Advanced Materials Interfaces,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 26, 2025
Abstract
As
the
core
component
of
ventricular
assist
devices,
blood
pumps
have
been
widely
used
in
clinical
treatment.
However,
thrombus
caused
by
contact
inner
surface
with
still
remain
a
serious
risk.
The
zwitterionic
coating
has
ability
to
form
hydration
layer
inhibit
protein
and
cell
adhesion,
which
makes
it
potential
strategy
solve
coagulation
on
device.
Herein,
phosphocholine
is
presented
formed
block
copolymer
poly(2‐methylacryloxyethyl
phosphatecholine‐
b
‐glycidyl
methacrylate
(PMPC‐
‐GMA).
Poly(MPC)
poly(GMA)
are
intended
provide,
respectively,
resistance
formation
adhesion
material
surface.
copolymers
synthesized
through
reversible
addition‐fragmentation
chain
transfer
polymerization
achieve
an
accurate
molecular
design.
After
dip‐coated
materials,
exhibits
platelet
ability,
anticoagulant
vitro
biocompatibility.
Furthermore,
vivo
biocompatibility
confirmed
implantation
coated
polycarbonate
substrate
rats.
This
study
provides
promising
pathway
for
regulating
interaction
between
biomaterials
proteins,
platelets,
bioactive
molecules,
expected
guide
further
development
coatings
ensure
safety
devices
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(11), P. 7202 - 7215
Published: Aug. 27, 2024
To
address
the
adverse
reactions
caused
by
implantation
of
blood-contacting
materials,
researchers
have
developed
different
strategies,
which
mimicking
multiple
key
features
endothelial
cells
is
most
effective.
However,
simultaneously
immobilizing
chemical
components
on
a
single
material
surface
and
maintaining
effects
individual
are
challenging.
In
this
work,
endothelium-mimicking
silicone
surfaces
were
incorporating
antifouling
polymer
poly(oligo(ethylene
glycol)
methacrylate),
glycosaminoglycan
analog
poly(sodium
4-vinyl-benzenesulfonate)
nitric
oxide
catalyst
(selenocystamine
dihydrochloride).
Through
rational
regulation
components,
harmoniously
resisted
nonspecific
protein
adsorption,
platelet
adhesion
activation
smooth
muscle
cell
hyperproliferation
while
promoting
proliferation
migration.
The
coculture
experiment
with
HUVECs
HUVSMCs
showed
that
optimum
selectivity
HUVECs/HUVSMCs
was
∼1.7.
This
work
contributes
insight
into
control
properties
selectivity,
providing
new
avenue
for
development
materials.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Abstract
Bioprosthetic
heart
valves
(BHVs)
for
transcatheter
replacement
often
face
deterioration
due
to
thrombosis,
inflammation,
and
calcification,
which
are
irreversible.
Here,
a
multidimensional
endothelium‐mimicking
healable
hydrogel
shielded
BHV
that
not
only
withstand
the
complex
valvular
physiological
hemodynamic
environment
but
also
able
reverse
damage‐induced
structural
degeneration
by
in
situ
healing
is
proposed.
Polydopamine/selenocystamine
nanoparticles
with
photothermal
effect
embedded
achieve
light‐triggered
catalytic
nitride
oxide
generation
polyvinyl
alcohol
coating
on
surface.
Additionally,
platelet
inhibitor
Tirofiban
encapsulated
shield
block
acute
coagulation
cascade
early
stage
after
implantation.
A
rodent
intravascular
leaflet‐like
implantation
model
developed
reveal
long‐term
hemocompatibility
of
BHVs
abdominal
aorta.
The
exhibit
enhanced
antithrombotic
properties,
reduced
superior
endothelialization,
improved
vascular
patency.
Transcriptome
analysis
indicates
better
endothelial
functions
BHVs.
Moreover,
maintains
both
mechanical
properties
biological
healing,
facilitated
great
fast
re‐endothelialization.
Collectively,
strategy
provides
new
insight
preventing
reversing
damage
instead
solely
replacement.
Advanced Materials Interfaces,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 26, 2025
Abstract
As
the
core
component
of
ventricular
assist
devices,
blood
pumps
have
been
widely
used
in
clinical
treatment.
However,
thrombus
caused
by
contact
inner
surface
with
still
remain
a
serious
risk.
The
zwitterionic
coating
has
ability
to
form
hydration
layer
inhibit
protein
and
cell
adhesion,
which
makes
it
potential
strategy
solve
coagulation
on
device.
Herein,
phosphocholine
is
presented
formed
block
copolymer
poly(2‐methylacryloxyethyl
phosphatecholine‐
b
‐glycidyl
methacrylate
(PMPC‐
‐GMA).
Poly(MPC)
poly(GMA)
are
intended
provide,
respectively,
resistance
formation
adhesion
material
surface.
copolymers
synthesized
through
reversible
addition‐fragmentation
chain
transfer
polymerization
achieve
an
accurate
molecular
design.
After
dip‐coated
materials,
exhibits
platelet
ability,
anticoagulant
vitro
biocompatibility.
Furthermore,
vivo
biocompatibility
confirmed
implantation
coated
polycarbonate
substrate
rats.
This
study
provides
promising
pathway
for
regulating
interaction
between
biomaterials
proteins,
platelets,
bioactive
molecules,
expected
guide
further
development
coatings
ensure
safety
devices
