Tools to Dissect Lipid Droplet Regulation, Players, and Mechanisms

ACS Chemical Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Spurred by the authors' own recent discovery of reactive metabolite-regulated nexuses involving lipid droplets (LDs), this perspective discusses latest knowledge and multifaceted approaches toward deconstructing function these dynamic organelles, LD-associated localized signaling networks, protein players. Despite accumulating surrounding families pathways conserved importance for LD homeostasis surveillance maintenance across taxa, much remains to be understood at molecular level. In particular, metabolic stress-triggered contextual changes in LD-proteins' functions, crosstalk with other feedback loops how are specifically rewired disease states remain illuminated spatiotemporal precision. We hope promotes an increased interest essential organelles innovations new tools strategies better understand context-specific regulation critical organismal health.

Language: Английский

Microalgal Neutral Lipid Accumulation: Cellular Mechanism and Ways to Improve Biodiesel Production

BioEnergy Research, Journal Year: 2025, Volume and Issue: 18(1)

Published: May 27, 2025

Language: Английский

Lipids, from molecular mechanisms to diseases

Biochimie, Journal Year: 2024, Volume and Issue: 227, P. 1 - 2

Published: Nov. 12, 2024

Language: Английский