Materials chemistry horizons., Journal Year: 2024, Volume and Issue: 3(3), P. 1 - 14
Published: Dec. 1, 2024
Language: Английский
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124481 - 124481
Published: July 23, 2024
Language: Английский
Citations
10
Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117897 - 117897
Published: Feb. 7, 2025
Language: Английский
Citations
1
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 674, P. 125427 - 125427
Published: March 11, 2025
Language: Английский
Citations
1
Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101782 - 101782
Published: April 19, 2025
Language: Английский
Citations
1
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)
Published: March 28, 2024
Abstract Leukemia is a widespread hematological malignancy characterized by an elevated white blood cell count in both the and bone marrow. Despite notable advancements leukemia intervention clinic, large proportion of patients, especially acute fail to achieve long‐term remission or complete following treatment. Therefore, therapy necessitates optimization meet treatment requirements. In recent years, multitude materials have undergone rigorous study serve as delivery vectors direct agents bolster effectiveness therapy. These include liposomes, protein‐based materials, polymeric cell‐derived inorganic materials. They possess unique characteristics are applied broad array therapeutic modalities, including chemotherapy, gene therapy, immunotherapy, radiotherapy, hematopoietic stem transplantation, other evolving treatments. Here, overview these presented, describing their physicochemical properties, role treatment, challenges they face context clinical translation. This review inspires researchers further develop various that can be used augment efficacy multiple modalities for novel applications
Language: Английский
Citations
6
Matter, Journal Year: 2025, Volume and Issue: unknown, P. 102006 - 102006
Published: Feb. 1, 2025
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 647 - 669
Published: Jan. 1, 2025
Language: Английский
Citations
0
Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 359 - 359
Published: March 1, 2025
Modernization of existing methods for the delivery mRNA is vital in advanced therapeutics. Traditionally, has faced obstacles poor stability due to enzymatic degradation. This work examines cutting-edge formulation and emerging techniques safer vaccines. Inspired by success lipid nanoparticles (LNP) delivering vaccines COVID-19, a variety other formulations have been developed deliver diverse infections. The meritorious features nanoparticle-based strategies, including LNP, polymeric, dendrimers, polysaccharide-based, peptide-derived, carbon metal-based, DNA nanostructures, hybrid, extracellular vesicles, examined. impact these platforms on vaccine efficacy, protection from degradation, cellular uptake, controlled release, immunogenicity discussed detail. Even with significant developments, there are certain limitations overcome, toxicity concerns, limited information about immune pathways, need maintain cold chain, necessity optimizing administration methods. Continuous innovation essential improving systems Future research directions proposed address challenges expand their potential prophylactic therapeutic application.
Language: Английский
Citations
0
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 25, 2025
Advanced gastric cancer remains a significant global health challenge, with limited therapeutic options available. In contrast, immunotherapy have emerged as promising alternatives, offering greater potency in treating advanced cancer. However, the development of novel and efficient immunotherapeutic strategy is crucial to enhance body's immune response against This study developed single-injection peptide hydrogel-based nanovaccine therapy for treatment. The utilizes RADA32 hydrogel, which sensitive metal ion concentration, encapsulate manganese ions HPPS nanovaccines. nanovaccines contain antigen CpG-ODN, designed activate both toll-like receptor 9 (TLR9) cGAS-STING signaling pathways antigen-presenting cells. design aims facilitate stable sustained release nanovaccine, thereby enhancing effective recognition antigens. efficacy system was confirmed using model OVA cancer-specific MG7-related peptide. results demonstrated that effectively activated response, leading enhanced activation TLR9 cells observed highlighting potential this approach stimulate robust presents clinical anti-tumor vaccine administration, prevention treatment provides convenient method could potentially be expanded other types cancer, providing versatile platform immunotherapy.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0