Antifouling Immunomodulatory Copolymer Architectures That Inhibit the Fibrosis of Implants DOI Open Access
William J. Jeang, Bryan M. Wong, Yichao Zhao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Immune reactions to medical implants often lead encapsulation by fibrotic tissue and impaired device function. This process is thought initiate protein adsorption, which enables immune cells attach mount an inflammatory response. Previously, several antifibrotic materials have been either designed reduce adsorption or discovered via high-throughput screens (HTS) favorably regulate inflammation. The present work introduces antifouling immunomodulatory (AIM) copolymer coatings, combine both strategies effectively enhance implant protection. AIM copolymers synergistically integrate zwitterionic moieties resist fouling, HTS-derived antifibrotics for immunomodulation, silane monomers grafting diverse substrates including elastomers, ceramics, metals. Interestingly, simply combining these into conventional random block architectures yielded no significant advantage over homopolymers. By contrast, unusual polymer chain architecture - a flanked mixed segment showed superior fibrosis resistance in peritoneal subcutaneous sites one month immunocompetent mice. also improved the performance of two different monomers, suggesting that tailoring may broadly complement chemistries provide versatile approach improving longevity.

Language: Английский

Innovative Approaches to Boost Mesenchymal Stem Cells Efficacy in Myocardial Infarction Therapy DOI Creative Commons
Chuanfeng An, Yuan Zhao, Lipeng Guo

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101476 - 101476

Published: Jan. 9, 2025

Stem cell-based therapy has emerged as a promising approach for heart repair, potentially regenerating damaged tissue and improving outcomes patients with disease. However, the efficacy of stem therapies remains limited by several challenges, including poor cell survival, low retention rates, integration, functional outcomes. This article reviews current enhancement strategies to optimize mesenchymal cardiac repair. Key approaches include optimizing delivery methods, enhancing engraftment, promoting functions through genetic molecular modifications, paracrine effects cells, leveraging biomaterials engineering techniques. By focusing on these techniques, paper highlights innovative that can transform into more viable effective treatment option The ongoing research technological advancements continue push boundaries, hoping make mainstream

Language: Английский

Citations

0
Engineering microcapsules with immune modulatory properties: Applications in cancer, inflammation, and autoimmunity DOI

Xin Tan,

Renwang Sheng, Liqin Ge

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161208 - 161208

Published: March 1, 2025

Language: Английский

Citations

0
Clonorchis sinensis-infected hepatocellular carcinoma exhibits distinct tumor microenvironment and molecular features DOI Creative Commons

Junxian Chen,

Caibiao Wei, Wen‐Cheng Huang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 17, 2025

Clonorchis sinensis (Cs)-infected hepatocellular carcinoma (HCC) patients have a poorer prognosis than non-Cs-infected HCCs. However, the molecular mechanisms of Cs-infected HCC remain unclear. To address this, this study aims to uncover tumor microenvironment and features that may contribute these poor outcomes. The research involved bulk RNA sequencing paired adjacent tissue samples from 10 Cs + - patients. Differentially expressed genes were identified, followed by enrichment analyses reveal functional changes. Survival analysis top up- down-regulated in tumors was performed using TCGA database. Additionally, clinical data 1,461 retrospectively analyzed assess impact infection on microvascular invasion metastasis rates. In vitro assays also conducted excretory/secretory products (CsESPs) examine their effect cells HUVECs. We identified 785 up-regulated 675 compared tumors, enriched pathways related extracellular matrix remodeling immunosuppression. revealed are associated with prognosis. Clinical showed increased vitro, CsESPs enhanced migration promoted tube formation human umbilical vein endothelial cells. This provides novel insights into landscape underscores infection's role enhancing migration, angiogenesis. findings understanding parasitic infections cancer progression suggest potential prognostic markers for HCC.

Language: Английский

Citations

0
Idiopathic pulmonary fibrosis microenvironment: Novel mechanisms and research directions DOI Creative Commons
Feng Gao, Lei Pan, Wei Liu

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114653 - 114653

Published: April 14, 2025

Language: Английский

Citations

0
Antifouling Immunomodulatory Copolymer Architectures That Inhibit the Fibrosis of Implants DOI Open Access
William J. Jeang, Bryan M. Wong, Yichao Zhao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Immune reactions to medical implants often lead encapsulation by fibrotic tissue and impaired device function. This process is thought initiate protein adsorption, which enables immune cells attach mount an inflammatory response. Previously, several antifibrotic materials have been either designed reduce adsorption or discovered via high-throughput screens (HTS) favorably regulate inflammation. The present work introduces antifouling immunomodulatory (AIM) copolymer coatings, combine both strategies effectively enhance implant protection. AIM copolymers synergistically integrate zwitterionic moieties resist fouling, HTS-derived antifibrotics for immunomodulation, silane monomers grafting diverse substrates including elastomers, ceramics, metals. Interestingly, simply combining these into conventional random block architectures yielded no significant advantage over homopolymers. By contrast, unusual polymer chain architecture - a flanked mixed segment showed superior fibrosis resistance in peritoneal subcutaneous sites one month immunocompetent mice. also improved the performance of two different monomers, suggesting that tailoring may broadly complement chemistries provide versatile approach improving longevity.

Language: Английский

Citations

1