Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118197 - 118197
Published: April 1, 2025
Language: Английский
Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)
Published: Jan. 10, 2025
Abstract Cancer vaccines, crucial in the immunotherapeutic landscape, are bifurcated into preventive and therapeutic types, both integral to combating oncogenesis. Preventive cancer like those against HPV HBV, reduce incidence of virus-associated cancers, while vaccines aim activate dendritic cells cytotoxic T lymphocytes for durable anti-tumor immunity. Recent advancements vaccine platforms, such as synthetic peptides, mRNA, DNA, cellular, nano-vaccines, have enhanced antigen presentation immune activation. Despite US Food Drug Administration approval several full potential remains unrealized due challenges selection, tumor-mediated immunosuppression, optimization delivery systems. This review provides a comprehensive analysis aims implications vaccine, innovative discovery neoantigens enhancing specificity, latest strides platforms. It also critically evaluates role adjuvants immunogenicity mitigating immunosuppressive tumor microenvironment. The further examines synergistic combining with other therapies, chemotherapy, radiotherapy, checkpoint inhibitors, improve outcomes. Overcoming barriers effective identification, microenvironments, adverse effects is critical advancing development. By addressing these challenges, can offer significant improvements patient outcomes broaden scope personalized immunotherapy.
Language: Английский
Citations
2
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: March 21, 2025
Immunotherapy has emerged as a preeminent force in the domain of cancer therapeutics and achieved remarkable breakthroughs. Nevertheless, high resistance become most substantial impediment restricting its clinical efficacy. Beta-2 microglobulin (B2M), light chain major histocompatibility complex (MHC) class I, plays an indispensable part by presenting tumor antigens to cytotoxic T lymphocytes (CTLs) for exerting anti-tumor effects. Accumulating evidence indicates that B2M mutation/defect is one key mechanisms underlying immunotherapy resistance. Therefore, elucidating role played devising effective strategies battle against are pressing issues. This review will systematically expound upon them, aiming provide insight into potential promising target anticancer immune response.
Language: Английский
Citations
1
Exploration of Targeted Anti-tumor Therapy, Journal Year: 2025, Volume and Issue: 6
Published: April 10, 2025
Immunotherapy has gathered significant attention and is now a widely used cancer treatment that uses the body's immune system to fight cancer. Despite initial successes, its broader clinical application hindered by limitations such as heterogeneity in patient response challenges associated with tumor microenvironment. Recent advancements nanotechnology have offered innovative solutions these barriers, providing enhancements immunotherapy. Nanotechnology-based approaches exhibit multifaceted mechanisms, including effective anti-tumor responses during tumorigenesis overcoming suppression mechanisms improve defense capacity. Nanomedicines, nanoparticle-based vaccines, liposomes, modulators, gene delivery systems, demonstrated ability activate responses, modulate microenvironments, target specific cells. Success metrics preclinical early studies, improved survival rates, enhanced regression, elevated activation indices, highlight promise of technologies. achievements, several remain, scaling up manufacturing, addressing off-target effects, navigating regulatory complexities. The review emphasizes need for interdisciplinary address ensuring adoption. It also provides insights into approaches, advancements, transformative potential nano-immunotherapy promising results checkpoint inhibitor delivery, nanoparticle-mediated photothermal therapy, immunomodulation well inhibition nanoparticles vaccines.
Language: Английский
Citations
0
Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118197 - 118197
Published: April 1, 2025
Language: Английский
Citations
0