ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(18), P. 11964 - 11977
Published: April 24, 2024
In
view
of
the
depletion
natural
energy
resources,
harvesting
from
waste
is
a
revolution
to
simultaneously
capture,
unite,
and
recycle
various
types
energies
in
flexible
devices.
Thus,
this
work,
spin-charge-regulated
pyro-magneto-electric
nanogenerator
devised
at
well-known
ferroelectric
P(VDF-TrFE)
copolymer.
It
promptly
stores
thermal-magnetic
"capacitor"
that
generates
electricity
room
temperature.
The
domains
are
regulated
slip
interfaces
(also
twins)
duly
promoting
polarization
other
properties.
An
excellent
pyroelectric
coefficient
p
∼
615
nC·m–2·K–1
obtained,
with
enhanced
stimuli
thermal
sensitivity
∼1.05
V·K–1,
magnetoelectric
αme
∼8.8
mV·cm–1·Oe–1
180
Hz
(resonance
frequency),
magnetosensitivity
∼473
V/T.
noteworthy
strategy
further
improving
(up
41.2
μC·m–2·K–1)
23.6
mV·cm–1·Oe–1)
realized
electrically
poled
dipoles.
model
hybrid
structure,
spins
lead
switch
up
electric
dipoles
parallel
polymer
chains
cohesive
charged
layer.
an
innovative
approach
for
efficiently
scavenging
vehicles,
homes,
industries,
where
abundant
magnetic
accessible.
This
sustainable
could
be
useful
next-generation
self-powered
electronics.
Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
32(27)
Published: March 16, 2022
Abstract
Bone
repair
in
patients
with
osteoporosis
remains
a
big
challenge
because
their
injury
sites
are
often
accompanied
by
an
abnormal
level
of
inflammation
and
reactive
oxygen
species
(ROS).
ROS
is
previously
visualized,
represented
hydrogen
peroxide
(H
2
O
),
the
bone
defects.
In
this
study,
H
animals
further
it
found
that
expression
markedly
higher
than
normal
animals.
Subsequently,
composite
hydrogel
containing
manganese
dioxide
(MnO
)‐coated
calcium
phosphate
microspheres
loaded
fibroblast
activating
protein
inhibitor
(FAPi)
prepared.
Among
them,
MnO
designed
to
act
as
advanced
army
eliminate
generate
oxygen,
constant
release
FAPi
used
regulate
immune
response
formation.
vitro
experiments
show
hydrogels
effectively
reduce
intracellular
ROS,
guide
macrophages
toward
M2
polarization,
alleviate
inflammation.
Furthermore,
enhance
osteogenesis
inhibit
osteoclastogenesis.
Animal
demonstrate
can
macrophages,
promote
osteoporotic
Together,
findings
from
study
imply
multi‐pronged
approach
holds
great
promise
defects
rescuing
microenvironment
guiding
response.
Small,
Journal Year:
2023,
Volume and Issue:
19(28)
Published: May 16, 2023
Abstract
A
photoactivated
bone
scaffold
integrated
with
minimally
invasive
implantation
and
mild
thermal‐stimulation
capability
shows
great
promise
in
the
repair
regeneration
of
irregularly
damaged
tissues.
Developing
multifunctional
photothermal
biomaterials
that
can
simultaneously
serve
as
both
controllable
thermal
stimulators
biodegradable
engineering
scaffolds
for
immunomodulation,
infection
therapy,
impaired
remains
an
enormous
challenge.
Herein,
injectable
photocurable
hydrogel
therapeutic
platform
(AMAD/MP)
based
on
alginate
methacrylate,
alginate‐graft‐dopamine,
polydopamine
(PDA)‐functionalized
Ti3C2
MXene
(MXene@PDA)
nanosheets
is
rationally
designed
near‐infrared
(NIR)‐mediated
synergistic
osteogenesis,
bacterial
elimination.
The
optimized
AMAD/MP
exhibits
favorable
biocompatibility,
osteogenic
activity,
immunomodulatory
functions
vitro.
proper
immune
microenvironment
provided
by
could
further
modulate
balance
M1/M2
phenotypes
macrophages,
thereby
suppressing
reactive
oxygen
species‐induced
inflammatory
status.
Significantly,
this
stimulation
efficiently
attenuates
local
reactions
promotes
new
formation
without
addition
exogenous
cells,
cytokines,
or
growth
factors.
This
work
highlights
potential
application
advanced
providing
on‐demand
cues
tissue
regenerative
medicine.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: July 10, 2023
Abstract
For
bone
defect
repair
under
co-morbidity
conditions,
the
use
of
biomaterials
that
can
be
non-invasively
regulated
is
highly
desirable
to
avoid
further
complications
and
promote
osteogenesis.
However,
it
remains
a
formidable
challenge
in
clinical
applications
achieve
efficient
osteogenesis
with
stimuli-responsive
materials.
Here,
we
develop
polarized
CoFe
2
O
4
@BaTiO
3
/poly(vinylidene
fluoridetrifluoroethylene)
[P(VDF-TrFE)]
core-shell
particle-incorporated
composite
membranes
high
magnetoelectric
conversion
efficiency
for
activating
regeneration.
An
external
magnetic
field
force
conduct
on
core
increase
charge
density
BaTiO
shell
strengthens
β-phase
transition
P(VDF-TrFE)
matrix.
This
energy
increases
membrane
surface
potential,
which
hence
activates
Skull
experiments
male
rats
showed
repeated
enhanced
repair,
even
when
repression
elicited
by
dexamethasone
or
lipopolysaccharide-induced
inflammation.
study
provides
strategy
utilizing
efficiently
activate
situ.
The
critical
factor
determining
the
in
vivo
effect
of
bone
repair
materials
is
microenvironment,
which
greatly
depends
on
their
abilities
to
promote
vascularization
and
formation.
However,
implant
are
far
from
ideal
candidates
for
guiding
regeneration
due
deficient
angiogenic
osteogenic
microenvironments.
Herein,
a
double-network
composite
hydrogel
combining
vascular
endothelial
growth
(VEGF)-mimetic
peptide
with
hydroxyapatite
(HA)
precursor
was
developed
build
an
microenvironment
repair.
prepared
by
mixing
acrylated
β-cyclodextrins
octacalcium
phosphate
(OCP),
HA
precursor,
gelatin
solution,
followed
ultraviolet
photo-crosslinking.
To
improve
potential
hydrogel,
QK,
VEGF-mimicking
peptide,
loaded
β-cyclodextrins.
QK-loaded
promoted
tube
formation
human
umbilical
vein
cells
upregulated
expression
angiogenesis-related
genes,
such
as
Flt1,
Kdr,
VEGF,
marrow
mesenchymal
stem
cells.
Moreover,
QK
could
recruit
Furthermore,
OCP
be
transformed
into
release
calcium
ions
facilitating
regeneration.
integrated
showed
obvious
osteoinductive
activity.
results
animal
experiments
that
enhanced
skull
defects
rats,
perfect
synergistic
effects
vascularized
In
summary,
improving
microenvironments
our
shows
promising
prospects
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(17), P. 16573 - 16586
Published: Aug. 14, 2023
An
essential
challenge
in
diabetic
periodontal
regeneration
is
achieving
the
transition
from
a
hyperglycemic
inflammatory
microenvironment
to
regenerative
one.
Here,
we
describe
polydopamine
(PDA)-mediated
ultralong
silk
microfiber
(PDA-mSF)
and
metformin
(Met)-loaded
zeolitic
imidazolate
framework
(ZIF)
incorporated
into
fibroin/gelatin
(SG)
patch
promote
soft
hard
tissue
by
regulating
immunomodulatory
microenvironment.
The
PDA-mSF
endows
with
reactive
oxygen
species
(ROS)-scavenging
ability
anti-inflammatory
activity,
reducing
response
suppressing
M1
macrophage
polarization.
Moreover,
PDA
improves
ligament
reconstruction
via
its
cell
affinity.
Sustained
release
of
Met
Met-ZIF
system
confers
antiaging
abilities
activating
M2
polarization
secrete
osteogenesis-related
cytokines,
while
Zn2+
also
promotes
bone
regeneration.
Consequently,
creates
favorable
for
These
features
synergistically
accelerate
Thus,
our
findings
offer
potential
therapeutic
strategy
periodontitis.
Bone Research,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: May 14, 2024
Osteomyelitis
is
a
devastating
disease
caused
by
microbial
infection
in
deep
bone
tissue.
Its
high
recurrence
rate
and
impaired
restoration
of
deficiencies
are
major
challenges
treatment.
Microbes
have
evolved
numerous
mechanisms
to
effectively
evade
host
intrinsic
adaptive
immune
attacks
persistently
localize
the
host,
such
as
drug-resistant
bacteria,
biofilms,
persister
cells,
intracellular
small
colony
variants
(SCVs).
Moreover,
microbial-mediated
dysregulation
microenvironment
impedes
regeneration
process,
leading
defect
repair.
Despite
advances
surgical
strategies
drug
applications
for
treatment
infections
within
last
decade,
remain
clinical
management.
The
development
application
tissue
engineering
materials
provided
new
infections,
but
comprehensive
review
their
research
progress
lacking.
This
discusses
critical
pathogenic
microbes
skeletal
system
immunomodulatory
effects
on
regeneration,
highlights
prospects
technologies
infections.
It
will
inform
translation
antimicrobial
repair
management
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
38, P. 346 - 373
Published: May 9, 2024
Gelatin
methacryloyl
(GelMA)
hydrogels
is
a
widely
used
bioink
because
of
its
good
biological
properties
and
tunable
physicochemical
properties,
which
has
been
in
variety
tissue
engineering
regeneration.
However,
pure
GelMA
limited
by
the
weak
mechanical
strength
lack
continuous
osteogenic
induction
environment,
difficult
to
meet
needs
bone
repair.
Moreover,
are
unable
respond
complex
stimuli
therefore
adapt
physiological
pathological
microenvironments.
This
review
focused
on
functionalization
strategies
hydrogel
based
bioinks
for
The
synthesis
process
was
described
details,
various
functional
methods
requirements
regeneration,
including
strength,
porosity,
vascularization,
differentiation,
immunoregulation
patient
specific
repair,
etc.
In
addition,
response
smart
GelMA-based
external
physical
stimulation
internal
microenvironment
stimulation,
as
well
achieve
both
disease
treatment
regeneration
presence
common
diseases
(such
inflammation,
infection,
tumor)
also
briefly
reviewed.
Finally,
we
emphasized
current
challenges
possible
exploration
directions
Cell,
Journal Year:
2024,
Volume and Issue:
187(14), P. 3690 - 3711.e19
Published: June 5, 2024
Clonal
hematopoiesis
of
indeterminate
potential
(CHIP)
arises
from
aging-associated
acquired
mutations
in
hematopoietic
progenitors,
which
display
clonal
expansion
and
produce
phenotypically
altered
leukocytes.
We
associated
CHIP-DNMT3A
with
a
higher
prevalence
periodontitis
gingival
inflammation
among
4,946
community-dwelling
adults.
To
model
DNMT3A-driven
CHIP,
we
used
mice
the
heterozygous
loss-of-function
mutation
R878H,
equivalent
to
human
hotspot
R882H.
Partial
transplantation
Dnmt3aR878H/+
bone
marrow
(BM)
cells
resulted
mutant
into
both
myeloid
lymphoid
lineages
an
elevated
abundance
osteoclast
precursors
BM
osteoclastogenic
macrophages
periphery.
recipient
promoted
naturally
occurring
aggravated
experimentally
induced
arthritis,
enhanced
osteoclastogenesis,
IL-17-dependent
neutrophil
responses,
impaired
regulatory
T
cell
immunosuppressive
activity.
and,
subsequently,
were
suppressed
by
rapamycin
treatment.
CHIP
represents
treatable
state
maladaptive
promoting
inflammatory
loss.
