Engineering a wirelessly self-powered neural scaffold based on primary battery principle to accelerate nerve cell differentiation

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114521 - 114521

Published: Jan. 14, 2025

Language: Английский

Nanohybrid Hydrogel with Dual Functions: Controlled Low‐Temperature Photothermal Antibacterial Activity and Promoted Regeneration for Treating MRSA‐Infected Bone Defects

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Methicillin-resistant Staphylococcus aureus (MRSA)-related bone defects pose significant clinical challenges due to treatment failures. Here, an injectable nanohybrid hydrogel (FND-ZHD) is developed that combines controlled low-temperature photothermal antibacterial therapy with enhanced regeneration. The uses Pluronic F-127 as the matrix, incorporating polydopamine-coated nano-hydroxyapatite and zinc oxide nanoparticles encapsulated polydopamine hyaluronic acid, forming a sophisticated nanostructured composite. Under near-infrared (NIR) irradiation, FND-ZHD exhibits efficient properties, enabling precise eliminate MRSA infections. process generates reactive oxygen species (ROS), contributing potent activity, while design allows self-elimination of excess ROS minimize cytotoxicity. Simultaneously, enhances regeneration by upregulating heat shock protein 70 (HSP70), promoting osteogenic differentiation accelerating repair. In vitro in vivo experiments demonstrate not only possesses strong efficacy against but also significantly improves healing infected defect models. This dual-function strategy leverages synergistic effects nanomaterials at nano- microscale, achieving simultaneous action work highlights potential nanotechnology-based multifunctional biomaterials addressing complex medical problems, paving way for advanced therapies orthopedic regenerative medicine.

Language: Английский

Bioresorbable High-Strength HA/PLLA Composites for Internal Fracture Fixation

Molecules, Journal Year: 2025, Volume and Issue: 30(9), P. 1889 - 1889

Published: April 23, 2025

In modern surgery, the internal fixation plates fabricated from hydroxyapatite/poly(L-lactide) (HA/PLLA) composites encounter clinical limitations in fracture treatment due to their inadequate mechanical properties. this work, pressure-induced flow (PIF) technique is employed address limitation. Under optimal processing conditions (140 °C and 250 MPa), HA/PLLA exhibit an impressive flexural strength of 199.2 MPa, which comparable that human cortical bone, strongest bone tissue body. The tensile notched Izod impact are close 84.2 MPa 16.7 kJ/m2, respectively. Meanwhile, develop multi-level stacked crystal layers during PIF processing, accompanied by increases crystallinity (53.1%), orientation (81.6%) glass transition temperature (78.8 °C). After 2 months vitro degradation, processed still maintain considerable (135.3 MPa). excellent properties expand potential as plate.

Language: Английский