Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123405 - 123405
Published: May 1, 2025
Language: Английский
Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 44, P. 102568 - 102568
Published: Feb. 9, 2025
Language: Английский
Citations
1
Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)
Published: March 14, 2025
Emerging evidence reveals a complex association between type 2 diabetes (T2D) and coronary heart disease (CHD), which share common risk factors biological pathways. This study aims to identify the shared proteomic signatures of T2D CHD, as well whether proteins predict incident CHD in patients, develop predictive models. Utilizing data from 53,014 UK Biobank participants 2923 plasma proteins, we identified 488 associated with T2D, 125 were also CHD. Among determine nine showing causal associations including PCSK9, NRP1, CD27. Mediation analyses suggest that mediate By integrating these into our model, achieved desirable prediction (AUC = 0.819) for future onset patients. Additionally, druggability evaluation show 32 potential therapeutic agents, established antihypertensives novel compounds, suggesting avenues dual-targeted treatment strategies. Collectively, findings unveil both providing implications screening predicting
Language: Английский
Citations
1
Published: Jan. 1, 2025
Language: Английский
Citations
0
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
Skin wound healing remains challenging due to a lack of ideal dressings suitable for acute and chronic wounds. This study introduced biocompatible hydrogel dressing, synthesized through green chemistry approach, specifically designed meet the dual needs care. The innovative strategy utilized sustainable biomaterials, soy protein, vanillin, construct physical–reversible chemical dual-cross-linked exhibiting high mechanical strength, excellent adhesion, toughness. Schiff base reversible covalent bonds enabled rapid self-healing within 10 s, significantly improving durability. In rat liver hemorrhage model, rapidly sealed wounds, achieving effective hemostasis, indicating great potential Furthermore, vanillin imparted with antimicrobial antioxidant properties, effectively accelerating diabetic healing. safe efficient advanced biobased offers novel perspective treatment holds significant promise clinical applications.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162544 - 162544
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 693, P. 137616 - 137616
Published: April 16, 2025
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142725 - 142725
Published: April 1, 2025
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: April 6, 2025
Inducing rapid angiogenesis by delivering specific biological cues is critical for diabetic wound healing. Nevertheless, the hindered inflammatory microenvironment, and immune cells fail to orchestrate responses Herein, vascular endothelial growth factor (VEGF) plasmids-loaded macrophage exosomes (Exos) were fabricated enfolded in injectable self-healing hydrogels programmed therapy of wounds through sequentially intrinsically modulating microenvironment promoting angiogenesis. The hydrogels, formed via dynamical Schiff base reactions using modified polysaccharides, regulate broad-spectrum antioxidant activity phenotype regulation, restoring tissue redox homeostasis. Furthermore, can stabilize release engineered exosomes. By integration generation VEGF Exos, secretion M2 macrophages, enhanced binding receptor 2 high affinity sulfated chitosan, intrinsic immunomodulatory effectively promote accelerate healing process.
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 25, 2025
Abstract Continuously bacterial infection, undue oxidative stress, and inflammatory responses in the skin tissue microenvironment determine delayed healing outcome of diabetic wounds, which remain a tough clinical challenge need multifaceted therapeutic strategies. In this work, HA‐ADH/HA‐QA‐ALD‐based hydrogel microneedle (HAQA‐MN) with antimicrobial antioxidative activities incorporating kinsenoside (KD) coated macrophage membrane (M‐KD) targeting inflammation relief is developed to improve cutaneous micro‐niche. KD observed trigger trimethylamine N‐oxide‐irritated proinflammatory macrophages repolarization from M1 state anti‐inflammatory M2 phenotype, underlying mechanism due drug‐induced IRE1α/XBP1/HIF‐1α pathway suppression, accompanied by diminution glycolysis enhancement phosphorylation, resulting cascade inhibition signaling enhancement. The hydrazone cross‐linked HAQA‐MN possesses favorable biocompatibility, self‐healing, controlled release M‐KD excellent mechanical properties. Moreover, MN patch remarkedly restrains survival E. coli S. aureus eliminates hydrogen peroxide preserve cellular viability. Notably, M‐KD@HAQA‐MN array effectively ameliorates stress facilitate angiogenesis collagen deposition, thereby accelerating regeneration mice full‐thickness defect model. Collectively, study highlights multifunctional platform as promising candidate application for treatment wounds.
Language: Английский
Citations
0
Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123405 - 123405
Published: May 1, 2025
Language: Английский
Citations
0