FlexMat.,
Journal Year:
2024,
Volume and Issue:
1(3), P. 269 - 301
Published: Aug. 29, 2024
Abstract
Electroconductive
hydrogels
(ECHs)
have
been
extensively
explored
as
promising
flexible
materials
for
bioelectronics
because
of
their
tunable
conductivity
and
tissue‐like
biological
mechanical
properties.
ECHs
can
interact
intimately
with
biosystems,
transmit
physiological
signals,
are
expected
to
revolutionize
the
convergence
between
organisms
electronics.
However,
there
still
some
challenges
in
utilizing
bioelectronics,
such
mismatched
stretchability
tissues,
a
lack
environmental
adaptability,
susceptibility
damage,
inferior
interface
compatibility,
vulnerability
bacterial
contamination.
This
review
categorizes
these
encountered
bioelectronic
applications
elaborates
on
strategies
theories
improving
performance.
Furthermore,
we
present
an
overview
recent
advancements
applications,
specifically
focusing
contributions
healthcare
monitoring,
treatment
diseases,
human–machine
interfaces.
The
scope
future
research
is
also
proposed.
Overall,
this
offers
comprehensive
exposition
difficult
issues
potential
opportunities
offering
valuable
insights
design
fabrication
ECH‐based
devices.
Ischemic
heart
disease
morbidity
and
mortality
ensue
as
the
ventricle
remodels,
cardiac
function
is
lost
following
myocardial
infarction.
Previous
studies
have
shown
that
applying
a
biodegradable,
elastic
epicardial
patch
onto
ischemic
wall
preserves
alters
remodeling
process.
In
this
report,
capacity
to
deliver
recombinant
adeno-associated
virus
(AAV)
encoding
human
vascular
endothelial
growth
factor
(VEGF)
was
evaluated
determine
if
it
would
provide
benefit
beyond
alone.
Coaxial
electrospinning
of
poly(ether
ester
urethane)
urea
generated
microfibrous
patches
with
fibers
loaded
in
their
core
VEGF–AAV
poly(ethylene
oxide)
or
vehicle
rat
infarction
model,
were
placed
3
days
post-infarction.
Over
an
8
week
period
intervention,
end-diastolic
area
lower
ejection
fraction
greater
patch-VEGF
group
compared
control
sham
surgery
groups.
There
also
number
α-SMA-positive
cells,
blood
vessels,
positive
immunostaining
for
VEGF
groups
having
lacking
VEGF.
The
approach
combining
mechanical
(patch)
biofunctional
(controlled
release
angiogenic
therapy)
support
through
scaffold-based
gene
vector
transfer
may
be
effective
option
dealing
adverse
ventricular
leads
end-stage
cardiomyopathy.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 4, 2025
Abstract
Despite
the
development
of
many
injectable
hydrogels
intended
for
repair
myocardial
infarction
(MI),
their
effectiveness
is
often
compromised
because
they
target
merely
one
or
two
phases
MI's
pathological
progression.
Here,
a
multifunctional
hydrogel
delivery
platform
prepared
with
brand‐new
small
molecule
cross‐linker
stepwise
treatment
MI.
The
synthesis
and
reporting
novel
small‐molecule
phenylboronic
acid
((N(BA)
3
))
precise
molecular
structure
conducted
first
time,
it
successfully
utilized
polyvinyl
alcohol
(PVA)
dopamine
to
prepare
infarct
microenvironmental
responsiveness
anti‐oxidant.
Further,
considering
multistage
MI
repair,
contains
both
hyperoside
bioactive
nanoparticles
(EGCG@Hyp&Arg
NPs)
PLGA
microspheres
loaded
galunisertib
(PLGA@Gal
Ms).
EGCG@Hyp&Arg
NPs
are
rapidly
released
demonstrate
anti‐inflammatory
pro‐angiogenesis
effects,
while
in
long
term,
Gal
from
PLGA@Gal
Ms
inhibit
fibrosis
improve
cardiac
function.
Results
vitro
vivo
studies
reveal
that
engineered
programmed
capabilities
anti‐oxidation,
reducing
inflammation,
promoting
new
blood
vessel
formation,
inhibiting
fibrosis,
thereby
significantly
enhancing
heart
function
post‐MI.
Overall,
this
has
great
potential
application
as
therapeutic
strategy
Biomacromolecules,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Myocardial
infarction
(MI)
remains
one
of
the
leading
causes
mortality
worldwide,
necessitating
advanced
therapeutic
strategies
to
address
resulting
electrical
disconnection
and
pathological
remodeling.
This
study
developed
a
conductive
hydrogel
by
covalently
cross-linking
silk
fibroin
hyaluronic
acid,
integrating
MXene
nanosheets
mimic
extracellular
matrix
(ECM).
Results
demonstrated
that
incorporation
significantly
enhanced
hydrogel's
conductivity,
with
SH-M5
exhibiting
highest
conductivity
0.32
S/m.
The
effectively
improved
signal
transmission
recovery
left
ventricular
function
in
myocardial
infarction.
These
findings
underscore
transformative
role
enhancing
functional
properties
hydrogels
for
repair.
unique
capacity
integrate
mechanical
reinforcement,
biocompatibility,
presenting
promising
platform
treating
advancing
regenerative
medicine.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 30, 2025
Abstract
Ischemic
cardiomyopathy
remains
high
mortality
and
morbidity
worldwide
due
to
dysfunctional
cell
metabolism
programmed
death
of
cardiomyocytes.
Restoration
the
blocked
blood
flows
is
a
major
therapeutic
approach
against
ischemic
cardiomyopathy,
which,
unfortunately,
may
cause
burst
oxidative
species
damaging
tissues
(ischemic/reperfusion
injury,
IR).
Cardiac
antioxidation
revascularization
are
two
aims
in
treating
cardiac
IR
as
well
myocardial
infarction
(MI).
In
present
work,
strontium
hexacyanoferrate
(SrHF)
nanoparticles
synthesized
for
alleviating
both
pathologies
MI
concurrently.
SrHF
features
antioxidative
catalytic
activity,
mimicking
superoxide
dismutase
catalase
eliminating
reactive
oxygen
protection.
vivo,
investigation
confirms
that
has
significantly
alleviated
functional
deterioration
enhanced
cardiomyocyte
survival.
Mechanistic
studies
demonstrate
can
effectively
inhibit
pyroptosis
pathological
remodeling
through
enhance
angiogenesis
by
bioactive
ions.
The
work
provides
promising
strategy
pathologies,
providing
fundamental
basis
clinical
translation
application
toward
cardiovascular
diseases.
