Bioactive Materials, Journal Year: 2025, Volume and Issue: 46, P. 555 - 568
Published: Jan. 13, 2025
Language: Английский
Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122968 - 122968
Published: Nov. 15, 2024
Language: Английский
Citations
7
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(7), P. 7345 - 7354
Published: April 4, 2024
Starvation therapy mediated by glucose oxidase is a widely used therapeutic approach for tumor treatment, but it limited the simultaneous drawbacks of weak efficacy, nonspecificity, and systemic toxicity. Thus, combination was to complement strategy anticancer therapy. On basis starvation therapy, we designed catalytic model nanosheets with biological cascade enzymes synergizing drugs. In short, two (glucose horseradish peroxidase) are covalently immobilized on Ti3C2 MXene nanosheet enzyme nanoreactor formed electrostatically adsorbing positive charged DOX. Finally, outer layer coated hyaluronic acid. By combining oxidase-mediated photothermal chemotherapy, have achieved effect "killing three birds one stone" dual stimulation response endogenous exogenous sources site. This method not only achieves targeting cancer cells also improves toxicity reduced efficacy realizes synergistic enhanced reactions. It opens up new path research nanomedicine.
Language: Английский
Citations
6
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(17)
Published: Dec. 24, 2023
Abstract Nano/micromotors (NMs) are tiny structures capable of converting various forms energy into mechanical motion at the micro and nanoscale. These motors operate in environments characterized by low inertia Reynolds numbers. The potential applications NMs vast, particularly fields biomedicine environmental science. One most intriguing developments this field is integration with surface‐enhanced Raman scattering (SERS) spectroscopy. SERS a powerful analytical technique that enhances intensity molecules, allowing for highly sensitive detection analysis trace amounts substances. This offers precise localized ultrasensing capabilities. combination can also facilitate real‐time imaging inside living organisms. has immense chemical cell biology medical diagnostics prognosis. Herein review describes types their fabrication, incorporation plasmonic nanostructures, creating strong electromagnetic when illuminated light, which turn signals significantly, applications, future prospects areas such as precision medicine, monitoring, possibly even new realms like microscale robotics targeted therapeutics.
Language: Английский
Citations
15
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(11), P. 2711 - 2719
Published: Jan. 1, 2024
Micro/nanomotors (MNMs) have evolved from single self-propelled entities to versatile systems capable of performing one or multiple biomedical tasks. When MNMs self-assemble into coordinated swarms, either under external control triggered by chemical reactions, they offer advantages that individual cannot achieve. These benefits include intelligent multitasking and adaptability changes in the surrounding environment. Here, we provide our perspective on evolution MNMs, beginning with development enzymatic since first theoretical model was proposed 2005. hold immense promise biomedicine due their biocompatibility fuel availability. Subsequently, introduce design application motors biomedicine, followed MNM swarms applications. In end, propose viable solutions for advancing anticipate valuable insights creation more controllable
Language: Английский
Citations
5
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(27)
Published: July 29, 2024
Abstract Micro/nanomotors represent a promising class of drug delivery carriers capable converting surrounding chemical or external energy into mechanical power, enabling autonomous movement. Their distinct propulsive force distinguishes them from other carriers, offering significant potential for enhancing penetration across cellular and tissue barriers. A comprehensive understanding micro/nanomotor dynamics with various power sources is crucial to facilitate their transition proof‐of‐concept clinical application. In this review, micro/nanomotors are categorized three classes based on sources: endogenously stimulated, exogenously live cell‐driven. The review summarizes the mechanisms governing movements under these explores factors influencing motion. Furthermore, it discusses methods controlling movement, encompassing aspects related structure, composition, environmental factors. remarkable exhibited by makes valuable biomedical applications, including tumor therapy, bio‐detection, bacterial infection inflammation gastrointestinal disease remediation. Finally, addresses challenges prospects application micro/nanomotors. Overall, emphasizes transformative in overcoming biological barriers therapeutic efficacy, highlighting applications fields.
Language: Английский
Citations
5
ChemPhysMater, Journal Year: 2024, Volume and Issue: 3(3), P. 273 - 283
Published: June 20, 2024
Micro-/nano-motors (MNMs) or swimmers are minuscule machines that can convert various forms of energy, such as chemical, electrical, magnetic into motion. These devices have attracted significant attention owing to their potential application in a wide range fields drug delivery, sensing, and microfabrication. However, diverse shapes, sizes, structural/chemical compositions, the development MNMs faces several challenges, understanding structure-function relationships, which is crucial for achieving precise control over motion within complex environments. In recent years, machine learning techniques shown promise addressing these challenges improving performance MNMs. Machine analyze large amounts data, learn from patterns, make predictions, thereby enabling navigate environments, avoid obstacles, perform tasks with higher efficiency reliability. This review introduces current state-of-the-art MNM research, particular focus on employing understand manipulate navigation locomotion Finally, we discuss opportunities this field suggest future research directions.
Language: Английский
Citations
4
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125201 - 125201
Published: Jan. 10, 2025
Language: Английский
Citations
0
Biosensors, Journal Year: 2025, Volume and Issue: 15(2), P. 115 - 115
Published: Feb. 16, 2025
Surface-enhanced Raman spectroscopy (SERS) has emerged as a powerful noninvasive analytical technique with widespread applications in biochemical analysis and biomedical diagnostics. The need for highly sensitive, reproducible, efficient detection of biomolecules complex biological environments driven significant advancements SERS-based biosensing platforms. In this context, micro/nanomachines (MNMs) have garnered attention versatile SERS-active substrates due to their unique structural motional characteristics at the micro- nanoscale. This review explores advantages integrating MNMs SERS biosensing, discussing recent technological advances, various propulsion strategies, potential range applications.
Language: Английский
Citations
0
Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0
Applied Materials Today, Journal Year: 2025, Volume and Issue: 43, P. 102673 - 102673
Published: March 13, 2025
Citations
0