Obesity, White Adipose Tissue, and Adipokines Signaling in Male Reproduction

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

ABSTRACT Currently, obesity is a global pandemic characterized by systemic metabolic complications that negatively impact several organs, including white adipose tissue (WAT) and the tissues of male reproductive system. Since discovery leptin in 1994, WAT has been recognized as dynamic endocrine organ for secreting series molecules with hormonal functions, collectively called adipokines. The link between obesity, WAT, adipokines, system direct little explored. With changes nutritional status, undergoes morphofunctional changes, secretion adipokines altered, impacting mechanisms, steroidogenesis spermatogenesis. In this review, we address an updated way structural functional characteristics well signaling pathways leptin, adiponectin, resistin, visfatin, apelin, chemerin, omentin‐1, vaspin, asprosin reproduction. Understanding relationship these dysfunction can contribute to new strategies treatment subfertility infertility.

Language: Английский

Metabolic and molecular basis of flavonoid biosynthesis in Lycii fructus: an integration of metabolomic and transcriptomic analysis

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2024, Volume and Issue: 255, P. 116653 - 116653

Published: Dec. 25, 2024

Language: Английский