Barrier Membrane with Janus Function and Structure for Guided Bone Regeneration

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(36), P. 47178 - 47191

Published: Sept. 2, 2024

Guided bone regeneration (GBR) technology has been demonstrated to be an effective method for reconstructing defects. A membrane is used cover the defect stop soft tissue from growing into it. The biosurface design of barrier key technology. In this work, asymmetric functional gradient Janus was designed address bidirectional environment and during reconstruction. simply efficiently prepared by multilayer self-assembly technique, it divided polycaprolactone isolation layer (PCL layer, GBR-A) nanohydroxyapatite/polycaprolactone/polyethylene glycol osteogenic (HAn/PCL/PEG GBR-B). morphology, composition, roughness, hydrophilicity, biocompatibility, cell attachment, mineralization ability double surfaces were systematically evaluated. GBR-A smooth, dense, hydrophobic, which could inhibit adhesion resist invasion. GBR-B rough, porous, hydrophilic, bioactive, promoting adhesion, proliferation, matrix mineralization, expression alkaline phosphatase RUNX2. vitro in vivo results showed that bind tightly bone, maintain long-term space stability, significantly promote new formation. Moreover, fix filling material a better healing effect. This work presents straightforward viable methodology fabrication GBR membranes with Janus-based bioactive surfaces. may provide insights biomaterial treatment

Language: Английский

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Construction of a layer-by-layer self-assembled rosemarinic acid delivery system on the surface of CFRPEEK implants for enhanced anti-inflammatory and osseointegration activities

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(12), P. 3031 - 3046

Published: Jan. 1, 2024

Construction of a layer-by-layer self-assembled rosemarinic acid delivery system on the surface CFRPEEK implants and its biological functions: anti-inflammatory osteogenesis.

Language: Английский

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The Effect of Antibacterial-Osteogenic Surface Modification on the Osseointegration of Titanium Implants: A Static and Dynamic Strategy

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(7), P. 4093 - 4113

Published: June 3, 2024

Titanium (Ti) and its alloys are widely used biomaterials in bone repair. Although these possess stable properties good biocompatibility, the high elastic modulus low surface activity of Ti implants have often been associated with infection, inflammation, poor osteogenesis. Therefore, there is an urgent need to modify implants, where changes morphology or coatings loading can confer specific functions help them adapt osseointegration formation phase resist bacterial infection. This further ensure a healthy microenvironment for regeneration as well promotion immunomodulation, angiogenesis, this review, we evaluated various functional after modification, both terms static modifications dynamic response strategies, mainly focusing on synergistic effects antimicrobial activities functionalized osteogenic. Finally, current challenges future perspectives summarized provide innovative effective solutions defect

Language: Английский

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The osteoconductive properties of graphene-based material surfaces are finely tuned by the conditioning layer and surface chemistry

Materials Advances, Journal Year: 2024, Volume and Issue: 5(11), P. 4772 - 4785

Published: Jan. 1, 2024

The molecular layer that adsorbs on the biomaterial surface upon contacting body tissues and fluids, termed conditioning (CL), influences cell behavior regulating scaffold integration resilience in a patient-specific fashion.

Language: Английский

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Applications and Progress of 3D Printed Bioceramic Scaffolds in Bone Tissue Repair and Immune Regulation

Ceramics International, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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