Antibacterial performance of Co–Zn ferrite nanoparticles under visible light irradiation DOI Creative Commons

Alicia G. Gubieda,

Ana Abad, Ana García‐Prieto

et al.

Journal of Chemical Technology & Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract BACKGROUND To address water scarcity and promote sustainable resource management, more efficient cost‐effective treatment solutions are necessary. Particularly, pathogens in drinking a topic of growing concern. One promising technology is the use photocatalytic nanoparticles activated by visible light as antibacterial agents. This study focuses on characterization properties Co–Zn ferrite nanocatalysts, tested against Escherichia coli . RESULTS The Co x Zn 1− Fe 2 O 4 ( = 0, 0.1, 0.4 0.6) ferrites were synthesized co‐precipitation method. Structural, morphological optical analyses confirmed that these have cubic spinel structure, with sizes around 10 nm, band gap energies suitable for activation (1.4–1.7 eV). efficacy E. was compared their performance employing phenol organic pollutant model (highest degradation 0.6). Specifically, capacity evaluated comparing ability bacteria to grow after being incubated under dark. It found lower cobalt content 0 0.1) significantly reduced bacterial culturability light. Transmission Electron Microscopy analysis revealed caused secrete biofilm, potentially offering some protection nanoparticles. CONCLUSION ZnFe show highest effect amongst those tested. attributed combined action 2+ ion release Furthermore, might inhibit protective biofilm secretion, leading higher effects. © 2024 Author(s). Journal Chemical Technology Biotechnology published John Wiley & Sons Ltd behalf Society Industry (SCI).

Language: Английский

Nanoparticles in the battle against Candida auris biofilms: current advances and future prospects DOI Creative Commons
Bahgat Fayed

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Candida auris has emerged as a significant global health threat due to its multidrug resistance and ability form robust biofilms, particularly on medical devices hospital surfaces. Biofilms protect C. from antifungal treatments the host immune response, making infections persistent difficult control. This review explores potential of nanoparticles overcome limitations traditional therapies in combating biofilms. Nanoparticles, with their unique physicochemical properties, offer promising strategies penetrate biofilm matrices, deliver agents, disrupt structure. Various types nanoparticles, including metallic, polymeric, lipid-based, cyclodextrin-based, demonstrate enhanced penetration activity. Their generate reactive oxygen species, cell adhesion, release antifungals controlled manner makes them ideal candidates for biofilm-targeted therapies. presents current advancements nanoparticle-based solutions, emphasizing need further research into mechanisms action, safety, clinical application. By addressing challenge biofilms specifically, this provides critical synthesis existing knowledge identifies future directions developing effective using nanotechnology. Graphical abstract

Language: Английский

Citations

1
Biofilm-Based Immobilization Fermentation for Continuous hEGF Production in Saccharomyces cerevisiae DOI Creative Commons

Kaiqi Zhi,

Zhiguo An,

Mingyang Zhang

et al.

Fermentation, Journal Year: 2024, Volume and Issue: 10(12), P. 661 - 661

Published: Dec. 21, 2024

Biofilms can enhance industrial fermentation efficiency by increasing cell density, stability, and metabolic activity have been successfully applied to the continuous production of many small-molecule chemicals. However, proteins biofilms has less studied. This study used secretory human epidermal growth factor (hEGF) as a representative product evaluate optimize biofilm-based protein production. First, deleting protease overexpressing eight key genes involved in secretion Saccharomyces cerevisiae, yield hEGF was improved 82.6% from 77.4 141.3 mg/L shake flasks. Subsequently, flocculation FLO11 ALS3 were introduced facilitate establishment immobilization model. The optimal strain SIC-ALS3-PDI1 produced 583.8 hEGF, with productivity 4.9 mg/L/h during traditional free-cell fermentation, while it an average 300.0 10 batches 6.3 mg/L/h. Although lower than that biofilm demonstrated greater productivity, advantage not requiring seed culture for each batch fermentation. provided valuable reference other peptides.

Language: Английский

Citations

1
The CpxAR signaling system confers a fitness advantage for flea gut colonization by the plague bacillus DOI
Brandon Robin,

Amélie Dewitte,

Véronique Alaimo

et al.

Journal of Bacteriology, Journal Year: 2024, Volume and Issue: 206(9)

Published: Aug. 19, 2024

ABSTRACT The adaptation of Yersinia pestis , the flea-borne plague agent, to fluctuating environmental conditions is essential for successful colonization flea vector. A previous comparative transcriptomic analysis showed that Cpx pathway Y. up-regulated in infected fleas. CpxAR two-component system a component envelope stress response and critical maintaining integrity cell. Here, phenotypic screening revealed survival defect cpxAR mutant oxidative copper. measured copper concentration digestive tract contents fed fleas increased fourfold during process. By direct phosphorylation CpxR by Phos-Tag gel approach, we demonstrated biologically relevant concentrations triggered system. Then, competitive challenge highlighted role bacterial fitness infection. Lastly, an vitro sequential exposure then H 2 O mimic suggests model which, within insect tract, would be copper, establishing response. IMPORTANCE bacterium agent plague. Our knowledge mechanisms used bacillus infect vector limited. up-regulation under control signaling was previously shown study. our vivo approaches suggest which uses phosphorelay sense respond present gut, thereby optimizing gut colonization. In other words, flea.

Language: Английский

Citations

0
Combinatorial Effects of Ursodeoxycholic Acid and Antibiotic in Combating Staphylococcus aureus Biofilm: The Roles of ROS and Virulence Factors DOI Creative Commons
Anuradha Tyagi, Vinay Kumar, Navneet Joshi

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(10), P. 1956 - 1956

Published: Sept. 27, 2024

is a biofilm-forming bacterium responsible for various human infections, one particularly challenging to treat due its antibiotic resistance. Biofilms can form on both soft tissues and medical devices, leading persistent hard-to-treat infections. Combining multiple antimicrobials potential approach overcoming this This study explored the effects of ursodeoxycholic acid (UDCA) combined with ciprofloxacin against

Language: Английский

Citations

0
Neutrophil-Inspired Zn and Zn@ZnO Microparticles Decorated with Cu Nanoparticles Self-Release Oxidized Halogen Antimicrobials DOI
Guangshun Yi, Siew Ping Teong, Shujun Gao

et al.

Materials Today Nano, Journal Year: 2024, Volume and Issue: 28, P. 100542 - 100542

Published: Nov. 16, 2024

Language: Английский

Citations

0
Antibacterial performance of Co–Zn ferrite nanoparticles under visible light irradiation DOI Creative Commons

Alicia G. Gubieda,

Ana Abad, Ana García‐Prieto

et al.

Journal of Chemical Technology & Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract BACKGROUND To address water scarcity and promote sustainable resource management, more efficient cost‐effective treatment solutions are necessary. Particularly, pathogens in drinking a topic of growing concern. One promising technology is the use photocatalytic nanoparticles activated by visible light as antibacterial agents. This study focuses on characterization properties Co–Zn ferrite nanocatalysts, tested against Escherichia coli . RESULTS The Co x Zn 1− Fe 2 O 4 ( = 0, 0.1, 0.4 0.6) ferrites were synthesized co‐precipitation method. Structural, morphological optical analyses confirmed that these have cubic spinel structure, with sizes around 10 nm, band gap energies suitable for activation (1.4–1.7 eV). efficacy E. was compared their performance employing phenol organic pollutant model (highest degradation 0.6). Specifically, capacity evaluated comparing ability bacteria to grow after being incubated under dark. It found lower cobalt content 0 0.1) significantly reduced bacterial culturability light. Transmission Electron Microscopy analysis revealed caused secrete biofilm, potentially offering some protection nanoparticles. CONCLUSION ZnFe show highest effect amongst those tested. attributed combined action 2+ ion release Furthermore, might inhibit protective biofilm secretion, leading higher effects. © 2024 Author(s). Journal Chemical Technology Biotechnology published John Wiley & Sons Ltd behalf Society Industry (SCI).

Language: Английский

Citations

0