Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113607 - 113607
Published: March 5, 2025
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Feb. 21, 2024
Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management
Language: Английский
Citations
147
Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 17, 2025
Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.
Language: Английский
Citations
2
Royal Society Open Science, Journal Year: 2024, Volume and Issue: 11(4)
Published: April 1, 2024
Despite remarkable progress in medical sciences, modern man is still fighting the battle against cancer. In 2022, only USA, 640 000 deaths and 2 370 patients were reported because of Chemotherapy most widely used for cancer treatments. However, chemotherapeutics have severe physicochemical side effects. Therefore, we prepared poly(amididoamine) dendrimeric carrageenan (CG), sodium alginate (SA) poly(vinyl alcohol) (PVA) hydrogels by using solution casting methodology. The constituents cross-linked mutable quantity 3-aminopropyl(diethoxy)methyl silane (APDMS). Hydrogels characterized Fourier transform infrared spectroscopy, thermal gravimetric analysis, scanning electron microscope atomic force microscopy. exhibited higher swelling volumes 5–7 pH range. vitro biodegradation ribonuclease-A cytocompatibility analysis DF-1 fibroblasts established their biodegradable non-toxic nature, which enables them as a suitable carrier chemotherapeutic compounds. Hence, methotrexate (MTX) model drug was loaded on CAP-8 hydrogel its release detected UV–visible spectrophotometer phosphate-buffered saline (PBS) solution. 13.5 h, 81.25% 77.23% MTX released at 7.4 (blood pH) 5.3 (tumour PBS, respectively. super case II mechanism best fitted to zero-order Korsmeyer–Peppas model. synthesized APDMS CG/SA/PVA could be an efficient platform effective delivery
Language: Английский
Citations
7
Actualidades Biológicas, Journal Year: 2025, Volume and Issue: 74(122)
Published: Jan. 1, 2025
Las enfermedades autoinmunes son trastornos complejos caracterizados por una respuesta inmune anormal. En estas enfermedades, el sistema identifica erróneamente diferentes componentes del propio organismo como extraños, lo que provoca inflamación crónica y daño en múltiples sistemas de órganos tejidos. Los tratamientos actuales suelen implicar uso fármacos inmunosupresores suprimen ampliamente la inmune. Aunque estos medicamentos pueden ayudar a aminorar los síntomas, también conlleva importantes efectos secundarios debido su naturaleza inespecífica. La nanotecnología, través nanomedicina, juega un papel crucial tratamiento mejorando eficacia terapéutica minimizando toxicidad. Esta tecnología permite mejorar biodisponibilidad medicamentos, distribución más precisa cuerpo control exacto sobre liberación fármacos. nanopartículas (NP) fundamentales este proceso, capaces superar barreras biológicas dirigir directamente sitios afectados, aumenta reduce secundarios. Este enfoque es especialmente prometedor cáncer, donde las NP dirigirse células específicas, macrófagos, monocitos, dendríticas linfocitos B, para entregar manera efectiva, con menos toxicidad adversos. investigación nanotecnología continúa avanzando, ofreciendo esperanza efectivos personalizados.
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113607 - 113607
Published: March 5, 2025
Language: Английский
Citations
0