Advances in Research on M1/M2 Macrophage Polarization in the Pathogenesis and Treatment of Osteoarthritis

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e42881 - e42881

Published: Feb. 1, 2025

Language: Английский

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Anti-Inflammatory Potential of Quercetin: From Chemistry and Mechanistic Insight to Nanoformulations

Current Research in Pharmacology and Drug Discovery, Journal Year: 2025, Volume and Issue: unknown, P. 100217 - 100217

Published: March 1, 2025

Language: Английский

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Polymeric Nanosystems: A Breakthrough Approach to Treating Inflammation and Inflammation Related Diseases

Biopolymers, Journal Year: 2025, Volume and Issue: 116(3)

Published: March 19, 2025

ABSTRACT Inflammation processes can cause mild to severe damage in the human body and lead a large number of inflammation‐related diseases (IRD) such as cancer, neural, vascular, pulmonary diseases. Limitations anti‐inflammatory drugs (AID) application are reflected high therapeutic doses, toxicity, low bioavailability solubility, side effects, etc. Polymeric nanosystems (PS) have been recognized safe effective technology that is able overcome these limitations by AID encapsulation answer specific demands IRD treatment. PS attracting great attention due their versatility, biocompatibility, fine‐tuned properties, functionality, ability for precise delivery targeted sites body. This article offers an overview three classes polymeric nanosystems: a) dendrimers, b) micelles nanoparticles, c) filomicelles, well preparation, In future, formulations clinical practice will certainly increase.

Language: Английский

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Intelligent Nanomaterials Design for Osteoarthritis Managements

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Osteoarthritis (OA) is the most prevalent degenerative joint disorder, characterized by progressive degradation, pain, and diminished mobility, all of which collectively impair patients' quality life escalate healthcare expenditures. Current treatment options are often inadequate due to limited efficacy, adverse side effects, temporary symptom relief, underscoring urgent need for more effective therapeutic strategies. Recent advancements in nanomaterials nanomedicines offer promising solutions improving drug bioavailability, reducing effects providing targeted benefits. This review critically examines pathogenesis OA, highlights limitations existing treatments, explores latest innovations intelligent design OA therapy, with an emphasis on their engineered properties, mechanisms, translational potential clinical application. By compiling recent findings, this work aims inspire further exploration innovation nanomedicine, ultimately advancing development personalized therapies.

Language: Английский

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Multifunctional piezoelectric hydrogels under ultrasound stimulation boost chondrogenesis by recruiting autologous stem cells and activating the Ca2+/CaM/CaN signaling pathway

Bioactive Materials, Journal Year: 2025, Volume and Issue: 50, P. 344 - 363

Published: April 18, 2025

Language: Английский

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Advances in Nanoparticles in Targeted Drug Delivery- A Review

Results in Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 100529 - 100529

Published: April 1, 2025

Language: Английский

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Macrophage polarization in cancer and beyond: from inflammatory signaling pathways to potential therapeutic strategies

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217772 - 217772

Published: May 1, 2025

Language: Английский

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