Clinical Cosmetic and Investigational Dermatology,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 2417 - 2426
Published: Oct. 1, 2024
Skin
photoaging,
resulting
from
prolonged
exposure
to
ultraviolet
(UV)
radiation,
is
characterized
by
intricate
biological
changes
involving
oxidative
damage
and
structural
alterations.
Despite
an
increasing
demand
for
effective
interventions,
the
current
therapeutic
options
treating
skin
photoaging
are
limited.
We
discovered
through
literature
data
search
on
PubMed
that
recent
research
has
shifted
its
focus
application
of
microneedle
patches
as
innovative
approach
address
this
concern.
Microneedle
patches,
serving
a
novel
transdermal
delivery
system,
exhibit
potential
deliver
bioactive
substances
such
cytokines,
cellular
vesicles,
gene
fragments
even
alive
algae
mitigate
effects
photoaging.
This
review
aims
provide
comprehensive
overview
advancements
in
about
utilizing
treatment
future
directions
leveraging
clinical
agents
rejuvenation.
Ultimately,
we
believe
have
broader
prospect
fields
medical
cosmetology
anti-photoaging.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 248 - 248
Published: Feb. 13, 2025
Obesity
has
become
a
major
public
health
threat,
as
it
can
cause
various
complications
such
diabetes,
cardiovascular
disease,
sleep
apnea,
cancer,
and
osteoarthritis.
The
primary
anti-obesity
therapies
include
dietary
control,
physical
exercise,
surgical
interventions,
drug
therapy;
however,
these
treatments
often
have
poor
therapeutic
efficacy,
significant
side
effects,
unavoidable
weight
rebound.
As
revolutionized
transdermal
delivery
system,
microneedles
(MNs)
been
increasingly
used
to
deliver
therapeutics
subcutaneous
adipose
tissue
or
targeted
absorption
sites,
significantly
enhancing
anti-obese
effects.
Nevertheless,
there
is
still
lack
of
review
comprehensively
summarize
the
latest
progress
MN-mediated
treatment
obesity.
This
provides
an
overview
application
MN
technology
in
obesity,
focusing
on
promote
browning
white
(WAT),
suppress
adipogenesis,
improve
metabolic
function.
In
addition,
this
presents
detailed
examples
integration
with
iontophoresis
(INT)
photothermal
therapy
(PTT)
penetration
into
deeper
dermis
exert
synergistic
Furthermore,
challenges
prospects
for
obesity
are
also
discussed,
which
helps
guide
design
optimization
MNs.
Overall,
insight
development
clinical
translation
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
Obesity
is
a
major
global
health
challenge,
significantly
elevating
the
risk
of
cardiovascular
disease
and
type
II
diabetes.
In
this
study,
we
identified
that
self-assembled
stearic-acid-modified
chitosan
oligosaccharide
(COA)
nanoparticles
can
efficiently
degrade
lipid
droplets
in
adipocytes
via
autolysosomal
pathways.
By
integrating
COA
with
photothermal
therapy
(PTT),
developed
combination
delivered
through
an
effervescent
microneedle
(MN)
patch
for
treating
diet-induced
obesity
mice.
The
MN
demonstrated
superior
skin
penetration
due
to
efficient
separation
needle
tips
from
backing
layer.
Over
four-week
treatment
period,
nanoparticle
indocyanine
green
coloaded
patches
dramatically
reduced
body
weight
white
adipose
tissue
obese
mice
without
affecting
their
food
intake.
Histological
analysis
further
revealed
droplet
size
increased
expression
UCP-1
within
tissues
vivo.
Additionally,
improved
glucose
metabolism
insulin
sensitivity
These
findings
suggest
patch,
when
combined
localized
PTT,
effectively
combat
its
associated
metabolic
complications
mouse
model.
This
approach
presents
promising
alternative
oral
injectable
loss
medications,
offering
efficacy
fewer
side
effects.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 25, 2025
Abstract
The
development
of
soft
mechanocaloric
materials
is
becoming
increasingly
important
due
to
the
growing
demand
for
energy‐efficient
and
environmentally
friendly
thermoregulation
solutions.
Here
effects
in
materials,
which
can
convert
mechanical
energy
into
heat
energy,
discussed,
their
applications
sensing,
therapeutics,
explored.
It
begins
by
introducing
principles
effect
recent
advances
its
study
within
materials’
systems.
Then
personalized
healthcare
sustainable
Finally,
importance
identifying
with
high
coefficients
low
manufacturing
costs
emphasized
broaden
applicability.
Additionally,
a
comprehensive
perspective
on
provided
both
heating
cooling
applications,
emphasizing
transformative
potential
various
fields.
Molecular Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Obesity
is
a
global
metabolic
health
epidemic
characterized
by
excessive
lipid
and
fat
accumulation,
leading
to
severe
conditions
such
as
diabetes,
cancer,
cardiovascular
disease.
Immediate
attention
management
of
obesity-related
risks
are
most
warranted.
The
imbalance
between
absorption,
rate,
environmental
genetic
factors
responsible
for
obesity.
Treatment
typically
involves
lifestyle
modifications,
pharmacotherapy,
surgery.
While
changes
crucial,
effective
treatment
often
necessitates
medication
preferred
adjunct
strategy.
However,
medications
commonly
used,
oral
show
side
effects
due
systemic
exposure
and,
thus,
may
not
effectively
target
the
intended
areas,
drug
loss.
On
other
hand,
transdermal
administration
drugs
with
microneedle
(MN)-based
technologies,
painless
delivery
approach
patient
compliance,
gaining
interest
an
alternative
obesity
treatment,
it
directly
targets
adipose
tissue
via
local
delivery,
minimizing
system
dose
reduction.
This
Review
addresses
pathophysiology
obesity,
current
strategies,
challenges
in
using
conventional
formulations,
importance
use
nano-based
through
MNs
promising
platform
nanoparticle-based
anti-obesity
medications.
potential
combining
stimuli-responsive
non-responsive
adjuvant
therapies
enhance
efficacy
outcomes
explored.
In
addition,
limitations
future
perspectives
related
addressed
highlight
transformative
this
technology
management.
hold
promise
precisely
delivering
while
requiring
lower
dosages
compared
or
injectable
ultimately
improving
quality
life
individuals
struggling
its
associated
comorbidities.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1344 - 1344
Published: Oct. 21, 2024
Drug
delivery
systems
(DDS)
have
improved
therapeutic
agent
administration
by
enhancing
efficacy
and
patient
compliance
while
minimizing
side
effects.
They
enable
targeted
delivery,
controlled
release,
bioavailability.
Transdermal
drug
(TDDS)
offer
non-invasive
medication
evolved
to
include
methods
such
as
chemical
enhancers,
iontophoresis,
microneedles
(MN),
nanocarriers.
MN
technology
provides
innovative
solutions
for
chronic
metabolic
diseases
like
diabetes
obesity
using
various
types.
For
management,
MNs
continuous
glucose
monitoring,
diabetic
wound
healing,
painless
insulin
delivery.
treatment,
provide
sustained
transdermal
of
anti-obesity
drugs
or
nanoparticles
(NPs).
Hybrid
integrating
wearable
sensors
smart
materials
enhance
treatment
effectiveness
management.
Nanotechnology
has
advanced
nano-scaled
liposomes
polymeric
NPs
with
MNs.
In
glucose-responsive
facilitate
At
the
same
time,
lipid
nanocarriers
in
dissolving
extended
release
stability
absorption
disorder
therapies.
DDS
are
advancing
toward
personalized
treatments
enhanced
nanomaterials.
These
approaches
can
outcomes
through
precise
real-time
monitoring.
However,
widespread
implementation
faces
challenges
ensuring
biocompatibility,
improving
technologies,
scaling
production,
obtaining
regulatory
approval.
This
review
will
present
recent
advances
developing
applying
nanomaterial-enhanced
management
also
discussing
challenges,
limitations,
future
perspectives
these
DDS.
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 8, 2024
Abstract
Frequent
nocturia‐induced
nighttime
visits
aggravate
falls
in
seniors,
requiring
synthetic
antidiuretic
drugs
that
risk
the
dangerous
syndrome
of
inappropriate
hormone
secretion
(SIADH),
thus
detection
sodium
ion
and
uric
acid
alterations
during
treatment
is
obligatory
for
drug‐safe
management.
Herein,
we
design
a
convolutional
neural
network
(CNN)‐enhanced
smart
wearable
microneedle
array‐based
colorimetric
(WMNC)
sensor
to
independently
detect
vivo
interstitial
fluid
(ISF)
ions
alterations.
The
WMNC
composed
vacuum
tube‐driven
array
patch
built‐in
sensing
paper,
enabling
an
efficient
ISF
extraction
rapid
assay.
Furthermore,
leveraging
self‐designed
CNNs,
efficiently
eliminates
influence
ambient
light
on
outcomes,
facilitating
accurate
result
classification.
This
study
provides
ISF‐based
rapid,
intuitionistic,
user‐friendly,
point‐of‐care
technique
elderly
suffering
from
nocturia
monitoring
their
health
status
early
warnings
SIADH.
