor microenvironment, evidenced extensive preclinical studies animal models showing regression, metastasis inhibition, improved survival rates. show significant therapeutics microenvironment targeting, results from early-phase clinical trials. Future research should focus on optimizing AMP developing delivery strategies, exploring synergistic combination therapies fully realize treatments, while addressing challenges related stability, delivery, toxicity.

Language: Английский

Citations

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