Synthesis, Structure, Spectral, and Electrochemical Properties of New Visible to NIR Absorbing 3-Pyrrolyl BODIPY Derivatives DOI
Kanhu Charan Behera,

Pinky Chauhan,

Shubham Tiwari

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

This study presents 3-pyrrolyl BODIPY-based Schiff base and benzothiazole derivatives with tunable red-to-NIR properties, highlighting a Re( i ) complex distorted octahedral geometry for its potential in coordination chemistry.

Language: Английский

Sonodynamic Activated Nanoparticles with Glut1 Inhibitor and Cystine-containing Polymer Stimulate Disulfidptosis for Improved Immunotherapy in Bladder Cancer DOI Creative Commons
Ke Wang, Li Li,

Ganghao Liang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123178 - 123178

Published: Feb. 8, 2025

Language: Английский

Citations

1
Ruthenium(II) Polypyridyl Complexes Containing COUBPY Ligands as Potent Photosensitizers for the Efficient Phototherapy of Hypoxic Tumors DOI

Diego Abad-Montero,

Albert Gandioso, Eduardo Izquierdo‐García

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: 147(9), P. 7360 - 7376

Published: Feb. 15, 2025

Hypoxia, a hallmark of many solid tumors, is linked to increased cancer aggressiveness, metastasis, and resistance conventional therapies, leading poor patient outcomes. This challenges the efficiency photodynamic therapy (PDT), which relies on generation cytotoxic reactive oxygen species (ROS) through irradiation photosensitizer (PS), process partially dependent levels. In this work, we introduce novel family potent PSs based ruthenium(II) polypyridyl complexes with 2,2′-bipyridyl ligands derived from COUPY coumarins, termed COUBPYs. Ru-COUBPY exhibit outstanding in vitro cytotoxicity against CT-26 cells when irradiated light within phototherapeutic window, achieving nanomolar potency both normoxic hypoxic conditions while remaining nontoxic dark, impressive phototoxic indices (>30,000). Their ability generate Type I II ROS underpins their exceptional PDT efficiency. The lead compound study, SCV49, shows favorable vivo pharmacokinetic profile, excellent toxicological tolerability, tumor growth inhibition mice bearing subcutaneous tumors at doses as low 3 mg/kg upon deep-red (660 nm). These results allow us propose SCV49 strong candidate for further preclinical development, particularly treating large tumors.

Language: Английский

Citations

1
Biodegradable iridium coordinated nanodrugs potentiate photodynamic therapy and immunotherapy of lung cancer DOI

Jingyao Li,

Huixi Yi,

Yuanyuan Fu

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 680, P. 9 - 24

Published: Oct. 30, 2024

Language: Английский

Citations

4
Ultrasound-responsive nanobubble-mediated sonodynamic therapy sensitizes disulfidptosis in the treatment of liver hepatocellular carcinoma DOI Creative Commons
Yichi Chen, Xin Lin, Jiayue Qiu

et al.

Ultrasonics Sonochemistry, Journal Year: 2025, Volume and Issue: 118, P. 107368 - 107368

Published: April 23, 2025

Disulfidptosis, a newly identified regulated cell death, is linked to tumor progression, particularly in cancers with elevated SLC7A11 expression. This study investigates expression liver hepatocellular carcinoma (LIHC) and evaluates the therapeutic potential of ICG@C3F8-KL nanobubbles (NBs) combined sonodynamic therapy (SDT) for inducing disulfidptosis. Bioinformatics analysis TCGA datasets revealed upregulation LIHC tissues. The synthesized NBs exhibited mean diameter 156.46 nm stable properties, high encapsulation efficiencies 51.32 % ± 0.7 KL 80.15 0.21 ICG. In vitro, NBs, under ultrasound, generated reactive oxygen species (ROS), enhancing cytotoxicity HepG2 cells an IC50 lower than alone. These also inhibited migration colony formation, suggesting disulfidptosis induction via altered glucose uptake NADP+/NADPH ratio, as well F-actin contraction. vivo, accumulated tissues suppressed growth without significant toxicity. Unsupervised clustering disulfidptosis-related genes cohort subtypes distinct prognoses, predictive model based on five key was developed. conclusion, effectively induce disulfidptosis, offering promising strategy treatment, personalized informed by disulfide-associated gene signatures.

Language: Английский

Citations

0
A comparative study of PEO-PBO content on the targeting and anti-glioma activity of annonaceous acetogenins-loaded nanomicelles DOI
Hui Ao, Yao Fu, Xiangtao Wang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 244, P. 114176 - 114176

Published: Aug. 30, 2024

Language: Английский

Citations

1
Breaking the deep-red light absorption barrier of iridium(III)-based photosensitizers. DOI
Gloria Vigueras, Gilles Gasser, José Ruiz

et al.

Dalton Transactions, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Recent advancements in ligand design and fluorophore functionalization enable Ir( iii ) photosensitizers to achieve deep-red/near-infrared absorption, addressing challenges photodynamic therapy for deep-seated tumors.

Language: Английский

Citations

1
Biodegradable Iridium Coordinated Nanodrugs Potentiate Photodynamic Therapy and Immunotherapy of Lung Cancer DOI

Jingyao Li,

Huixi Yi,

Yuanyuan Fu

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Synthesis, Structure, Spectral, and Electrochemical Properties of New Visible to NIR Absorbing 3-Pyrrolyl BODIPY Derivatives DOI
Kanhu Charan Behera,

Pinky Chauhan,

Shubham Tiwari

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

This study presents 3-pyrrolyl BODIPY-based Schiff base and benzothiazole derivatives with tunable red-to-NIR properties, highlighting a Re( i ) complex distorted octahedral geometry for its potential in coordination chemistry.

Language: Английский

Citations

0