Inhibiting synovial inflammation and promoting cartilage repair in rheumatoid arthritis using a matrix metalloproteinase-binding hydrogel DOI Creative Commons

Zhanpeng Xue,

Nan Li, Kui Du

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101792 - 101792

Published: April 23, 2025

Language: Английский

Theranostic hydrogels: Construction strategies and applications DOI

Xiaolong Li,

Ruiyang Li, Fuxiao Wang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159545 - 159545

Published: Jan. 13, 2025

Language: Английский

Citations

3
Nanoparticle-Reinforced Hydrogel with a Well-Defined Pore Structure for Sustainable Drug Release and Effective Wound Healing DOI Creative Commons
Z. Zhang, Siyu Yang,

Feixue Mi

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Impaired chronic wounds are a common complication of diabetes. Inhibited angiogenesis and dysfunctional inflammation render diabetic wound healing critical challenge. Herein, sustainable therapeutic composite hydrogel is presented for healing, consisting cocktail formulation anti-inflammatory local anesthetic nanoparticles incorporated into hydrogel. The surface-modified drug loaded the biocompatible hydrogels cross-linked with gel precursor to enhance structure. delivery system achieves more than 90% release, total therapy duration tunable from 4 72 h. Through long-lasting analgesic effects hydrogel, swiftly transitioned proliferation phase, augmenting survival migration keratinocytes facilitating neovascularization collagen alignment in wounds. These significantly improve rate skin regeneration process, achieving that 17 times untreated This study demonstrates platform promising rapid

Language: Английский

Citations

0
Multidimensional exploration of hydrogels as biological scaffolds for spinal cord regeneration: mechanisms and future perspectives DOI Creative Commons
Cheng Han, Jiao Jiao, Chan Gong

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 23, 2025

Spinal cord injury (SCI) is a severe condition that frequently leads to permanent disabilities and neurological dysfunction. Its progression driven by multifaceted pathophysiology, encompassing direct trauma, secondary cascades, intricate cellular molecular responses. While current therapies focus on alleviating symptoms restoring functionality, achieving effective neural regeneration in the spinal continues be significant challenge. Hydrogels, recognized for their exceptional biocompatibility, conductivity, injectability, have shown great potential as advanced scaffolds support neuronal axonal regeneration. Recently, these materials attracted interest field of SCI rehabilitation research. This review concludes recent progress hydrogel-based strategies rehabilitation, emphasizing distinct properties, underlying mechanisms, integration with bioactive molecules, stem cells, complementary biomaterials. Hydrogels foster providing tailored microenvironment, while features such self-repair, electrical controlled drug release significantly enhance therapeutic experimental models. explores hydrogel technologies applications, underscoring address challenges treatment paving way future clinical implementation.

Language: Английский

Citations

0
Inhibiting synovial inflammation and promoting cartilage repair in rheumatoid arthritis using a matrix metalloproteinase-binding hydrogel DOI Creative Commons

Zhanpeng Xue,

Nan Li, Kui Du

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101792 - 101792

Published: April 23, 2025

Language: Английский

Citations

0