Construction of a pH-responsive nanoreactor and its specific inhibition of oral squamous cell carcinoma growth via TME and xCT/GSH/GPX4 axis DOI Creative Commons
Daming Wu, Xiao Ran Zhao,

Diya Leng

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 18, 2023

Abstract Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in oral and maxillofacial region, distinguished by its formidable invasiveness, high incidence of lymph node metastatic, unfavorable prognosis. Given current dearth specific drugs, effectively curtailing growth, invasion, metastasis poses a significant challenge. The microenvironment (TME) exhibits mildly acidic conditions concentration H 2 O , which makes use this characteristic for cancer treatment promising approach. In study, we developed pH-responsive nanoreactor, composed ultrasmall Prussian blue nanoparticles within mesoporous calcium-silicate (USPBNs@MCSNs, UPM). This innovative nanoreactor converted endogenous TME into abundant ·OH while generating oxygen non-tumor regions to reduce hypoxia-induced chemotherapy resistance. findings showed UPM induced OSCC cells ferroptosis downregulated xCT/GPX4/GSH axis, restraining migration, invasion cells, did not cause systemic toxicity. Consequently, synthesized here possesses ability initiate biochemical reactions TEM, has potential clinical application value.

Language: Английский

An Acid-Responsive Iron-Based Nanocomposite for OSCC Treatment DOI
Xudong Zhao, Dong Leng, Honggang Wang

et al.

Journal of Dental Research, Journal Year: 2024, Volume and Issue: 103(6), P. 612 - 621

Published: April 29, 2024

Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer, characterized by invasiveness, local lymph node metastasis, and poor prognosis. Traditional treatment medications have limitations, making specific inhibition OSCC growth, invasion, metastasis a challenge. The tumor microenvironment exhibits mildly acidity high concentrations H

Language: Английский

Citations

7
Flying‐Saucer‐Shaped Nanoheterojunctions with Enhanced Colorectal Tumor Accumulation for Increased Oxidative Stress and Immunometabolic Regulation DOI

Ya Ma,

Yingui Cao,

Menghang Zu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 2, 2024

Abstract The treatment outcomes of nanomedicines against colorectal cancer are severely restricted by their insufficient accumulation in the tumor tissues, unsatisfactory antitumor effect, and weak immunometabolic modulation. To address these issues, flying‐saucer‐shaped nanoheterojunctions coating copper oxide (Cu x O) onto surface PEGylated zinc (ZnO) nanoparticles constructed. When exposed to ultrasound, resultant Cu O@ZnO exhibit increased locomotor activities, facilitating mucus infiltration, deep penetration, cell internalization. decoration O suppresses rapid recombination electrons holes promoting production singlet oxygen hydroxyl radical, which generated through a Fenton‐like chemodynamic reaction sonodynamic reaction. After rectal administration, sono‐chemodynamic plus PD‐L1 antibodies effectively inhibit growth orthotopic distant tumors. It elicits responses inducing immunogenic death, activating interferon genes signaling pathway stimulator, inhibiting glucose transport glycolytic pathways. This combined modality also increases proportion beneficial microbes ( e.g ., Bifidobacterium ) decreases abundance harmful microorganisms Romboutsia intestine. ultrasound antibodies) is promising strategy for synergistic cancer.

Language: Английский

Citations

6
A novel therapeutic outlook: Classification, applications and challenges of inhalable micron/nanoparticle drug delivery systems in lung cancer (Review) DOI Creative Commons

Lixin Xie,

Daihan Xie,

Zhefei Du

et al.

International Journal of Oncology, Journal Year: 2024, Volume and Issue: 64(4)

Published: Feb. 21, 2024

Lung cancer represents a marked global public health concern. Despite existing treatment modalities, the average 5‑year survival rate for patients with lung is only ~20%. As there are numerous adverse effects of systemic administration routes, an urgent need to develop novel therapeutic strategy tailored specifically cancer. Non‑invasive aerosol inhalation, as route drug administration, holds unique advantages in context respiratory diseases. Nanoscale materials have extensive applications field biomedical research recent years. The present study provides comprehensive review classification, summarized according clinical modalities and challenges associated inhalable micron/nanoparticle delivery systems (DDSs) Achieving localized preclinical models through inhalation deemed feasible. However, further required substantiate efficacy long‑term safety DDSs management

Language: Английский

Citations

5
Self-assembled methodologies for the construction of DNA nanostructures and biological applications DOI
Rui Ye, Yuqi Wang, Yan Liu

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(15), P. 3712 - 3724

Published: Jan. 1, 2024

Overview of the methodologies and applications DNA self-assembly, including conventional strategy based on Watson–Crick base-pairing, hybrid assembly mediated by functional elements their in biological fields.

Language: Английский

Citations

4
The enhancing effect of DNA tetrahedron-based lactoferrin as an assembled adjuvant in immunotherapy DOI
Miaomiao Xu, Tian‐Hua Zhou, Bowen Yang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 506, P. 159941 - 159941

Published: Jan. 1, 2025

Language: Английский

Citations

0
Hierarchical DNA Octahedral Nanoplatform for in Situ Biosensing and Clinical Monitoring of Acute Lymphoblastic Leukemia DOI Open Access
Qian Liu, Man Shen, Hanqing Xu

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Abstract Developing nanoscale platforms with high integration, assembly efficiency, and structural stability for performing complex computations in specific cells remains a significant challenge. To address this, the Three‐dimensional Hierarchical Octahedral Robotic (THOR) DNA nanoplatform is introduced, which integrates targeting, logic computation, sensing modules within single framework. This specifically binds to cancer cell surface proteins, releasing aptamer‐linked fuel chains initiate subsequent computational processes. Three gates efficiently compute any arbitrary binary combination of target proteins. The module employs catalytic hairpin detecting miRNAs sensitivity. THOR demonstrates robust functionality both vitro situ. As proof‐of‐concept, this distinguish acute lymphoblastic leukemia (ALL) patients from other subtypes healthy participants, achieving 100% accuracy applied. Additionally, approach reliably monitored therapeutic progress ALL patients, showing strong concordance bone marrow smear results. platform highlights feasibility constructing reliable, hierarchical, multifunctional analytical system based on polyhedron. It offers promising auxiliary tool clinical diagnostics monitoring.

Language: Английский

Citations

0
Tetrahedral-DNA-Nanostructure-Modified Engineered Extracellular Vesicles Enhance Oral Squamous Cell Carcinomas Therapy by Targeting GPX4 DOI
Dianri Wang, Yun Wang, Sicheng Zhang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Oral squamous cell carcinoma (OSCC) represents a heterogeneous group of malignancies originating from the mucosal lining oral cavity. Current treatment modalities primarily involve surgery, chemotherapy, and radiotherapy. Despite use multimodal therapy, 5 year overall survival rate for OSCC remains around 50%, underscoring need development nontoxic agents with potent antitumor activity. Extracellular vesicles (EVs) are nanoscale, membrane-bound structures that can selectively deliver small molecules, nucleic acids, proteins to target cells, making them promising platform drug delivery in cancer therapy. Strategies improve uptake EVs enhance therapeutic molecules cells critical advancing precision medicine. Tetrahedral DNA nanostructures (TDNs) have shown significant potential facilitating endocytosis delivery, as well improving tissue penetration. In this study, TDN@EVs were conducted by modifying membrane surface M1-EVs TDNs, which demonstrated improved biological stability efficiency compared unmodified EVs. vitro vivo experiments showed significantly inhibited proliferation migration while promoting apoptosis. exhibited superior penetration properties, further amplifying their effects. Proteomic analysis identified Hsc70 key protein responsible activity TDN@EVs. The efficient into tumor led degradation GPX4, inducing ferroptosis, mitochondrial stress, damage cells. These findings highlight an effective safe approach conclusion, present strategy targeted treatment, offering enhanced stability,

Language: Английский

Citations

0
Inhalable pH-responsive core-shell nanocarriers with PEGylated chitosan/alginate layer-by-layer coating for sequential drug release in lung cancer therapy DOI

Mariam Hossam Eldin,

Reem K. Arafa,

Osman Gamal

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141851 - 141851

Published: March 1, 2025

Language: Английский

Citations

0
Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies DOI Creative Commons
Fan Xu, Yao Liu, Zujun Que

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Metastasis is the leading cause of death in patients with lung cancer. Multidisciplinary comprehensive treatments (MDT), including surgery, chemotherapy, radiotherapy, gene-targeted therapy, immunotherapy, antibody-drug conjugate (ADC), natural products, etc., have been currently used for cancer metastasis. The MDT model has shown promising efficacy against metastasis clinical practice. However, these therapies some limitations, such as unusual toxic side effects, drug resistance, limited indications, and high costs. Therefore, emerging technological platforms are imperative to overcome bottlenecks. Nanomedicine can be prepare efficient delivery systems owing its good biocompatibility, targeting, responsive release, multidrug codelivery plays an important role synergistic antimetastasis because optical, acoustic, electrical, thermal, magnetic functions. This review analyses limitations model, briefly outlines advantages nanotechnology, introduces nanodrug systems, summarizes nanostrategies based on invasion-metastasis cascade process, provides a summary prospects challenges translation nanomedicines.

Language: Английский

Citations

0
Stem Cells Recruited from Multifunctional Tetrahedral Framework Nucleic Acids Induce Vascularized Osteogenesis to Repair Bone Defects DOI
Sirong Shi,

Hang Liao,

Weitong Lu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Abstract Repairing and reconstructing massive bone defects remains a critical clinical challenge. Recruiting early stem cells, promoting their angiogenesis osteogenesis are crucial for the initiation of efficient in situ regeneration repair. This study aims to promote reconstruct using tetrahedral framework nucleic acids (tFNAs) with Apt19S, microRNA‐21 (miR21), morphogenetic protein 2 (BMP2) (Apt19S‐tFNAs‐miR21/BMP2 [ATMB]). ATMB promotes proliferation, migration, recruitment mesenchymal cells (BMSCs), alkaline phosphatase activity, osteogenesis‐related mRNAs proteins vitro. The angiogenesis‐related genes HUVECs effectively enhanced by ATMB. Furthermore, chitosan hydrogel fills extends duration drug action, combining form ATMCB. ATMCB is highly at recruiting BMSCs, matrix mineralization, new formation rat calvarial size vivo. demonstrates promising approach defect repair that overcomes traditional limitations cell‐delivery therapy.

Language: Английский

Citations

0