Recent development of oral vaccines (Review)

Experimental and Therapeutic Medicine, Journal Year: 2024, Volume and Issue: 27(5)

Published: March 22, 2024

Oral immunization can elicit an effective immune response and tolerance to specific antigens. When compared with the traditional injection route, delivering antigens via gastrointestinal mucosa offers superior effects compliance, as well simplicity convenience, making it a more optimal route for immunization. At present, various oral vaccine delivery systems exist. Certain modified bacteria, such Salmonella, Escherichia coli particularly Lactobacillus, are considered promising carriers vaccines. These significantly enhance efficiency by actively replicating in intestinal tract following administration. The present review provided discussion of main mechanisms immunity research progress made field Additionally, introduced advantages disadvantages currently commonly administered injectable COVID‑19 vaccines, alongside latest advancements this area. Furthermore, recent developments vaccines summarized, their potential benefits side discussed.

Language: Английский

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Innovative Strategies to Enhance mRNA Vaccine Delivery and Effectiveness: Mechanisms and Future Outlook

Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(14), P. 1049 - 1059

Published: March 29, 2024

Abstract: The creation of mRNA vaccines has transformed the area vaccination and allowed for production COVID-19 with previously unheard-of speed effectiveness. development novel strategies to enhance delivery efficiency been motivated by ongoing constraints present vaccine systems. In this context, intriguing methods get beyond these restrictions include lipid nanoparticles, self-amplifying RNA, electroporation, microneedles, cell-targeted administration. These innovative could increase effectiveness, safety, use vaccines, making them more efficient, effective, broadly available. Additionally, technology may have numerous far-reaching uses in field medicine, opening up fresh avenues diagnosis treatment disease. This paper gives an overview existing drawbacks techniques, creative solutions created address drawbacks, their prospective public health implications. illnesses other than infectious diseases creating scalable affordable manufacturing processes are some future directions research that covered paper.

Language: Английский

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Nanocapsules Comprised of Purified Protein: Construction and Applications in Vaccine Research

Vaccines, Journal Year: 2024, Volume and Issue: 12(4), P. 410 - 410

Published: April 12, 2024

Nanoparticles show great promise as a platform for developing vaccines the prevention of infectious disease. We have been investigating method whereby nanocapsules can be formulated from protein, such that final capsules contain only cross-linked protein itself. Such are made using silica templating system and customised in terms size porosity. Here we compare construction characteristics four different proteins: one model (ovalbumin) three disease pathogens, namely influenza virus, Helicobacter pylori HIV. Two were assessed further. confirm constructed urease A subunit H. reduce subsequent infection vaccinated mouse model. Further, HIV gp120 taken up by dendritic cells tissue culture recognised antibodies raised against virus. These results point to utility this constructing protein-only proteins varying sizes isoelectric points.

Language: Английский

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Administration sequence- and formation-dependent vaccination using acid-degradable polymeric nanoparticles with high antigen encapsulation capability

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(27), P. 6577 - 6586

Published: Jan. 1, 2024

Acid-degradable polymeric nanoparticles with a high capability of GFP encapsulation demonstrate efficient antibody production in combination booster injection free antigens.

Language: Английский

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Hyperbranched polyglycerol grafted poly(N,N-diethylacrylamide) thermoresponsive copolymers as biocompatible, highly efficient encapsulation and sustained release systems of curcumin

European Polymer Journal, Journal Year: 2024, Volume and Issue: 219, P. 113378 - 113378

Published: Aug. 9, 2024

Due to solubilization, encapsulation, stability and delivery difficulties of various drugs drug candidates, investigating polymeric nanoparticles for formulations is an extremely vital challenging task. The ideal polymers should have biocompatibility, controlled uptake/release properties colloidal over a wide temperature range. In this study, we propose poly(N,N-diethylacrylamide)-g-(hyperbranched polyglycerol) (PDEAAm-g-HbPG) thermoresponsive graft copolymers as candidates satisfying all the above-mentioned requirements. PDEAAm-g-HbPG were synthesized by grafting amino-monofunctional HbPG onto PDEAAm chains containing pendant succinimide active ester groups. It has been found that are non-toxic human monocytic cells, do not cause haemolysis red blood cells. Furthermore, these grafts possess temperature-dependent reversible aggregation-disaggregation, i.e. transitions, in water PBS. specific nanoassembling architecture resulted enhanced encapsulation curcumin with high loading content exceeding 25 % at 37 °C. hydrophilic side provide formulated dispersions from room up 45 °C well sustained release curcumin. Formulating novel significantly its anticancer activity against HT-29 colorectal adenocarcinoma cells cell internalization drug. These make them superior compared other hydrophilically modified polymer carriers indicating their great potential advanced systems.

Language: Английский

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Nano-Vaccines: Opportunities and Challenges in Biomaterial-Based Vaccine Delivery

Published: Jan. 1, 2024

Language: Английский

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Peptide hydrogel platform encapsulating manganese ions and high-density lipoprotein nanoparticle-mimicking nanovaccines for the prevention and treatment of gastric cancer

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

While chemotherapy and radiotherapy may alleviate symptoms prolong survival in patients with advanced gastric cancer, their efficacy is constrained. In contrast, immunotherapies, including immune checkpoint inhibitors, T-cell transfer therapy, therapeutic vaccines, demonstrate greater potency treating cancer. This study developed a single-injection peptide hydrogel-based nanovaccine therapy for cancer treatment. The employs RADA₃₂ hydrogel, sensitive to metal ion concentration, encapsulating manganese ions HPPS nanovaccines (containing antigen peptides CpG-ODN) facilitate stable, sustained release of the nanovaccine. strategy activates both toll-like receptor 9 cGAS-STING signaling pathways antigen-presenting cells, enhancing body's effective recognition response antigens. system's was confirmed using model OVA cancer-specific MG7-related peptide. approach offers novel clinical anti-tumor vaccine administration be applicable preventing

Language: Английский

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Functionalized Calcium Carbonate-Based Microparticles as a Versatile Tool for Targeted Drug Delivery and Cancer Treatment

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 653 - 653

Published: May 13, 2024

Nano- and microparticles are increasingly widely used in biomedical research applications, particularly as specific labels targeted delivery vehicles. Silica has long been considered the best material for such vehicles, but it some disadvantages limiting its potential, proneness of silica-based carriers to spontaneous drug release. Calcium carbonate (CaCO3) is an emerging alternative, being easily available, cost-effective, biocompatible with high porosity surface reactivity, which makes attractive choice delivery. CaCO3 particles this field form either bare microbeads or core/shell representing polymer-coated cores. In addition, they serve removable templates obtaining hollow polymer microcapsules. Each these types advantages terms applications. primarily due their capacity carrying pharmaceutics, whereas systems ensure better protection drug-loaded core from environment. Hollow capsules because can encapsulate large amounts pharmaceutical agents be so designed release contents target site response stimuli. This review focuses first on chemistry cores, microbeads, Then, using structures therapeutic agents, including drugs, proteins, DNA, outlined. The results systematic analysis available data presented. They show that encapsulation various CaCO3-based microcapsules a promising technique delivery, especially cancer therapy, enhancing bioavailability targeting cells while reducing side effects. To date, assembled mainly dealt properties vitro, vivo behavior still remains poorly studied. However, enormous potential highly applications undoubted. last issue addressed depth Conclusions Outlook sections review.

Language: Английский

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Sustained exposure to multivalent antigen-decorated nanoparticles generates broad anti-coronavirus responses

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Summary The threat of future coronavirus pandemics requires developing cost-effective vaccine technologies that provide broad and long-lasting protection against diverse circulating emerging strains. Here we report a multivalent liposomal hydrogel depot technology comprising the receptor binding domain (RBD) up to four relevant SARS MERS strains non-covalently displayed on surface liposomes within structure. presentation sustained exposure RBD antigens improved potency, neutralizing activity, durability, consistency antibody responses across homologous heterologous in naïve murine model. When administrated animals previously exposed wild-type SARS-CoV-2 antigens, hydrogels elicited durable for over 6 months activity immune-evasive variant Omicron BA.4/BA.5. Overall, tunable antigen-decorated platform here generates robust humoral coronaviruses, supporting global efforts effectively respond viral outbreaks. Progress Potential Rapidly mutating infectious diseases such as influenza, HIV, COVID-19 pose serious threats human health. Yet, most vaccines still do not mount mutagenic viruses fail induce protect emergent Materials approaches design, employing delivery or decorating nanoparticle constructs with multiple have shown promise improving breadth potency vaccines. these typically require cumbersome chemistries been explored pre-exposed populations clinically time scales. Here, development an injectable capable prolonged coordinated forming These improve durability response are easy fabricate, enabling rapid design next generation confer rapidly evolving pandemics.

Language: Английский

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Beyond Needles: Immunomodulatory Hydrogel-Guided Vaccine Delivery Systems

Gels, Journal Year: 2024, Volume and Issue: 11(1), P. 7 - 7

Published: Dec. 26, 2024

Vaccines are critical for combating infectious diseases, saving millions of lives worldwide each year. Effective immunization requires precise vaccine delivery to ensure proper antigen transport and robust immune activation. Traditional systems, however, face significant challenges, including low immunogenicity undesirable inflammatory reactions, limiting their efficiency. Encapsulating or binding vaccines within biomaterials has emerged as a promising strategy overcome these limitations. Among biomaterials, hydrogels have gained considerable attention biocompatibility, ability interact with biological potential modulate responses. Hydrogels offer materials science-driven approach targeted delivery, addressing the shortcomings conventional methods while enhancing efficacy. This review examines hydrogel-based systems improve explores dual role immunomodulatory adjuvants. Innovative methods, such microneedles, patches, inhalable discussed minimally invasive alternatives traditional administration routes. Additionally, this addresses safety, scalability, regulatory considerations, offering insights into hydrogel-guided strategies eliciting responses advancing global efforts.

Language: Английский

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