Ultrasmall platinum single-atom enzyme alleviates oxidative stress and macrophage polarization induced by acute kidney ischemia–reperfusion injury through inhibition of cell death storm DOI Creative Commons

Keng Ye,

Kevin Lin, Chengkun Wu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 27, 2025

Acute kidney injury (AKI), characterized by a rapid decline in renal function, is associated with impaired mitochondrial function and excessive reactive oxygen species (ROS). Therefore, the exploration of ROS scavengers provides promising new opportunities for prevention treatment AKI mitigating oxidative stress. Here, we construct an ultrasmall platinum single-atom enzyme (Pt/SAE) multiple antioxidant activities to protect against acute ischemia-reperfusion (I/R) injury. Pt/SAE not only mimics superoxide dismutase catalase convert anion into water oxygen, but also exhibits impressive hydroxyl radical scavenging capacity, thereby reducing pro-inflammatory macrophage levels preventing inflammation. Furthermore, reduces accumulation Z-form DNA, which excessively accumulates following I/R damage, thus decreasing its interaction Z-DNA binding protein 1, consequently progression PANoptosis Additionally, downregulation induced suppresses lipid peroxidation, return ferroptosis I/R. Both vitro vivo experiments confirm that effectively mitigates inflammatory cell infiltration promotes shift polarization from M1-like M2-like subtype. This study information development novel SAEs as viable method AKI.

Language: Английский

Macrophage membrane-mimicking nanoparticles for scavenging reactive oxygen species and modulating immune cells in acute kidney injury treatment DOI
Chenghao Wu, Dongsheng Shen, Zhixiang Bian

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161135 - 161135

Published: Feb. 1, 2025

Language: Английский

Citations

0
Multifunctional nanozyme-hydrogel system in bacterial-infected wounds DOI

Yuyu Cui,

Qiang Niu,

Zhiyuan Hu

et al.

Published: April 1, 2025

Language: Английский

Citations

0
Ultrasmall platinum single-atom enzyme alleviates oxidative stress and macrophage polarization induced by acute kidney ischemia–reperfusion injury through inhibition of cell death storm DOI Creative Commons

Keng Ye,

Kevin Lin, Chengkun Wu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 27, 2025

Acute kidney injury (AKI), characterized by a rapid decline in renal function, is associated with impaired mitochondrial function and excessive reactive oxygen species (ROS). Therefore, the exploration of ROS scavengers provides promising new opportunities for prevention treatment AKI mitigating oxidative stress. Here, we construct an ultrasmall platinum single-atom enzyme (Pt/SAE) multiple antioxidant activities to protect against acute ischemia-reperfusion (I/R) injury. Pt/SAE not only mimics superoxide dismutase catalase convert anion into water oxygen, but also exhibits impressive hydroxyl radical scavenging capacity, thereby reducing pro-inflammatory macrophage levels preventing inflammation. Furthermore, reduces accumulation Z-form DNA, which excessively accumulates following I/R damage, thus decreasing its interaction Z-DNA binding protein 1, consequently progression PANoptosis Additionally, downregulation induced suppresses lipid peroxidation, return ferroptosis I/R. Both vitro vivo experiments confirm that effectively mitigates inflammatory cell infiltration promotes shift polarization from M1-like M2-like subtype. This study information development novel SAEs as viable method AKI.

Language: Английский

Citations

0