Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 378, P. 849 - 863
Published: Dec. 31, 2024
Transarterial radioembolization (TARE) is a recommended locoregional strategy for intermediate hepatocellular carcinoma (HCC), whereas, the effect insufficient to reverse immunosuppression tumor microenvironment, and overall benefits patients remain be improved. In this study, multifunctional microsphere (MS)
Language: Английский
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 180, P. 1 - 17
Published: April 10, 2024
This analysis explores the principal regulatory concerns linked to nanomedicines and gene vaccines, including complexities involved perspectives on how navigate them. In realm of nanomedicines, ensuring safety nanomaterials is paramount due their unique characteristics potential interactions with biological systems. Regulatory bodies are actively formulating guidelines standards assess risks associated nanomedicine products, emphasizing need for standardized characterization techniques accurately gauge effectiveness. Regarding frameworks must be tailored address distinct challenges posed by genetic interventions, necessitating special considerations in efficacy evaluations, particularly concerning vector design, target specificity, long-term patient monitoring. Ethical such as autonomy, informed consent, privacy also demand careful attention, alongside intricate matter intellectual property rights, which balanced against imperative widespread access these life-saving treatments. Collaborative efforts among bodies, researchers, patent offices, private sector essential tackle effectively, international cooperation being especially crucial given global scope vaccine development. Striking right balance between safeguarding properties promoting public health vital fostering innovation equitable ground-breaking technologies, underscoring significance addressing hurdles fully harness benefits vaccines enhancing healthcare outcomes a scale. STATEMENT OF SIGNIFICANCE: Several biomaterials proposed development nanovaccines, from polymeric micelles, PLGA-/PEI-/PLL-nanoparticles, solid lipid nananoparticles, cationic lipoplexes, liposomes, hybrid materials, dendrimers, carbon nanotubes, hydrogels, quantum dots. Lipid nanoparticles (LNPs) have gained tremendous attention since US Food Drug Administration (FDA) approval Pfizer Moderna's COVID-19 raising awareness vaccines. review provides insights into current strategies issues, clinical trials. By navigating landscapes we can unlock full using range promising towards improving worldwide.
Language: Английский
Citations
38
Molecules, Journal Year: 2024, Volume and Issue: 29(18), P. 4405 - 4405
Published: Sept. 16, 2024
Hepatocellular carcinoma (HCC) ranks among the most prevalent malignant tumors, exhibiting a high incidence rate that presents substantial threat to human health. The use of sorafenib and lenvatinib, commonly employed as single-agent targeted inhibitors, complicates treatment process due absence definitive targeting. Nevertheless, advent nanotechnology has injected new optimism into domain liver cancer therapy. Nanocarriers equipped with active targeting or passive mechanisms have demonstrated capability deliver drugs tumor cells efficiency. This approach not only facilitates precise delivery affected site but also enables drug release, thereby enhancing therapeutic efficacy. As medical technology progresses, there is an increasing call for innovative modalities, including novel chemotherapeutic agents, gene therapy, phototherapy, immunotherapy, combinatorial treatments HCC. These emerging therapies are anticipated yield improved clinical outcomes patients, while minimizing systemic toxicity adverse effects. Consequently, application poised significantly improve HCC treatment. review focused on strategies in this area.
Language: Английский
Citations
4
Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123211 - 123211
Published: Feb. 24, 2025
Language: Английский
Citations
0
Journal of Gastrointestinal Oncology, Journal Year: 2025, Volume and Issue: 16(1), P. 209 - 225
Published: Feb. 1, 2025
Given the limited efficacy of current first-line therapies, there is an urgent need to develop novel treatment strategies improve prognosis patients with unresectable intrahepatic cholangiocarcinoma (uICC). This study aimed evaluate and safety hepatic arterial infusion chemotherapy (HAIC) infusional fluorouracil, leucovorin, oxaliplatin (FOLFOX) regimens (HAIC-FO) plus anti-programmed death-(ligand) 1 immunotherapy [αPD-(L)1] antibody [HAIC+αPD-(L)1] compared systemic (SYS) αPD-(L)1 [SYS+αPD-(L)1] as a for uICC. In this retrospective study, treatment-naive uICC who were treated HAIC+αPD-(L)1 or SYS+αPD-(L)1 included. The clinical characteristics, therapeutic outcomes, adverse events (AEs) in two groups compared. Propensity score matching (PSM) was performed minimize biases between groups. From January 2019 2023, total 182 enrolled; 147 included group 35 group. After PSM, 61 26 groups, respectively. had longer median overall survival (mOS), progression-free (mPFS), PFS (mIPFS) than did (mOS: 14.5 vs. 10.5 months, P=0.02; mPFS: 10.4 6.4 mIPFS: 11.4 6.5 P<0.001). incidence AEs comparable but lower grade 3-4 related anemia, leukopenia, weight loss, fatigue. acceptable toxic effects might outcomes
Language: Английский
Citations
0
Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123330 - 123330
Published: April 1, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 8, 2025
Interventional oncology has become an important part of multidisciplinary cancer treatment following the development interventional radiology. Tumors can release antigens, activate immunity, and cause abscopal effect after therapy. However, activated immune response is limited involves a complex process. New methods to solve problems were developed advent immunotherapy. The combination therapies enhanced antitumor improved patient outcomes with good application prospects. In this review, we have summarized used improve efficacy discussed advancements in combining therapy
Language: Английский
Citations
0
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: April 1, 2025
The creation and development of classical multifunctional nanomaterials are crucial for the advancement nanotherapeutic treatments tumors. Currently, metal–organic frameworks (MOFs) modified with polydopamine (PDA) at forefront nanomedicine research, particularly in tumor diagnostics therapy, owing to their exceptional biocompatibility, expansive specific surface area, multifaceted functionalities, superior photothermal properties, which led significant advancements anti-tumor research. Consequently, a range anti-cancer strategies has been devised by leveraging capabilities MOFs, including intelligent drug delivery systems, photodynamic tailored microenvironment. In order gain deeper insight into role MOFs@PDA cancer diagnosis treatment, it is essential conduct comprehensive review existing research outcomes promptly analyze challenges associated biological applications. This will provide valuable perspectives on potential clinical settings.
Language: Английский
Citations
0
Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 3949 - 3970
Published: May 1, 2025
Extensive exploratory studies have been conducted and promising progress has made in the use of nanomaterials for diagnosis treatment hepatocellular carcinoma (HCC). Here, we aimed to reveal evolution trends this field through bibliometric analysis. English-language publications (1999-2024) HCC were retrieved from Web Science database, eligible articles selected analysis (data extraction, statistical analysis, visualization) using VOSviewer Citespace software. A total 1617 analyzed. The number increased rapidly 2012 peaked 2020. China contributed most publications, United States had citations. Chinese Academy Sciences was influential institution. "International Journal Nanomedicine (DOVE Medical)" published articles, while "Biomaterials (Elsevier)" journal. Jie Tian highest Dan Shao average citation per article. Keyword revealed that nanoparticles targeted drug delivery, therapy imaging research hotspots. Keywords with bursts last three years included photodynamic therapy, sorafenib, tumor microenvironment. Nano-vaccines, nano-antibodies, synergistic therapies emerging therapeutic strategies. seven clinical trials published, but date there no major breakthroughs nanomaterials. Research on shown an overall upward trend, hotspots frontiers focusing nanoparticle-targeted chemotherapies, related microenvironment research.
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 9, 2024
Abstract One of the latest immunotherapeutic strategies involves modulating tumor microenvironment through Toll‐like receptors (TLRs). However, receptor agonists may induce severe systemic inflammation. Bif@PBi‐R, a bacterial nanomotor is developed with tumor‐targeting properties in this study. Bismuth‐based nanoparticles loaded R848 (Bi‐R NPs) are bound to anaerobic bifidobacteria via polydopamine adhesion. Bif@PBi‐R designed deliver bismuth‐based carrying specifically area activate anti‐tumor immunotherapy. Bismuth an excellent nanomaterial for photothermal conversion. Therefore, not only enhances efficacy therapy kill cells directly but also boosts immune response its therapeutic effect. Combining 808 nm laser irradiation significantly promoted dendritic cell (DCs) maturation, leading potent In summary, effectively immunotherapy when combined (PTT).
Language: Английский
Citations
3
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 13(1), P. 117 - 136
Published: Nov. 6, 2024
This article reviews the application of biomaterials in combination with immunotherapy to enhance localized treatment tumors, along current challenges and future development directions this field.
Language: Английский
Citations
0