Emerging Role of Gut Microbiota in Breast Cancer Development and Its Implications in Treatment DOI Creative Commons
Rashid Mir,

Shrooq A. Albarqi,

Wed Albalawi

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(12), P. 683 - 683

Published: Dec. 5, 2024

Background: The human digestive system contains approximately 100 trillion bacteria. gut microbiota is an emerging field of research that associated with specific biological processes in many diseases, including cardiovascular disease, obesity, diabetes, brain rheumatoid arthritis, and cancer. Emerging evidence indicates the affects response to anticancer therapies by modulating host immune system. Recent studies have explained a high correlation between breast cancer: dysbiosis cancer may regulate systemic inflammatory response, hormone metabolism, tumor microenvironment. Some bacteria are related estrogen which increase or decrease risk changing number hormones. Further, has been seen modulate respect its ability protect against treat cancers, focus on receptor-positive Probiotics other claiming control microbiome bacterial means might be useful prevention, even treatment, Conclusions: present review underlines various aspects clinical application, warranting individualized microbiome-modulated therapeutic approaches treatment.

Language: Английский

Seseli foliosum (Somm. et Levier) Manden.—A Comprehensive Phytochemical and Biological Evaluation DOI Creative Commons
Mariam Nersezashvili, Dali Berashvili,

Malkhaz Jokhadze

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 725 - 725

Published: Feb. 5, 2025

The genus Seseli L. (Apiaceae family) is widespread across Europe and Asia, with ten species identified in Georgia. Among these, foliosum (Somm. et Levier) Manden., notable for its unique pharmacological properties. To our knowledge, comprehensive phytochemical biological investigations have not yet been conducted. primary aim of this research to explore the chemical properties S. foliosum, thereby enhancing potential applications medicine related fields. Different chromatographic techniques were utilized isolate individual compounds identify composition MeOH Et2O extracts from seeds roots. A battery assays (antimicrobial, antioxidant, enzymatic, anxiolytic, cytotoxic) employed assess extracts. results gas chromatography mass spectrometry (GC/MS) revealed that both contain a diverse array compounds, including monoterpenoids, sesquiterpenoids, phenolic compounds. Furanocoumarin edultin was isolated extract by liquid–liquid separation (LLS). exhibited important enzyme inhibitory, antimicrobial activities efficacy against Staphylococcus aureus (MIC 125 µg/mL) Candida glabrata 62.5 µg/mL). Underground showed advanced cytotoxic activity, particularly hypopharyngeal carcinoma cells (CC50 22.33 µg/mL 27.16 µg/mL, respectively). study provides wide-range analysis highlighting as source bioactive These findings contribute understanding therapeutic lay groundwork further clinical research.

Language: Английский

Citations

0
Decoding the Tumor-Associated Microbiota: From Origins to Nanomedicine Applications in Cancer Therapy DOI Creative Commons

Ruiqi Wang,

Weizheng Li, Hongqian Cao

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(3), P. 243 - 243

Published: Feb. 27, 2025

Growing evidence reveals that the tumor microbiome—comprising distinct microbial communities within neoplastic tissues—exerts a profound influence on cancer initiation, progression, and therapeutic response. These microbes actively reshape microenvironment (TME) through metabolite secretion, modulation of immune pathways, direct interactions with host cells, thereby affecting biology outcomes. Despite substantial heterogeneity among types, recent insights underscore microbiome’s potential as both diagnostic/prognostic biomarker targetable component for innovative treatments. In this review, we synthesize emerging knowledge mechanistic roles tumor-associated microbiota in shaping TME, focus how these discoveries can guide novel strategies. We further explore interdisciplinary advances, including convergence microbiomics nanotechnology, to enhance drug delivery, circumvent resistance, foster TME remodeling. By highlighting cutting-edge developments, our review underscores transformative integrating microbiome research into precision oncology advancing more personalized therapies.

Language: Английский

Citations

0
Isolation, Screening, and Identification of Staphylococcus epidermidis with Effective Probiotic Attributes DOI
Sonia Sharma, Md. Nazim Uddin, Gurleen Kaur Sodhi

et al.

Current Microbiology, Journal Year: 2025, Volume and Issue: 82(6)

Published: April 7, 2025

Language: Английский

Citations

0
Emerging Role of Gut Microbiota in Breast Cancer Development and Its Implications in Treatment DOI Creative Commons
Rashid Mir,

Shrooq A. Albarqi,

Wed Albalawi

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(12), P. 683 - 683

Published: Dec. 5, 2024

Background: The human digestive system contains approximately 100 trillion bacteria. gut microbiota is an emerging field of research that associated with specific biological processes in many diseases, including cardiovascular disease, obesity, diabetes, brain rheumatoid arthritis, and cancer. Emerging evidence indicates the affects response to anticancer therapies by modulating host immune system. Recent studies have explained a high correlation between breast cancer: dysbiosis cancer may regulate systemic inflammatory response, hormone metabolism, tumor microenvironment. Some bacteria are related estrogen which increase or decrease risk changing number hormones. Further, has been seen modulate respect its ability protect against treat cancers, focus on receptor-positive Probiotics other claiming control microbiome bacterial means might be useful prevention, even treatment, Conclusions: present review underlines various aspects clinical application, warranting individualized microbiome-modulated therapeutic approaches treatment.

Language: Английский

Citations

2