RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer DOI Creative Commons
Huijie Yang, Min Xue, Peng Su

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2022, Volume and Issue: 41(1)

Published: Dec. 29, 2022

Recently genome-based studies revealed that the abnormality of Hippo signaling is pervasive in TNBC and played important role cancer progression. RING finger protein 31 (RNF31) comes to family E3 ubiquitin ligase. Our previously published have RNF31 elevated ER positive breast via activating estrogen suppressing P53 pathway.We used several cell lines xenograft models performed immuno-blots, QPCR, vivo investigate function progression.Here, we demonstrate plays tumor suppressive triple negative (TNBC). depletion increased proliferation migration vitro vitro. coupled with global genomic expression profiling indicated could be potential target for exert its function. Further data showed increase level YAP protein, genes lines, while clinical illustrated correlated longer relapse-free survival patients reversely level. The molecular biology assays implicated associate facilitate poly-ubiquitination degradation at K76 sites. Interestingly, also repress PDL1 sensitive immunotherapy inhibiting Hippo/YAP/PDL1 axis.Our study multi-faced different subtypes malignancies, activation a plausible strategy therapeutics.

Language: Английский

Peptide-Hydrogel Nanocomposites for Anti-Cancer Drug Delivery DOI Creative Commons
Farid Hajareh Haghighi, Roya Binaymotlagh, Ilaria Fratoddi

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(12), P. 953 - 953

Published: Dec. 4, 2023

Cancer is the second leading cause of death globally, but conventional anticancer drugs have side effects, mainly due to their non-specific distribution in body both cancerous and healthy cells. To address this relevant issue improve efficiency drugs, increasing attention being devoted hydrogel drug-delivery systems for different kinds cancer treatment high biocompatibility stability, low ease modifications. therapeutic provide multi-functionality, types nanoparticles (NPs) can be incorporated within hydrogels form smart nanocomposites, benefiting advantages counterparts suitable advanced applications. Despite many papers on non-peptide there limited knowledge about peptide-based specifically anti-cancer drug delivery. The aim short comprehensive review is, therefore, focus synergies resulting from combination NPs with hydrogels. This review, which includes a survey recent advances kind material, does not an exhaustive technology, it instead highlights noteworthy publications discusses novel perspectives valuable insights into promising synergic peptide design delivery systems.

Language: Английский

Citations

10
Bioresponsive nanocomplex integrating cancer-associated fibroblast deactivation and immunogenic chemotherapy for rebuilding immune-excluded tumors DOI
Lisha Liu, Beiyuan Zhang,

Xianggui Wu

et al.

Nanomedicine Nanotechnology Biology and Medicine, Journal Year: 2024, Volume and Issue: 58, P. 102743 - 102743

Published: March 13, 2024

Language: Английский

Citations

3
Targeting matrix metalloproteinases activating and Indoleamine 2,3-dioxygenase suppression for triple-negative breast Cancer multimodal therapy DOI
Xiaoxiao Hu, Qingqing Dou, P. Jiang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143289 - 143289

Published: April 1, 2025

Language: Английский

Citations

0
Recent advances in PD-L1 siRNA nanocarriers for cancer therapy DOI

Sristi,

Garima Gupta, Mohammed A. S. Abourehab

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143994 - 143994

Published: May 1, 2025

Language: Английский

Citations

0
RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer DOI Creative Commons
Huijie Yang, Min Xue, Peng Su

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2022, Volume and Issue: 41(1)

Published: Dec. 29, 2022

Recently genome-based studies revealed that the abnormality of Hippo signaling is pervasive in TNBC and played important role cancer progression. RING finger protein 31 (RNF31) comes to family E3 ubiquitin ligase. Our previously published have RNF31 elevated ER positive breast via activating estrogen suppressing P53 pathway.We used several cell lines xenograft models performed immuno-blots, QPCR, vivo investigate function progression.Here, we demonstrate plays tumor suppressive triple negative (TNBC). depletion increased proliferation migration vitro vitro. coupled with global genomic expression profiling indicated could be potential target for exert its function. Further data showed increase level YAP protein, genes lines, while clinical illustrated correlated longer relapse-free survival patients reversely level. The molecular biology assays implicated associate facilitate poly-ubiquitination degradation at K76 sites. Interestingly, also repress PDL1 sensitive immunotherapy inhibiting Hippo/YAP/PDL1 axis.Our study multi-faced different subtypes malignancies, activation a plausible strategy therapeutics.

Language: Английский

Citations

16